|Table of Contents|

The expression and significance of Gab1 and PD-L1 in cholangiocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 01
Page:
68-72
Research Field:
Publishing date:

Info

Title:
The expression and significance of Gab1 and PD-L1 in cholangiocarcinoma
Author(s):
Liu Lei1Zhao Xihe2Tian Zhong1
1.General Surgery Department;2.Oncology Department,Shengjing Hospital of China Medical University,Liaoning Shenyang 110022,China.
Keywords:
cholangiocarcinomaGab1PD-L1immunohistochemistry
PACS:
R735.8+5
DOI:
10.3969/j.issn.1672-4992.2017.01.019
Abstract:
Objective:To detect Gab1 and PD-L1 expression in cholangiocarcinoma tissues,adjacent normal tissue and chronic cholangitis,bile duct tissue samples by immunohistochemical methods.Methods:We chose 70 cholangiocarcinoma patients who were confirmed by pathological methods.The paracarcinoma specimens were collected from 30 cases without malignant cells by pathological methods and normal bile duct tissues in 30 cases.The expressions of PD-L1 and Gab1 were detected using immunohistochemistry assay.Results:The positive stainings were those tan and brown grains on cell membranes.It was positively expressed in cholangiocarcinoma tissues and paracarcinoma tissues,while negatively expressed in normal bile duct tissues.The average OD of Gab1 was 0.165 7±0.025 1,in paracarcinoma tissues the OD value was 0.145 3±0.017 7,in normal tissues it was 0.102 1±0.011 5.It represented conspicuous significant difference between the cholangiocarcinoma group and the other two (P<0.05).The PD-L1's average OD value was 0.221 1±0.027 9,in paraneoplastic group was 0.197 1±0.037 2,in normal bile duct tissues 0.175 4±0.014 6.PD-L1 was highly expressed in cholangiocarcinoma group (P<0.05).The expression of Gab1 was positively correlated with the expression of PD-L1 in cholangiocarcinoma (r=0.301 1,P<0.05).Conclusion:Gab1 and PD-L1 were significantly highly expressed in cholangiocarcinoma rather than in adjacent tissues and normal bile duct tissues.Both of them were related to the cholangiocarcinoma's oncogenesis and development.Gab1 content and PD-L1 expressions were positively correlated.

References:

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辽宁省科学技术计划项目(编号:2013408001)
Last Update: 2016-12-01