|Table of Contents|

Clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 04
Page:
547-550
Research Field:
Publishing date:

Info

Title:
Clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck
Author(s):
Wang JingLi Zhendong
Department of Head and Neck Surgery,Liaoning Cancer Hospital,Liaoning Shenyang 110042,China.
Keywords:
head and neck cancermucosal melanomaimmunohistochemistryPD-L1
PACS:
R739.91
DOI:
10.3969/j.issn.1672-4992.2017.04.011
Abstract:
Objective:To identify the PD-L1 expression pattern in primary mucosal malignant melanoma,to investigate clinicopathological and outcome associations.Methods:We assessed PD-L1 expression using immunohistochemical staining in 45 tumor samples from patients with primary mucosal melanoma and correlated expression status with clinicopathological and outcome data.Results:All patients had undergone surgery combined with interferon therapy.The probability of 5-year overall survival was 44.4%.The mean overall survival was 51 months and the mean recurrence-free survival was 23 months.Immunohistochemical staining showed PD-L1 expression was in 57.8%(26/45) of mucosal melanoma.In contrast,prominent PD-L1 staining was detected in 6.7%(3/45)of tissue sections from a control group of cutaneous melanoma (P=0.003 7).PD-L1 expression in mucosal melanoma was not correlated with age (P=0.09),gender (P=0.16),localization of the tumor (P=0.08).Interestingly,patients with PD-L1-positive mucosal melanoma had a significantly longer recurrence-free survival (P=0.027).Conclusion:High expression of PD-L1 is associated with poor prognosis as well as clinical progression in primary mucosal malignant melanoma.

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Last Update: 2016-12-29