|Table of Contents|

Research progress of regorafenib in the treatment of metastatic colorectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 22
Page:
4407-4412
Research Field:
Publishing date:

Info

Title:
Research progress of regorafenib in the treatment of metastatic colorectal cancer
Author(s):
JIN KexinWEI XiaoliBAI Yuxian
The Second Department of Internal Medicine,the Affiliated Cancer Hospital of Harbin Medical University,Heilongjiang Harbin 150081,China.
Keywords:
metastatic colorectal cancerregorafenibtargeted therapycombination therapyanti-angiogenesis
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2024.22.034
Abstract:
According to global cancer statistics 2022,the incidence and mortality of colorectal cancer are among the highest.Most patients are diagnosed in the middle and late stages and lose the chance of surgery.Individualized and precise treatment under the guidance of molecular typing is the current treatment strategy for metastatic colorectal cancer.Angiogenesis plays an essential role in tumor cell proliferation,vascular remodeling,cell invasion and metastasis.In recent years,many breakthroughs have been made in targeted therapy of colorectal cancer.As a new small-molecule targeting drug,regorafenib can simultaneously target multiple receptor sites,and has a significant effect in the treatment of advanced colorectal cancer,and has been approved as a third-line standard treatment for metastatic colorectal cancer.This article mainly reviews the latest research progress of regorafenib in metastatic colorectal cancer, in order to further benefit and clinical application of regorafenib.

References:

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