|Table of Contents|

Nutritional and inflammatory markers for predicting acute severe adverse events in patients with esophageal squamous cell carcinoma treated by radical radiotherapy and concurrent chemoradiotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 02
Page:
241-248
Research Field:
Publishing date:

Info

Title:
Nutritional and inflammatory markers for predicting acute severe adverse events in patients with esophageal squamous cell carcinoma treated by radical radiotherapy and concurrent chemoradiotherapy
Author(s):
DENG Jie; YANG Bo; SUN Xiang
Department of Oncology,the Third Affiliated Hospital of Anhui Medical University(Hefei First People's Hospital),Anhui Hefei 230001,China.
Keywords:
esophageal squamous cell carcinoma; radiotherapy; nutrition; inflammation; adverse events
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2025.02.011
Abstract:
Objective:To investigate the relationship between pre-treatment nutritional and inflammatory markers and grade≥3 acute severe adverse events in patients with esophageal squamous cell carcinoma treated by radical radiotherapy and concurrent chemoradiotherapy.Methods:The medical records of 98 patients with esophageal squamous cell carcinoma who underwent radical radiotherapy or concurrent chemoradiotherapy were retrospectively analyzed.Acute adverse events were assessed with the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 and toxicity criteria of the Radiation Therapy Oncology Group (RTOG).Grade ≥3 was considered as severe adverse events.The relationships between grade≥3 severe adverse events and pre-treatment nutritional and inflammatory parameters,including nutritional risk screening 2002 (NRS 2002),prognostic nutritional index (PNI),systemic immune-inflammation index (SII),neutrophil-to-lymphocyte ratio (NLR),platelet-to-albumin ratio (PAR) and system inflammation response index (SIRI) were evaluated in addition to patient and treatment factors.Logistic regression analyses were used to identify independent predictors of severe adverse events,and the receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of correlated markers in the multivariate logistic regression analysis for severe adverse events of radical radiotherapy and concurrent chemoradiotherapy.Results:In the 98 patients who underwent radical radiotherapy or concurrent chemoradiotherapy,26(26.5%) patients exhibited grade≥3 severe adverse events.On univariate analysis,tumor stage,concurrent chemotherapy,PNI,SII,NLR and SIRI were relevant to grade≥3 severe adverse events （P＜0.05）.Multivariate analysis revealed that PNI (P=0.012) and concurrent chemotherapy (P=0.013) independently predicted grade≥3 severe adverse events,while NRS 2002,SII,NLR,PAR,and SIRI did not （P＞0.05）.The ROC curve showed that the PNI had an area under the curve of 0.849 for predicting grade≥3 adverse events,indicating good predictive value.Conclusion:PNI and concurrent chemotherapy are independent predictive factor and influencing factor for acute severe adverse events in patients with esophageal squamous cell carcinoma treated with radical radiotherapy and concurrent chemoradiotherapy,however,NRS 2002,SII,NLR,PAR,SIRI are not.

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Memo

Memo:
安徽省合肥市卫生健康委2022年度应用医学研究重点项目（编号：Hwk2022zd001）
Last Update: 1900-01-01