|Table of Contents|

Correlations between patterns of failure of small cell lung cancer and radiotherapy fraction

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
216-219
Research Field:
Publishing date:

Info

Title:
Correlations between patterns of failure of small cell lung cancer and radiotherapy fraction
Author(s):
Wang Weili; Zhong Wen; Liu Dawei; Zhang Guoyun; Zhou Chunyu; Guo Genyan; Liu Xiaolan
Department of Radiation Oncology,the Fourth Affiliated Hospital,China Medical University,Liaoning Shenyang 110032,China.
Keywords:
small cell lung cancer; radiotherapy fraction; patterns of failure; radiotherapy toxicity
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2017.02.014
Abstract:
Objective:To explore the differences of patterns of failure (PoF) between conventional fraction (CF) thoracic radiotherapy (TRT) and accelerated hyper-fraction TRT (HF) in limited-stage small cell lung cancer (SCLC) patients.Methods:We retrospectively reviewed electronic database of SCLC in limited-stage patients treated in our cancer center from October 2006 to December 2012.Clinical data was recorded including clinical features,TRT regimens,PoF,radiation toxicities.The endpoints of this study were the rates of local/regional (LR) recurrences and distant metastases (DM).Results:The differences of first failure patterns and/or overall failure patterns between two regimen groups were not statistically significant (P＞0.05).There were more grade II-III thoracic toxicities in hyper-fraction group.Conclusion:Accelerated hyper-fraction TRT may be not superior to conventional TRT while increasing thoracic toxicity.

References:

［1］Pignon JP,Arriagada R,Ihde DC,et al.A meta-analysis of thoracic radiotherapy for small-cell lung cancer［J］.N Engl J Med,1992,327(23):1618-1624.
［2］Warde P,Payne D.Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis［J］.J Clin Oncol,1992,10(6):890-895.
［3］Videtic GM.The role of radiotherapy in small cell lung cancer:a revisit［J］.Curr Oncol Rep,2015,17(8):458.
［4］Takada M,Fukuoka M,Kawahara M,et al.Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer:results of the Japan Clinical Oncology Group Study 9104［J］.J Clin Oncol,2002,20(14):3054-3060.
［5］Turrisi AT,Kim K,Blum R,et al.Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide［J］.N Engl J Med,1999,340(4):265-271.
［6］Okamoto K,Okamoto I,Takeda M,et al.A phase I study of split-dose cisplatin and etoposide with concurrent accelerated hyperfractionated thoracic radiotherapy in elderly patients with limited-disease small cell lung cancer［J］.Jpn J Clin Oncol,2014,44(8):743-748.
［7］Pijls-Johannesma M,De Ruysscher D,Vansteenkiste J,et al.Timing of chest radiotherapy in patients with limited stage small cell lung cancer:a systematic review and meta-analysis of randomised controlled trials［J］.Cancer Treat Rev,2007,33(5):461-473.
［8］National Comprehensive Cancer Network.Small cell lung cancer［J］.Cancer,2014,3:51.
［9］De Ruysscher D,Pijls-Johannesma M,Bentzen SM,et al.Time between the first day of chemotherapy and the last day of chest radiation is the most important predictor of survival in limited-disease small-cell lung cancer［J］.J Clin Oncol,2006,24(7):1057-1063.
［10］Kong FM,Lally BE,Chang JY,et al.ACR Appropriateness criteria(R) radiation therapy for small-cell lung cancer［J］.Am J Clin Oncol,2013,36(2):206-213.
［11］Wang Weili,Liu Dawei,Guo Genyan，et al.Correlations between prognosis of small cell lung cancer and radiotherapy fraction［J］.Chin Lab Diagnosis,2013,17(4):680-682.［王伟力，刘大伟，郭根燕,等.胸部放疗分割与小细胞肺癌预后的关联性研究［J］.中国实验诊断学,2013,17(4):680-682.］
［12］Janne PA,Freidlin B,Saxman S,et al.Twenty-five years of clinical research for patients with limited-stage small cell lung carcinoma in North America［J］.Cancer,2002,95(7):1528-1538.
［13］Conver T.Concurrent once-daily versus twice-daily radio therapy:a 2-arm randomised controlled trial of concurrent chemo-radiotherapy comparing twice-daily and once-daily radiotherapy schedules in patients with limited stage small cell lung cancer (SCLC) and good performance status［J］.Cancer,2008,17:23.

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Last Update: 2016-12-01