|Table of Contents|

Research on expression of miRNA-145 in carcinoma of gastric cardia

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

2016 06
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Research on expression of miRNA-145 in carcinoma of gastric cardia
Zhao YiqiJiao FengMin BoQiu LiangZhao Yaping
The 82nd Hospital of the People's Liberation Army,Jiangsu Huai'an 223001,China.
carcinoma of gastric cardiamiRNA-145occurrencemigration
Objective:To investigate miRNA-145 expression characteristics of carcinoma of gastric cardia.Methods:The expression patterns of miRNA-145 in patients with carcinoma of gastric cardia were assessed through microarray assay and qRT-PCR.Results:Compared with the paired normal tumor-adjacent tissue,the expression of miRNA-145 in carcinoma of gastric cardia was significantly down regulated (P<0.05).The expressions of miRNA-145 in lymph node metastasis group were significantly lower than negative group (P<0.05).Conclusion:The down regulation of miRNA-145 might be related to the occurrence and migration of human carcinoma of gastric cardia.


[1] Kim JH,Parkss,Kim J,et al.Surgical outcomes for gastric cancer in the upper third of the stomach[J].World J Surg,2006,30(10):1870-1876.
[2]Jia Yongsheng,Zhang Wenjian,Lou Jinning.The role of miRnas in cancer 145 [J].J Med Res J,2011,40(5):147-149.[贾勇圣,张文健,娄晋宁.microRNA 145在肿瘤中的作用[J].医学研究杂志,2011,40(5):147-149.]
[3]Michael MZ,Smoc,Van Holst Pellekaan NG,et al.Reduced accumulation of specific microRNAs in colorectal neoplasia[J].Mol Cancer Res,2003,1(12):882-891.
[4]Takagi T,Iio A,Nakagawa Y,et al.Decreased expression of MicroRNA-143 and145 in human gastric cancers[J].Oncology,2009,77(1):12-21.
[5]Chen X,Guo X,Zhang H,et al.Role of miR-143 targeting KRAS in colorectal tumor genesis[J].Oncogene,2009,28(10):385-392.
[6]Borralho PM,Simoes AE,Ggmes SE,et al.miR-143 over expression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation[J].PLoS One,2011,6(8):783-787.
[7]Akao Y,Nakagawa Y,Naoe T.MicroRNAs 143 and145 are possible common oneo-microRNAs in human cancers[J].Oncol Rep,2006,16(4):845-850.
[8] Kano M,Seki N,Kikkawa N,et al.miR-145,miR-133aand miR-133b:Tumor suppressive miRNAs target FSCNl in esophageal squamous cell carcinoma[J].Int J Cancer,2010,127(12):2804-2814.
[9]Bandres E,Cubedo E,Agirre X,et al.Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and tumoral tissues[J].Mol Cancer,2006,5(9):23-29.
[10]Zhang J,Guo H,Zhang H,et al.Putative tumor suppressor miR一145 inhibits colon cancer cell growth by targeting oncogene friend leukcmia virus integration gene[J].Cancer,2011,117(1):86-95.
[11]Zhang J,Guo H,Qian G,et al.miR-145,a new regulator of the DNA fragmentation factor-45(DFF-45)-mediated apoptotic network[J].Mol Cancer,2010,9(2):11-16.
[12]Xu Q,Liu LZ,Qian X,et al.miR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis[J].Nucleic Acids Res,2012,40(2):761-774.
[13]Nicoloso MS,Spizzo R,Shimizu M.MicroRNAs- the misesteeming wheel of tumour metastases[J].Nat Rev Cancer,2009,9(4):293-302.
[14]Gotte M,Mohr C,Kooc Y,et al.miR-145-dependenlla gating of junctional adhesion molecule A and modulation of fascin expression are associate(1 with reduced breast cancer cell motility and intuitiveness[J].Oncogene,2010,29(50):6569-6580.
[15]Xu N,Anthropologists T,Pan G,et al.MicroRNA-145 regulates 0CT4,S0x2 and KLF4 and represses plenipotentiary in human embryonic stem cells[J].Cell,2009,137(4):647-658.
[16]Debauchery F,Anthropologist B.Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype[J].Nat Med,2010,16(1):49-58.


Last Update: 2016-01-29