|Table of Contents|

Expression of HLA-DRB1 protein in hepatocellular carcinoma tissues and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 03
Page:
433-439
Research Field:
Publishing date:

Info

Title:
Expression of HLA-DRB1 protein in hepatocellular carcinoma tissues and its clinical significance
Author(s):
CHEN Kun1; LI Zihan2; ZHANG Xiaolin3; YANG Hui1; CAI Wenqing1; ZHAO Yubao4; DENG Yang1
1.School of Public Health,Shandong First Medical University,Shandong Jinan 250000,China;2.School of Medical Laboratory,Shandong Second Medical University,Shandong Weifang 261053,China;3.School of Radiology,Shandong First Medical University,Shandong Tai’an 271016,China;4.Department of Infectious Diseases,Second Affiliated Hospital of Shandong First Medical University,Shandong Tai’an 271000,China.
Keywords:
hepatocellular carcinoma; HLA-DRB1; immunohistochemistry; expression; prognosis
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2025.03.012
Abstract:
Objective:To investigate the expression of human leukocyte antigen-DRB1 (HLA-DRB1) in hepatocellular carcinoma (HCC) tissues and its clinical significance.Methods:HLA-DRB1 protein expression level in HCC tissues and adjacent tissues from 343 patients was assessed using immunohistochemistry,and clinicopathological characteristics of patients with different HLA-DRB1 expression levels were compared.Kaplan-Meier method was used to compare the overall survival (OS) and recurrence-free survival (RFS) of patients with different HLA-DRB1 expression levels.Cox proportional hazards regression was employed to analyze the factors influencing overall survival (OS) and recurrence-free survival (RFS) in HCC patients after hepatectomy.Results:The high expression rate of HLA-DRB1 protein in HCC tissues (47.23%) was significantly lower than that in adjacent tissues (79.59%,χ2=77.415,P＜0.001).HLA-DRB1 expression level was associated with AFP>400 μg/L,cirrhosis,no/incomplete capsule,microvascular invasion,and BCLC B/C stage (all P＜0.05).The OS rate (χ2=4.486,P=0.034) and RFS rate (χ2=15.446,P＜0.001) of HCC patients with high expression of HLA-DRB1 were significantly higher than those with low expression of HLA-DRB1.The high expression of HLA-DRB1 protein was an independent protective factors affecting postoperative OS （HR=0.727,95%CI：0.531~0.944，P=0.040）and RFS（HR=0.607,95%CI：0.454~0.811，P＜0.001） in HCC patients.Conclusion:The high expression rate of HLA-DRB1 protein in HCC tissues was notably lower than that in adjacent tissues,and high expression of HLA-DRB1 protein was significantly associated with good prognosis of HCC patients.

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Memo

Memo:
National Natural Science Foundation of China(No.82204111）；国家自然科学基金（编号：82204111）；山东省泰安市科技创新发展项目（编号：2021NS335）
Last Update: 1900-01-01