|Table of Contents|

Clincicopathologic characteristics analysis of a case of thyroid-like follicular renal cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 06
Page:
960-968
Research Field:
Publishing date:

Info

Title:
Clincicopathologic characteristics analysis of a case of thyroid-like follicular renal cell carcinoma
Author(s):
SHI Wenya; WANG Nana; CHANG Wenli; SI Hang; LIU Susu; ZHANG Qian
Department of Pathology,Binzhou Medical University Hospital,Shandong Binzhou 256600,China.
Keywords:
follicular; renal cell carcinoma; diagnosis; immunohistochemistry
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2025.06.011
Abstract:
Objective:To explore the clinicopathologic features of thyroid-like follicular renal cell carcinoma (TLFRCC),including diagnosis and treatment.Methods:One case of clinical data of TLFRCC was collected and examined by HE staining and immunohistochemistry.The clinicopathologic features of thyroid-like follicular renal cell carcinoma were analyzed in combination with 41 cases reported in domestic and foreign literatures.Results:A 76-year-old male patient was diagnosed with thyroid-like follicular renal cell carcinoma on the right side.The tumor diameter was 2.6 centimetre and had envelope and clear boundary under the microscopic.The tumor cells showed different sizes of thyroid follicle-like structure filled with eosinophilic glia and some areas were solid sheet arrangement.The morphology of tumor cells was columnar and cuboidal.The nucleus was round and the nuclear atypia was not obvious,also was the nucleolus.Nuclear division was not observed under the microscope.Immunohistochemical results indicated that tumor cells were positive for CK,Vimentin,E-cadherin,EMA,PAX-8 and CK19,including CK7(strong positive) and SDHB (plasma+).While negative results were as follows：CA-IX,CD10,P504s,CD117,Ksp-cadherin,TFE,Tg,TTF-1,CK20,RCC,ALK,Syn and CgA.The proliferation index of Ki-67 was about 1%~2%.Conclusion:TLFRCC is a rare and highly differentiated malignant tumor with thyroid-like follicular structure under the microscope.The correct diagnosis should be combined with clinical manifestations,imaging examination and pathological features.At present,nephrectomy is the best treatment.

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Memo

Memo:
山东省自然科学基金(编号:ZR2015HL085);山东省医药卫生科技发展项目(编号:202201040792);滨州医学院科研计划(编号:BY2020KJ06)
Last Update: 1900-01-01