|Table of Contents|

Expression and significance of EGR1 in prostate cancer tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2025 01
Page:
85-89
Research Field:
Publishing date:

Info

Title:
Expression and significance of EGR1 in prostate cancer tissues
Author(s):
YAN Delun1; SHEN Jing2; GONG Youjie2; MA Zhihou2; ZHU Yanan2; YU Na2; 3; HUA Haoming2; 3; HUANG Yan2; 4; WANG Hongqun2
1.Department of Surgery;2.Department of Pathology,the Third People's Hospital of Bengbu Affiliated to Bengbu Medical University,Anhui Bengbu 233099,China;3.Department of Pathology,the Second People's Hospital of Bengbu,Anhui Bengbu 233099,China;4.Department of Pathology,the Traditional Chinese Medicine Hospital of Bengbu City,Anhui Bengbu 233099,China.
Keywords:
prostate cancer; EGR1; AR; basal cells; differentiation
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2025.01.014
Abstract:
Objective:To explore the expression and significance of early growth response gene 1 (EGR1) in prostate cancer.Methods:The expression of EGR1 in prostate cancer tissues was detected using immunohistochemistry,observing under microscope,and statistically analysing.Results:The positive rate of EGR1 in prostate cancer were 30.7%(23/75),its expression was negatively correlated with AR,and was also observed in some apoptotic cells.The expression of EGR1 was lower than that of prostate cancer in normal tissues (P＜0.05),and was positive in the basal cells of some follicles/ducts,and in some interstitial fibroblasts.Conclusion:EGR1 may be related to the development of prostate cancer tissues and may be associated with apoptosis.EGR1 may be related to the development of basal cells and associated with the growth of fibroblasts.

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安徽省临床医学研究转化专项(编号：202204295107020051)
Last Update: 1900-01-01