|Table of Contents|

CUEDC2 promotes breast cancer progression through activation of PI3K/Akt signaling pathway

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 02
Page:
183-185
Research Field:
Publishing date:

Info

Title:
CUEDC2 promotes breast cancer progression through activation of PI3K/Akt signaling pathway
Author(s):
Li Yanshu; Gao Yunling; Zhang Hongyan; Tang Li'na; Liu Furong; Li Feng
Department of Cell Biology,Key Laboratory of Cell Biology,Ministry of Public Health and Key Laboratory of Medical Cell Biology,Ministry of Education,College of Basic Medical Science,China Medical University,Liaoning Shenyang 110122,China.
Keywords:
breast cancer; CUE domain-containing 2; cell growth
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.02.005
Abstract:
Objective:To evaluate the biological role of CUEDC2 in human breast cancer cells.Methods:Human breast cancer cell line MCF-7 were transient transfected with Myc-CUEDC2 constructs,and whole-cell lysates were extracted with the level of phosphorylated Akt (p-Akt) and the total Akt proteins.CCK-8 assay was used for detecting the role of CUEDC2 in breast cancer cell line progression.Results:CUEDC2 induced an increase in the level of phosphorylated Akt (p-Akt) and increased the growth of breast cancer cells.Conclusion:Our results suggest that increased expression of CUEDC2 contributes to tumor growth by activation of the PI3K/Akt pathway in breast cancer cell lines,which may be one of the mechanisms that attribute to promote the growth of cancer cells．

References:

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Memo

Memo:
国家自然科学基金资助项目（编号：31371424）
Last Update: 1900-01-01