|Table of Contents|

TLR3 and B19 in the pathogenesis of Hashimoto' s thyroiditis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2012 06
Page:
1095-1097
Research Field:
Publishing date:

Info

Title:
TLR3 and B19 in the pathogenesis of Hashimoto' s thyroiditis
Author(s):
ZHANG Weichen; WANG Lu; FAN Linni; ZHU Jin; LI Peifeng; LIU Yixiong; ZHANG Yuehua; HUANG Gaosheng
Departmant of Pathology,Xijing Hospital,The Fourth Military Medical University,Shaanxi Xi'an 710032,China.
Keywords:
Hashimoto's thyroiditis;  Toll-like receptor 3;  parvovirus B19
PACS:
R730.2;R736.1
DOI:
10.3969/j.issn.1672-4992.2012.06.01
Abstract:
Objective：To explore the expression of TLR3 and B19 in Hashimoto's thyroiditis (HT), in order to further clearly define the pathogenesis of HT.Methods：The immunohistochemical staining with streptavidin-peroxidase (SP) and immunoenzymatic double staining procedure were conducted to detect the expression and location of TLR3 and B19 in 33 tissue specimens from patients with HT.HZResults:Both TLR3 and B19 were distributed in thyroid follicular epithelial cells which were close to lymphoid follicles from HT patients and majority of their expression can be detected in the same location. We found that 18 samples of TLR3 positive IHC signals were from cytoplasm and 15 most positive IHC signals of TLR3 were from nuclei in HT specimens, meanwhile, 18 cases of B19 positive IHC signals were from cytoplasm, 11 B19 positive IHC signals were from nuclei and 4 cases were negative. Statistical analysis showed that the expression of TLR3 and B19 was positively correlated to each other (r=0.565,P=0.001). Conclusion: The co-expression of TLR3 and B19 can be detected in thyroid follicular cells from HT specimens and indicated that TLR3 can recognize B19dsRNA and at last lead to autoimmune diseases.

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Memo

Memo:
国家自然科学基金资助项目（编号：30870947）
Last Update: 2012-06-11