|Table of Contents|

Research progress on the role of DSC-2 in tumors of digestive system and other systemic cancers

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 03
Page:
487-493
Research Field:
Publishing date:

Info

Title:
Research progress on the role of DSC-2 in tumors of digestive system and other systemic cancers
Author(s):
YAN Peici1GUO Ran2LI Gang3HU Rui2WANG Xiangnan1HU Xiao1
1.Department of Pathophysiology,Hebei Medical University,Hebei Shijiazhuang 050017,China;2.The Second Affiliated Hospital of Hebei Medical University,Hebei Shijiazhuang 050061,China;3.Hebei Provincial People's Hospital,Hebei Shijiazhuang 050051,China.
Keywords:
DSC-2tumorsignaling pathwaymetastatic invasiontherapeutic target
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2025.03.021
Abstract:
Desmocollin-2 (DSC-2) is an important component of desmosomal proteins,playing a role in cell-to-cell adhesion at the cell membrane surface and serving as a key factor in cell adhesion.The dysregulation of DSC-2 expression is closely related to the pathological processes of many diseases,including oncological disorders.Studies have confirmed that the abnormal expression of DSC-2 is closely associated with the initiation and progression of cancer and often indicates an enhancement of tumor metastasis and invasiveness.This review summarizes the physiological functions of DSC-2 and the impact of its abnormal expression in different tumors of digestive system and other systems.The aim of this article is to elucidate the pathogenic mechanisms and clinical correlations of abnormal DSC-2 expression in oncological diseases,providing the necessary theoretical basis for the development and application of desmosomal protein family-related tumor evaluation indicators and clinical therapeutic targets.

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Memo

Memo:
National Natural Science Foundation of China(No.82103457);国家自然科学基金项目(编号:82103457);河北省自然科学基金(编号:H2023307028);河北省高等学校科学技术研究项目(编号:BJK2023025);河北省卫生健康委医学科学研究课题计划项目(编号:20240370)
Last Update: 1900-01-01