|Table of Contents|

Research progress of inducing anoikis for the treatment of hepatocellular carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 22
Page:
4385-4390
Research Field:
Publishing date:

Info

Title:
Research progress of inducing anoikis for the treatment of hepatocellular carcinoma
Author(s):
YE Songyun1; LI Tianzhu2
1.Department of General Surgery,the Affiliated Hospital of Chifeng University,Inner Mongolia Chifeng 024000,China;2.Molecular Medicine Research Center,School of Basic Medical Science,Chifeng University,Inner Mongolia Chifeng 024000,China.
Keywords:
hepatocellular carcinoma; anoikis; bioactive compounds; treatment
PACS:
R735.7
DOI:
10.3969/j.issn.1672-4992.2024.22.029
Abstract:
Tumor metastasis occurs in hepatocellular carcinoma (HCC),resulting in tumor progression and therapy failure.Anoikis is a mechanism of matrix detachment-induced apoptosis that inhibits the escape of tumor cells from the native extracellular matrix to other organs，thereby combating tumor metastasis.Deciphering the regulators and mechanism of anoikis in cancer metastasis is urgently needed to treat HCC.The article summarizes the current understanding of the molecular mechanism of anoikis regulation and relevant regulators involved in HCC cancer metastasis and discusses the therapeutic potential of pharmacological inducing anoikis in the treatment of HCC metastasis,suggesting that inducing anoikis by bioactive compounds is a promising therapeutic avenues in HCC.

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Memo

Memo:
National Natural Science Foundation of China(No.82060118);国家自然科学基金项目(编号：82060118);内蒙古自治区高等学校青年科技英才支持计划项目(编号：NJYT24032)
Last Update: 1900-01-01