|Table of Contents|

Progression mechanism and targeted therapy of bone metastases about advanced breast cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
314-318
Research Field:
Publishing date:

Info

Title:
Progression mechanism and targeted therapy of bone metastases about advanced breast cancer
Author(s):
Lu Guangping1Yin Yongmei2Zhou Xuefeng1Pan Jiqun1Chen Jin1
1.Department of Oncology,Dongtai Affiliated Hospital of Nantong University,Jiangsu Dongtai 224200,China;2.Department of Oncology,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Nanjing 210029,China.
Keywords:
breast cancerbone metastasismechanismmicroenvironmentbisphosphonatesdenosumab
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.02.042
Abstract:
Bone metastasis are common symptoms of advanced breast cancer,breast cancer cells via local infiltration,invading into lymphatic and/or blood vessels,travelling in the circulation to the bone,extravasation from lymphatic and/or blood vessels,settling and proliferating in the bone and then caused osteolytic bone lesions.The initiation and development of bone metastasis with breast cancer depends on the interaction between breast cancer cells and the bone microenvironment,finally formed bone structural damage and dysfunction.This article describes the mechanism of bone metastasis of breast cancer at the molecular level,and summaries the clinical application of targeted drugs for the bone metastasis.

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Memo

Memo:
盐城市医学重点人才基金项目(编号:035);盐城市医学科技发展计划基金项目(编号:YK2014084)
Last Update: 2016-12-01