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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2025 04

Page:

641-647

Research Field:

Publishing date:

Info

Title:

Relationship between cardiometabolic index and neutrophil/lymphocyte ratio and prognosis of patients with colorectal cancer

Author(s):

REN Xuekang; ZHU Shaogong; XIA Yunzhan

Department of General Surgery,The Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine(Zhengzhou People¡¯s Hospital),Henan Zhengzhou 450003,China.

Keywords:

colorectal cancer; cardiometabolic index; neutrophil/lymphocyte ratio; prognosis

PACS:

R735.3

DOI:

10.3969/j.issn.1672-4992.2025.04.014

Abstract:

Objective:To investigate the relationship between cardiometabolic index (CMI) and preoperative neutrophil/lymphocyte ratio (NLR) and the prognosis of patients with colorectal cancer (CRC).Methods:Choose 107 cases of CRC patients as the research object in our hospital which performed radical resection of CRC.Collect patients' gender,age,tumor size,location,degree of differentiation,CMI,preoperative NLR level and other data.The Cut-off values of CMI and NLR were selected by ROC curve,the patients were divided into two groups and the clinicopathological characteristics of patients in different CMI and NLR groups and their relationship with overall survival (OS) were compared.By combining CMI and NLR levels,Kaplan-Meier method was used to draw the OS survival curve of patients with different CMI and NLR levels,and explore their relationship with the prognosis of CRC patients.Multivariate Cox proportional hazards regression was used to analyze the prognostic factors of patients with CRC.Results:A total of 107 patients with CRC were enrolled.Patients in the high CMI group had more lymph node metastasis (P=0.002),primary metastasis (P=0.003),poorly differentiated tumors (P=0.001),and higher proportion of TNM stage ¢ò-¢ô (P=0.002).Patients in the high NLR group had more lymph node metastasis (P£¼0.001),primary metastasis (P=0.001),poorly differentiated tumors (P=0.042),and higher proportion of TNM stage ¢ò-¢ô(P£¼0.001).OS in patients with low CMI group was higher than that of high CMI group of patients (¦Ö2= 26.32,P£¼0.001).OS in patients with low NLR group was higher than that of high NLR group of patients (¦Ö2= 27.61,P£¼0.001).By combining CMI and NLR levels,patients with both CMI>1.435 and NLR>3.65 had lower OS and poor prognosis.Patients with both CMI¡Ü1.435 and NLR¡Ü3.65 had higher OS and better prognosis (P£¼0.001).Tumor size,differentiation degree and the level of CMI and preoperative NLR are independent risk factors for postoperative outcomes in CRC patients (all P£¼0.05).Conclusion:Preoperative CMI and NLR levels are closely related to the prognosis of patients with CRC.The combination of CMI and NLR levels and dynamic monitoring can help to provide reference for the prognosis of patients with CRC.

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