|Table of Contents|

Significance of ETV6-NTRK3 gene fusion in pathological diagnosis of salivary secretory carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 05
Page:
822-827
Research Field:
Publishing date:

Info

Title:
Significance of ETV6-NTRK3 gene fusion in pathological diagnosis of salivary secretory carcinoma
Author(s):
XUE Jing1; DU Juan2; MA Zhiping1; MIAO Na1; SU Liping1; CUI Wenli1; ZHANG Wei1
1.Department of Pathology,the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830054,China;2.School of First Clinical Medicine,Xinjiang Medical University,Xinjiang Urumqi 830011,China.
Keywords:
salivary; secretory carcinoma; Pan-TRK protein; ETV6-NTRK3 gene fusion
PACS:
R739.8
DOI:
10.3969/j.issn.1672-4992.2025.05.015
Abstract:
Objective：To explore the value of ETV6-NTRK3 gene fusion in clinicopathological diagnosis of salivary secretory carcinoma (SSC).Methods：79 cases of SSC and other low-grade salivary tumors were collected from the department of pathology of our hospital,including 7 cases of SSC,10 cases of salivary acinar cell carcinoma,10 cases of mucoepidermoid carcinoma and 1 case of breast SC as control.The clinicopathological information were collected to observe the morphological features.The expression of Pan-TRK,S-100,SOX-10,DOG-1,Mammaglobin,GCDFP-15,CK7,Ki-67 was detected by immunohistochemistry,and the ETV6-NTRK3 gene fusion was detected by fluorescence in situ hybridization (FISH).Results：Among the 7 patients with SSC,there were 4 males and 3 females,aged 21~84 years.In 7 cases of SSC and 1 case of breast SC samples,Pan-TRK,S-100 and SOX-10 were diffusely strongly positive,CK7,Mammaglobin and GCDFP-15 were partially positive,DOG-1 was negative,and Ki-67 proliferation index was 8%~20%.ETV6-NTRK3 gene fusion was positive in 6 out of 7 cases of SSC detected by FISH.Conclusion:SSC is a low-grade malignant salivary tumor.The detection of morphological features and immunohistochemical techniques is of great value in the preliminary screening and differential diagnosis of SSC.The detection of ETV6-NTRK3 gene fusion by FISH is of great clinical significance for definite diagnosis and NTRK targeted drug therapy.

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