|Table of Contents|

The clinical value of serum Tracp5b as a marker in diagnosing bone metastases and evaluating the therapeutic efficacy of bisphosphonate in breast cancer patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 05
Page:
715-718
Research Field:
Publishing date:

Info

Title:
The clinical value of serum Tracp5b as a marker in diagnosing bone metastases and evaluating the therapeutic efficacy of bisphosphonate in breast cancer patients
Author(s):
Chen Longzhou1Tang Jing2Liu Juan1Wang Yali1Li Qingguo1
1.Department of Breast,Maternity and Child Health Care Hospital of Huai'an,Jiangsu Huai'an 223001,China;2.Department of Surgery,The Huai'an Hospital Affiliated to Nanjing Medical University,Jiangsu Huai'an 223300,China.
Keywords:
breast cancerTracp5bbone metastasesbisphosphonate
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.05.011
Abstract:
Objective:To discuss the clinical value of serum tartrate-resistant acid phosphatase 5b(Tracp5b) as a marker in diagnosing bone metastases and evaluating the therapeutic efficacy in breast cancer patients.Methods:The serum levels of Tracp5b were determined by enzyme-linked immumosorbent assay(ELISA) in 30 breast cancer patients without bone metastases and 22 breast cancer patients with bone metastases.The 22 cases with bone metastases were detected again after chemical treatment or endocrine therpy while adding 4 months treatment of bisphosphonate.Results:The serum levels of Tracp5b in breast cancer patients with bone metastases were significantly higher than patients without bone metastases (P<0.05).The serum levels of Tracp5b in breast cancer patients with bone metastases decreased significantly after four months treatment (P<0.05).Conclusion:Tracp5b is a useful marker to diagnose bone metastases in breast cancer patients and evaluate the therapeutic efficacy of bisphosphonate.

References:

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Last Update: 2017-01-26