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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2025 06

Page:

1044-1050

Research Field:

Publishing date:

Info

Title:

Advances in macrophage polarisation in gliomas

Author(s):

HAN Hongxi¹; 2; SU Yuanping¹; 2; TANG Beiyan¹; 2; YU Haijia¹; 2; LIU Weiguo³; YUAN Guoqiang¹; 2; 4

1.Department of Neurosurgery,the Second Hospital of Lanzhou University,Gansu Lanzhou 730000,China£»2.Laboratory of Neurosurgery,the Second Hospital of Lanzhou University,Gansu Lanzhou 730000,China£»3.School of Basic Medical Sciences,Lanzhou University,Gansu

Keywords:

glioma; macrophage polarisation; tumour immunity; therapy

PACS:

R739.4

DOI:

10.3969/j.issn.1672-4992.2025.06.023

Abstract:

Glioma,as a refractory primary tumor of the central nervous system,is characterized by high invasiveness,native angiogenesis,blood-brain barrier restriction,and tumor resistance.Traditional surgical resection plus chemoradiotherapy can not improve the clinical efficacy and postoperative survival rate well,so seeking more efficient novel therapies is currently the focus of glioma research.In this paper,glioma inhibitory microenvironment is used as the entry point to explore the different polarization states of the largest number of macrophages in the glioma microenvironment,more comprehensively understand the relationship between the function of different macrophages and glioma,and provide ideas for targeted therapy of glioma.

References:

£Û1£Ý CHEN D,ZHANG X,LI Z,et al.Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages £ÛJ£Ý.Theranostics,2021,11(3):1016-1030.
£Û2£Ý CHEN Z,HAMBARDZUMYAN D.Immune microenvironment in glioblastoma subtypes £ÛJ£Ý.Front Immunol,2018,9:1004.
£Û3£Ý HUANG R,KANG T,CHEN S.The role of tumor-associated macrophages in tumor immune evasion £ÛJ£Ý.J Cancer Res Clin Oncol,2024,150(5):238.
£Û4£Ý BARTHEL L,HADAMITZKY M,DAMMANN P,et al.Glioma:molecular signature and crossroads with tumor microenvironment £ÛJ£Ý.Cancer Metastasis Rev,2022,41(1):53-75.
£Û5£Ý KHAN F,PANG L,DUNTERMAN M,et al.Macrophages and microglia in glioblastoma:heterogeneity,plasticity,and therapy £ÛJ£Ý.J Clin Invest,2023,133(1):e163446.
£Û6£Ý KRISHNA S,CHOUDHURY A,KEOUGH MB,et al.Glioblastoma remodelling of human neural circuits decreases survival £ÛJ£Ý.Nature,2023,617(7961):599-607.
£Û7£Ý CHEN Z,FENG X,HERTING CJ,et al.Cellular and molecular identity of tumor-associated macrophages in glioblastoma £ÛJ£Ý.Cancer Res,2017,77(9):2266-2278.
£Û8£Ý URBANTAT RM,JELGERSMA C,BRANDENBURG S,et al.Tumor-associated microglia/macrophages as a predictor for survival in glioblastoma and temozolomide-induced changes in CXCR2 signaling with new resistance overcoming strategy by combination therapy £ÛJ£Ý.Int J Mol Sci,2021,22(20):11180.
£Û9£Ý HAMBARDZUMYAN D,GUTMANN DH,KETTENMANN H.The role of microglia and macrophages in glioma maintenance and progression £ÛJ£Ý.Nat Neurosci,2016,19(1):20-27.
£Û10£Ý VECCHIARELLI HA,TREMBLAY M.Local translation in microglial processes £ÛJ£Ý.Nat Neurosci,2023,26(7):1140-1142.
£Û11£Ý BORST K,DUMAS AA,PRINZ M.Microglia:Immune and non-immune functions £ÛJ£Ý.Immunity,2021,54(10):2194-2208.
£Û12£Ý HINSHAW DC,SHEVDE LA.The tumor microenvironment innately modulates cancer progression £ÛJ£Ý.Cancer Res,2019,79(18):4557-4566.
£Û13£Ý HE Z,ZHANG S.Tumor-associated macrophages and their functional transformation in the hypoxic tumor microenvironment £ÛJ£Ý.Front Immunol,2021,12:741305.
£Û14£Ý NATHAN CF,MURRAY HW,WIEBE ME,et al.Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity £ÛJ£Ý.J Exp Med,1983,158(3):670-689.
£Û15£Ý LI W,YE Q,JIANG Z,et al.A cross-linked macropore hydrogel based on M1 macrophage lysate and alginate regulates tumor-associated macrophages for the treatment of melanoma £ÛJ£Ý.Int J Biol Macromol,2024,269(Pt 2):132089.
£Û16£Ý JIANG S,LI W,YANG J,et al.Cathepsin B-responsive programmed brain targeted delivery system for chemo-immunotherapy combination therapy of glioblastoma £ÛJ£Ý.ACS Nano,2024,18(8):6445-6462.
£Û17£Ý ELKIN M.Role of heparanase in macrophage activation £ÛJ£Ý.Adv Exp Med Biol,2020,1221:445-460.
£Û18£Ý STEIN M,KESHAV S,HARRIS N,et al.Interleukin 4 potently enhances murine macrophage mannose receptor activity:a marker of alternative immunologic macrophage activation £ÛJ£Ý.J Exp Med,1992,176(1):287-292.
£Û19£Ý CORNICE J,VERZELLA D,ARBORETTO P,et al.NF-¦ÊB:Governing macrophages in cancer £ÛJ£Ý.Genes (Basel),2024,15(2):197.
£Û20£Ý PE¦rA-ROMERO AC,ORENES-PI¦rERO E.Dual effect of immune cells within tumour microenvironment:Pro- and anti-tumour effects and their triggers £ÛJ£Ý.Cancers (Basel),2022,14(7):1681.
£Û21£Ý SHI T,ZHANG Y,WANG Y,et al.DKK1 promotes tumor immune evasion and impedes anti-PD-1 treatment by inducing immunosuppressive macrophages in gastric cancer £ÛJ£Ý.Cancer Immunol Res,2022,10(12):1506-1524.
£Û22£Ý ZHOU P,LI Q,SU S,et al.Interleukin 37 suppresses M1 macrophage polarization through inhibition of the Notch1 and nuclear factor kappa B pathways £ÛJ£Ý.Front Cell Dev Biol,2020,8:56.
£Û23£Ý LI M,YANG Y,XIONG L,et al.Metabolism,metabolites,and macrophages in cancer £ÛJ£Ý.J Hematol Oncol,2023,16(1):80.
£Û24£Ý BRUNI D,ANGELL HK,GALON J.The immune contexture and immunoscore in cancer prognosis and therapeutic efficacy £ÛJ£Ý.Nat Rev Cancer,2020,20(11):662-680.
£Û25£Ý ZHANG L,SHI P,JIN P,et al.Ganodermanontriol regulates tumor-associated M2 macrophage polarization in gastric cancer £ÛJ£Ý.Aging (Albany NY),2024,16(2):1390-1398.
£Û26£Ý TAFECH A,ST¦IPHANOU A.On the importance of acidity in cancer cells and therapy £ÛJ£Ý.Biology (Basel),2024,13(4):225.
£Û27£Ý WENES M,SHANG M,DI MATTEO M,et al.Macrophage metabolism controls tumor blood vessel morphogenesis and metastasis £ÛJ£Ý.Cell Metabolism,2016,24(5):701-715.
£Û28£Ý MANTOVANI A,ALLAVENA P.The interaction of anticancer therapies with tumor-associated macrophages £ÛJ£Ý.J Exp Med,2015,212(4):435-445.
£Û29£Ý CANLI ¦Z,NICOLAS AM,GUPTA J,et al.Myeloid cell-derived reactive oxygen species induce epithelial mutagenesis £ÛJ£Ý.Cancer Cell,2017,32(6):869-883.e865.
£Û30£Ý XU D,WANG Y,WU J,et al.ECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway £ÛJ£Ý.Cell Death Dis,2021,12(2):162.
£Û31£Ý GORDON S,MARTINEZ FO.Alternative activation of macrophages:mechanism and functions £ÛJ£Ý.Immunity,2010,32(5):593-604.
£Û32£Ý MURAILLE E,LEO O,MOSER M.TH1/TH2 paradigm extended:macrophage polarization as an unappreciated pathogen-driven escape mechanism£ÛJ£Ý.Front Immunol,2014,5:603.
£Û33£Ý SICA A,MANTOVANI A.Macrophage plasticity and polarization:in vivo veritas £ÛJ£Ý.J Clin Invest,2012,122(3):787-795.
£Û34£Ý SCHLEICHER U,PADUCH K,DEBUS A,et al.TNF-mediated restriction of arginase 1 expression in myeloid cells triggers type 2 NO synthase activity at the site of infection £ÛJ£Ý.Cell Rep,2016,15(5):1062-1075.
£Û35£Ý MURRAY PJ.Macrophage polarization £ÛJ£Ý.Annu Rev Physiol,2017,79:541-566.
£Û36£Ý MA Q,LONG W,XING C,et al.Corrigendum:PHF20 promotes glioblastoma cell malignancies through a WISP1/BGN-dependent pathway £ÛJ£Ý.Front Oncol,2023,13:1157694.
£Û37£Ý ZHU CX,YAN K,CHEN L,et al.Targeting OXCT1-mediated ketone metabolism reprograms macrophages to promote antitumor immunity via CD8(+) T cells in hepatocellular carcinoma £ÛJ£Ý.J Hepatol£Û2024-05-15£Ý.https://pubmed.ncbi.nlm.nih.gov/38759889/.DOI:10.1016/j.jhep.2024.05.007.
£Û38£Ý Îâ´ÓÑÏ£¬Â¥ÃÀÇ壬¼ÖÓñ£¬µÈ.Ö×ÁöÏà¹Ø¾ÞÊÉϸ°ûÑо¿½øÕ¹£ÛJ£Ý.ÏÖ´úÖ×Áöҽѧ£¬2020,28£¨3£©£º508-512. WU Congyan£¬LOU Meiqing£¬JIA Yu£¬et al.Research progression of tumor-associated macrophage£ÛJ£Ý.Modern Oncology,2020,28£¨3£©£º508-512.
£Û39£Ý TANG K,ZHANG H,DENG J,et al.Ammonia detoxification promotes CD8(+) T cell memory development by urea and citrulline cycles £ÛJ£Ý.Nat Immunol,2023,24(1):162-173.
£Û40£Ý WANG H,WANG X,ZHANG X,et al.The promising role of tumor-associated macrophages in the treatment of cancer £ÛJ£Ý.Drug Resist Updat,2024,73:101041.
£Û41£Ý TANG J,MING L,QIN F,et al.The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients £ÛJ£Ý.Immunobiology,2024,229(3):152805.
£Û42£Ý PAN Z,ZHAO R,LI B,et al.EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3£ÛJ£Ý.Mol Cancer,2022,21(1):16.
£Û43£Ý KREATSOULAS D,BOLYARD C,WU BX,et al.Translational landscape of glioblastoma immunotherapy for physicians:guiding clinical practice with basic scientific evidence £ÛJ£Ý.J Hematol Oncol,2022,15(1):80.
£Û44£Ý LI Z,FU WJ,CHEN XQ,et al.Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization £ÛJ£Ý.J Exp Clin Cancer Res,2022,41(1):74.
£Û45£Ý HUANG X,LIN R,LIU H,et al.Resatorvid (TAK-242) ameliorates ulcerative colitis by modulating macrophage polarization and T helper cell balance via TLR4/JAK2/STAT3 signaling pathway £ÛJ£Ý.Inflammation£Û2024-05-18£Ý.https://pubmed.ncbi.nlm.nih.gov/38760646/.DOI:10.1007/s10753-024-02028-z.
£Û46£Ý LIU M,LIANG W,SU Y,et al.COL8A1 is a potential prognostic biomarker associated with migration,proliferation,and tumor microenvironment in glioma £ÛJ£Ý.Exp Cell Res,2024,439(1):114076.
£Û47£Ý PARK JE,DUTTA B,TSE SW,et al.Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift £ÛJ£Ý.Oncogene,2019,38(26):5158-5173.
£Û48£Ý YANG YE,HU MH,ZENG YC,et al.IL-33/NF-¦ÊB/ST2L/Rab37 positive-feedback loop promotes M2 macrophage to limit chemotherapeutic efficacy in lung cancer £ÛJ£Ý.Cell Death Dis,2024,15(5):356.
£Û49£Ý BOUTILIER AJ,ELSAWA F.Macrophage polarization states in the tumor microenvironment £ÛJ£Ý.Int J Mol Sci,2021,22(13):6995.
£Û50£Ý LANKADASARI MB,MUKHOPADHYAY P,MOHAMMED S,et al.TAMing pancreatic cancer:combat with a double edged sword £ÛJ£Ý.Mol Cancer,2019,18(1):48.
£Û51£Ý ÕÔÀ¥,ʱÈÙ³¼,çѺéÃ÷.Ö×ÁöÏà¹Ø¾ÞÊÉϸ°ûµÄÖ¬ÖÊ´úлÖرà³Ì£ÛJ£Ý.ËÄ´¨´óѧѧ±¨(ҽѧ°æ),2021,52(01):45-49. ZHAO Kun£¬SHI Rongchen£¬MIAO Hongming.A review of the lipid metabolism reprogramming in tumor associated macrophages£ÛJ£Ý.J Sichuan Univ(Med Sci),2021,52(01):45-49.
£Û52£Ý IYER S,ENMAN M,SAHAY P,et al.Novel therapeutics to treat chronic pancreatitis:targeting pancreatic stellate cells and macrophages £ÛJ£Ý.Expert Rev Gastroenterol Hepatol,2024,18(4-5):171-183.
£Û53£Ý YANG F,ZHANG D,JIANG H,et al.Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy £ÛJ£Ý.Sci Transl Med,2023,15(683):eabq3558.

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