«Previous Article|Table of Contents|Next Article»

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2025 03

Page:

501-508

Research Field:

Publishing date:

Info

Title:

Research progress on the relationship between bone marrow-derived suppressor cells and glioblastoma metabolism

Author(s):

ZHANG Yan; WANG Yulong; BAI Zetong; GUO Yansong; LI Lin; SHAO Jiang; WANG Yan; ZHENG Kebin

Department of Neurosurgery,Affiliated Hospital of Hebei University,Hebei Baoding 071000,China.

Keywords:

MDSCs; metabolism; immunosuppression; glioblastoma; tumor microenvironment; immunotherapy

PACS:

R739.4

DOI:

10.3969/j.issn.1672-4992.2025.03.023

Abstract:

Glioblastoma (GBM) is one of the most aggressive primary tumors of the central nervous system.Currently,the treatment for GBM is still surgical resection and adjuvant chemoradiotherapy,but the prognosis is poor.Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population composed of myeloid progenitor cells and progenitor cells at different stages of differentiation,which play an important role in tumor immunosuppression.Therefore,MDSCs have received a lot of attention.The study of the role of MDSCs in tumors is expected to lead to new strategies for the treatment of GBM.We summarized the sources and characteristics of MDSCs,briefly reviewed the immunosuppressive capacity of MDSCs and the therapeutic strategies for MDSCs.The paper has the emphasis on the effect of MDSCs on GBM metabolism and its relationship with GBM growth and invasion.

References:

£Û1£Ý REN R,XIONG C,MA R,et al.The recent progress of myeloid-derived suppressor cell and its targeted therapies in cancers £ÛJ£Ý.MedComm,2023,4(4):e323.
£Û2£Ý RAYCHAUDHURI B,RAYMAN P,IRELAND J,et al.Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma£ÛJ£Ý.Neuro-Oncology,2011,13(6):591-599.
£Û3£Ý KAMRAN N,KADIYALA P,SAXENA M,et al.Immunosuppressive myeloid cells' blockade in the glioma microenvironment enhances the efficacy of immune-stimulatory gene therapy £ÛJ£Ý.Molecular Therapy,2017,25(1):232-248.
£Û4£Ý VEGLIA F,SANSEVIERO E,GABRILOVICH DI.Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity£ÛJ£Ý.Nature Reviews Immunology,2021,21(8):485-498.
£Û5£Ý KUMAR V,PATEL S,TCYGANOV E,et al.The nature of myeloid-derived suppressor cells in the tumor microenvironment £ÛJ£Ý.Trends in Immunology,2016,37(3):208-220.
£Û6£Ý HEGDE S,LEADER AM,MERAD M.MDSC:Markers,development,states,and unaddressed complexity £ÛJ£Ý.Immunity,2021,54(5):875-884.
£Û7£Ý VEGLIA F,PEREGO M,GABRILOVICH D.Myeloid-derived suppressor cells coming of age £ÛJ£Ý.Nature Immunology,2018,19(2):108-119.
£Û8£Ý MASTIO J,CONDAMINE T,DOMINGUEZ G,et al.Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs£ÛJ£Ý.Journal of Experimental Medicine,2019,216(9):2150-2169.
£Û9£Ý KWAK T,WANG F,DENG H,et al.Distinct populations of immune-suppressive macrophages differentiate from monocytic myeloid-derived suppressor cells in cancer£ÛJ£Ý.Cell Reports,2020,33(13):108571.
£Û10£Ý LAKSHMANACHETTY S,CRUZ-CRUZ J,HOFFMEYER E,et al.New insights into the multifaceted role of myeloid-derived suppressor cells (MDSCs) in high-grade gliomas:From metabolic reprograming,immunosuppression,and therapeutic resistance to current strategies for targeting MDSCs £ÛJ£Ý.Cells,2021,10(4):893.
£Û11£Ý LOCARNO CV,SIMONELLI M,CARENZA C,et al.Role of myeloid cells in the immunosuppressive microenvironment in gliomas £ÛJ£Ý.Immunobiology,2020,225(1):151853.
£Û12£Ý ALSHETAIWI H,PERVOLARAKIS N,MCINTYRE LL,et al.Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics £ÛJ£Ý.Science Immunology,2020,5(44):eaay6017.
£Û13£Ý UGOLINI A,TYURIN VA,TYURINA YY,et al.Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer £ÛJ£Ý.JCI Insight,2020,5(15):e138581.
£Û14£Ý BIZYMI N,MATTHAIOU AM,MAVROUDI I,et al.Immunomodulatory actions of myeloid-derived suppressor cells in the context of innate immunity £ÛJ£Ý.Innate Immunity,2023,30(1):2-10.
£Û15£Ý LEPPER A,BITSCH R,¦ZZBAY KURT FG,et al.Melanoma patients with immune-related adverse events after immune checkpoint inhibitors are characterized by a distinct immunological phenotype of circulating T cells and M-MDSCs £ÛJ£Ý.OncoImmunology,2023,12(1):2247303.
£Û16£Ý SZEFEL J,DANIELAK A,KRUSZEWSKI WJ.Metabolic pathways of L-arginine and therapeutic consequences in tumors £ÛJ£Ý.Adv Med Sci,2019,64(1):104-110.
£Û17£Ý DAR AA,PATIL RS,PRADHAN TN,et al.Myeloid-derived suppressor cells impede T cell functionality and promote Th17 differentiation in oral squamous cell carcinoma £ÛJ£Ý.Cancer Immunology,Immunotherapy,2020,69(6):1071-1086.
£Û18£Ý XU C,XIAO M,LI X,et al.Origin,activation,and targeted therapy of glioma-associated macrophages £ÛJ£Ý.Frontiers in Immunology,2022,13:974996.
£Û19£Ý PINTON L,MASETTO E,VETTORE M,et al.The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion £ÛJ£Ý.Journal for ImmunoTherapy of Cancer,2019,7(1):58.
£Û20£Ý GABRUSIEWICZ K,COLWELL NA,HEIMBERGER AB.The role of myeloid-derived suppressor cells in immunosuppression in brain tumors £ÛM£Ý.Translational Immunotherapy of Brain Tumors,2017:63-82.
£Û21£Ý UGEL S,DE SANCTIS F,MANDRUZZATO S,et al.Tumor-induced myeloid deviation:when myeloid-derived suppressor cells meet tumor-associated macrophages £ÛJ£Ý.Journal of Clinical Investigation,2015,125(9):3365-3376.
£Û22£Ý FORTIN C,HUANG X,YANG Y.NK cell response to vaccinia virus is regulated by myeloid-derived suppressor cells £ÛJ£Ý.The Journal of Immunology,2012,189(4):1843-1849.
£Û23£Ý BRUNO A,MORTARA L,BACI D,et al.Myeloid derived suppressor cells interactions with natural killer cells and pro-angiogenic activities:roles in tumor progression £ÛJ£Ý.Frontiers in Immunology,2019,10:771.
£Û24£Ý LEE-CHANG C,RASHIDI A,MISKA J,et al.Myeloid-derived suppressive cells promote B cell-mediated immunosuppression via transfer of PD-L1 in glioblastoma £ÛJ£Ý.Cancer Immunology Research,2019,7(12):1928-1943.
£Û25£Ý BEKIC M,TOMIC S.Myeloid-derived suppressor cells in the therapy of autoimmune diseases £ÛJ£Ý.European Journal of Immunology,2023,53(12):e2250345.
£Û26£Ý PARK MJ,LEE SH,KIM EK,et al.Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice £ÛJ£Ý.Scientific Reports,2018,8(1):3753.
£Û27£Ý STOCKWELL BR,FRIEDMANN ANGELI JP,BAYIR H,et al.Ferroptosis:A regulated cell death nexus linking metabolism,redox biology,and disease £ÛJ£Ý.Cell,2017,171(2):273-285.
£Û28£Ý KIM R,TAYLOR D,VONDERHEIDE RH,et al.Ferroptosis of immune cells in the tumor microenvironment £ÛJ£Ý.Trends in Pharmacological Sciences,2023,44(8):542-552.
£Û29£Ý ZHANG Y,SONG J,ZHAO Z,et al.Single-cell transcriptome analysis reveals tumor immune microenvironment heterogenicity and granulocytes enrichment in colorectal cancer liver metastases £ÛJ£Ý.Cancer Letters,2020,470:84-94.
£Û30£Ý XU S,WANG Z,YE J,et al.Identification of iron metabolism-related genes as prognostic indicators for lower-grade glioma £ÛJ£Ý.Frontiers in Oncology,2021,11:729103.
£Û31£Ý JAKSCH-BOGENSPERGER H,SPIEGL-KREINECKER S,AROSIO P,et al.Ferritin in glioblastoma £ÛJ£Ý.British Journal of Cancer,2020,122(10):1441-1444.
£Û32£Ý KIM R,HASHIMOTO A,MARKOSYAN N,et al.Ferroptosis of tumour neutrophils causes immune suppression in cancer £ÛJ£Ý.Nature,2022,612(7939):338-346.
£Û33£Ý KAPRALOV AA,YANG Q,DAR HH,et al.Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death £ÛJ£Ý.Nat Chem Biol,2020,16(3):278-290.
£Û34£Ý LI L,LI C,WANG S,et al.Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype £ÛJ£Ý.Cancer Research,2016,76(7):1770-1780.
£Û35£Ý GUO X,QIU W,LIU Q,et al.Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten pathways £ÛJ£Ý.Oncogene,2018,37(31):4239-4259.
£Û36£Ý CHEN CC,LIU L,MA F,et al.Elucidation of exosome migration across the blood-brain barrier model in vitro £ÛJ£Ý.Cellular and Molecular Bioengineering,2016,9(4):509-529.
£Û37£Ý FLORES RR,CLAUSON CL,CHO J,et al.Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-¦ÊB-dependent mechanism £ÛJ£Ý.Aging Cell,2017,16(3):480-487.
£Û38£Ý HUSAIN Z,HUANG Y,SETH P,et al.Tumor-derived lactate modifies antitumor immune response:Effect on myeloid-derived suppressor cells and NK cells £ÛJ£Ý.The Journal of Immunology,2013,191(3):1486-1495.
£Û39£Ý CHIU DKC,XU IMJ,LAI RKH,et al.Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26 £ÛJ£Ý.Hepatology,2016,64(3):797-813.
£Û40£Ý HALMA MTJ,TUSZYNSKI JA,MARIK PE.Cancer metabolism as a therapeutic target and review of interventions £ÛJ£Ý.Nutrients,2023,15(19):4245.
£Û41£Ý JIAN SL,CHEN WW,SU YC,et al.Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis £ÛJ£Ý.Cell Death & Disease,2017,8(5):e2779.
£Û42£Ý WANG Y,JIA A,BI Y,et al.Metabolic regulation of myeloid-derived suppressor cell function in cancer £ÛJ£Ý.Cells,2020,9(4):1011.
£Û43£Ý LI W,TANIKAWA T,KRYCZEK I,et al.Aerobic glycolysis controls myeloid-derived suppressor cells and tumor immunity via a specific CEBPB isoform in triple-negative breast cancer £ÛJ£Ý.Cell Metabolism,2018,28(1):87-103.e6.
£Û44£Ý ZENG D,LONG H,ZHU B.Antitumor effects of targeting myeloid-derived suppressive cells £ÛJ£Ý.Translational Cancer Research,2020,9(9):5787-5797.
£Û45£Ý ZHAO H,TENG D,YANG L,et al.Myeloid-derived itaconate suppresses cytotoxic CD8(+) T cells and promotes tumour growth £ÛJ£Ý.Nat Metab,2022,4(12):1660-1673.
£Û46£Ý GARNIER D,RENOULT O,ALVES-GUERRA MC,et al.Glioblastoma stem-like cells,metabolic strategy to kill a challenging target £ÛJ£Ý.Frontiers in Oncology,2019,9:118.
£Û47£Ý WU WC,SUN HW,CHEN J,et al.Immunosuppressive immature myeloid cell generation is controlled by glutamine metabolism in human cancer £ÛJ£Ý.Cancer Immunology Research,2019,7(10):1605-1618.
£Û48£Ý OH MH,SUN IH,ZHAO L,et al.Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells £ÛJ£Ý.Journal of Clinical Investigation,2020,130(7):3865-3884.
£Û49£Ý LI Z,KANG Y.Lipid metabolism fuels cancer's spread £ÛJ£Ý.Cell Metab,2017,25(2):228-230.
£Û50£Ý YANG Y,CAO Y.The impact of VEGF on cancer metastasis and systemic disease £ÛJ£Ý.Seminars in Cancer Biology,2022,86:251-261.
£Û51£Ý WANG J,SU X,YANG L,et al.The influence of myeloid-derived suppressor cells on angiogenesis and tumor growth after cancer surgery £ÛJ£Ý.International Journal of Cancer,2016,138(11):2688-2699.
£Û52£Ý RIDGE SM,SULLIVAN FJ,GLYNN SA.Mesenchymal stem cells:key players in cancer progression £ÛJ£Ý.Molecular Cancer,2017,16(1):31.
£Û53£Ý WEBER R,RIESTER Z,H¦aSER L,et al.IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma £ÛJ£Ý.Journal for ImmunoTherapy of Cancer,2020,8(2):e000949.
£Û54£Ý DE LEO A,UGOLINI A,VEGLIA F.Myeloid cells in glioblastoma microenvironment £ÛJ£Ý.Cells,2020,10(1):18.
£Û55£Ý PEEREBOOM DM,ALBAN TJ,GRABOWSKI MM,et al.Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells £ÛJ£Ý.JCI Insight,2019,4(22):e130748.
£Û56£Ý ALBAN TJ,BAYIK D,OTVOS B,et al.Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression £ÛJ£Ý.Frontiers in Immunology,2020,11:1191.
£Û57£Ý GREENE S,ROBBINS Y,MYDLARZ WK,et al.Inhibition of MDSC trafficking with SX-682,a CXCR1/2 inhibitor,enhances NK-cell immunotherapy in head and neck cancer models £ÛJ£Ý.Clinical Cancer Research,2020,26(6):1420-1431.
£Û58£Ý ZHU X,FUJITA M,SNYDER LA,et al.Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy £ÛJ£Ý.Journal of Neuro-Oncology,2010,104(1):83-92.

Memo

Memo:

ºÓ±±Ê¡×ÔÈ»¿Æѧ»ù½ð×ÊÖúÏîÄ¿£¨±àºÅ£ºH2023201032£©£»ºÓ±±Ê¡Õþ¸®×ÊÖúÁÙ´²Ò½Ñ§ÓÅÐãÈ˲ÅÅàÑøÏîÄ¿£¨±àºÅ£º361007£©

Common functions

Last Update: 1900-01-01