|Table of Contents|

Research progress on the pathological mechanism of radiation-induced kidney injury

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 21
Page:
4189-4194
Research Field:
Publishing date:

Info

Title:
Research progress on the pathological mechanism of radiation-induced kidney injury
Author(s):
LIANG Hongying; TANG Yufu; ZHAN Jingming
Division of Radiology and Environmental Medicine,China Institute for Radiation Protection,Shanxi Taiyuan 030006,China.
Keywords:
ionizing radiation; radiotherapy; radiation-induced kidney injury; pathological mechanisms
PACS:
R730.55
DOI:
10.3969/j.issn.1672-4992.2024.21.032
Abstract:
Ionizing radiation is widely used in medical and industrial fields,such as radiotherapy and industrial radiography.The kidney is one of the most radiosensitive tissues and can be affected during radiotherapy for abdominal malignant tumors,causing clinical and pathological changes.The kidney is a vital organ in the human body,responsible for excreting metabolites and toxic chemicals,maintaining water balance and electrolyte balance,regulating blood pressure,and promoting erythropoiesis.At present,research on radiation-induced kidney injury is receiving increasing attention,but its pathological mechanism is complex and not fully clear,and there are no effective preventive or therapeutic interventions.This article reviews the research progress on histopathological changes and pathological mechanism of radiation-induced kidney injury,to better understand the occurrence and development of radiation-induced kidney injury,and provide reference for its early detection,prevention,and treatment.

References:

[1]CHENG H,CHEN L,HUANG M,et al.Hunting down NLRP3 inflammasome:An executioner of radiation-induced injury［J］.Front Immunol,2022,13:967989.
[2] A EID R,ALAA EDEEN M,SOLTAN MA,et al.Integration of ultrastructural and computational approaches reveals the protective effect of astaxanthin against BPA-induced nephrotoxicity［J］.Biomedicines,2023,11(2):421.
[3] AZZAM P,FRANCIS M,YOUSSEF T,et al.Crosstalk between SMPDL3b and NADPH oxidases mediates radiation-induced damage of renal podocytes［J］.Front Med(Lausanne),2021,8:732528.
[4] COHEN EP,ROBBINS MEC.Radiation nephropathy［J］.Semin Nephrol,2003,23(5):486-499.
[5] TRAN LK,MATUREN KE,FENG MU,et al.Renal remodeling after abdominal radiation therapy:parenchymal and functional changes［J］.AJR Am J Roentgenol,2014,203(2):192-198.
[6] KLAUS R,NIYAZI M,LANGE-SPERANDIO B.Radiation-induced kidney toxicity:molecular and cellular pathogenesis［J］.Radiat Oncol,2021,16(1):43.
[7] SAADAT I,SHAKIBAIE M,JOMEHZADEH A,et al.Radioprotective effect of Zinc nanoparticles on ionizing radiation-induced nephrotoxicity in mice［J］.Pharmacology,2023,108(1):101-110.
[8] LUXTON RW,KUNKLER PB.Radiation nephritis［J］.Acta Radiol Ther Phys Biol,1964,2:169-178.
[9] MEDHORA M,GAO F,GASPERETTI T,et al.Delayed effects of acute radiation exposure(Deare) in juvenile and old rats:Mitigation by lisinopril［J］.Health Physics,2019,116(4):529.
[10] SOLIMAN AF,SAIF-ELNASR M,ABDEL FATTAH SM.Platelet-rich plasma ameliorates gamma radiation-induced nephrotoxicity via modulating oxidative stress and apoptosis［J］.Life Sci,2019,219:238-247.
[11] PARKER GA,COHEN EP,LI N,et al.Radiation nephropathy in a nonhuman primate model of partial-body irradiation with minimal bone marrow sparing-Part 2:Histopathology,mediators,and mechanisms［J］.Health Phys,2019,116(3):409-425.
[12] ARATANI S,TAGAWA M,NAGASAKA S,et al.Radiation-induced premature cellular senescence involved in glomerular diseases in rats［J］.Sci Rep,2018,8(1):16812.
[13] ABDEL-MAGIED N,ELKADY AA.Possible curative role of curcumin and silymarin against nephrotoxicity induced by gamma-rays in rats［J］.Exp Mol Pathol,2019,111:104299.
[14] FOUAD D,ALHATEM H,ABDEL-GABER R,et al.Hepatotoxicity and renal toxicity induced by gamma-radiation and the modulatory protective effect of ficus carica in male albino rats［J］.Res Vet Sci,2019,125:24-35.
[15] DENG L,WANG S,LENG X,et al.Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy［J］.J Radiat Res,2023,64(5):769-782.
[16] KARAMI M,ASRI-REZAEI S,DORMANESH B,et al.Comparative study of radioprotective effects of selenium nanoparticles and sodium selenite in irradiation-induced nephropathy of mice model［J］.Int J Radiat Biol,2018,94(1):17-27.
[17] YILMAZ H,KARAKOC Y,TUMKAYA L,et al.The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation［J］.Hum Exp Toxicol,2022,41:9603271221143029.
[18] HASAN HF,ELGAZZAR EM,MOSTAFA DM.Diminazene aceturate extenuate the renal deleterious consequences of angiotensin-II induced by γ-irradiation through boosting ACE2 signaling cascade［J］.Life Sci,2020,253:117749.
[19] MAHRAN YF,AL-KHARASHI LA,ATAWIA RT,et al.Radioprotective effects of carvacrol and/or thymol against gamma irradiation-induced acute nephropathy:In silico and in vivo evidence of the involvement of insulin-like growth factor-1(IGF-1) and calcitonin gene-related peptide［J］.Biomedicines,2023,11(9):2521.
[20] ASKER ME,ALI SI,MOHAMED SH,et al.The efficacy of bone marrow-derived mesenchymal stem cells and/or erythropoietin in ameliorating kidney damage in gamma irradiated rats:Role of non-hematopoietic erythropoietin anti-apoptotic signaling［J］.Life Sci,2021,275:119388.
[21] BARAN M,YAY A,ONDER GO,et al.Hepatotoxicity and renal toxicity induced by radiation and the protective effect of quercetin in male albino rats［J］.Int J Radiat Biol,2022,98(9):1473-1483.
[22] ZHANG D,ZHANG S,HE Z,et al.Cytosine-phosphate-guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis［J］.J Transl Med,2023,21(1):679.
[23] CRDOVA-SNCHEZ BM,JOFFRE-TORRES A,JOACHN-SNCHEZ E,et al.Acute kidney injury in critically ill patients after oncological surgery:Risk factors and 1-year mortality［J］.Nephrology(Carlton),2021,26(12):965-971.
[24] KATSUTA T,MATSUURA K,KASHIWADO K.Analysis of chronic kidney disease after radiation therapy for gastric/duodenal mucosa-associated lymphoid tissue lymphoma［J］.Adv Radiat Oncol,2021,6(6):100788.
[25] LI Y,MIZUMOTO M,NITTA H,et al.Late changes in renal volume and function after proton beam therapy in pediatric and adult patients:Children show significant renal atrophy but deterioration of renal function is minimal in the long-term in both groups［J］.Cancers(Basel),2024,16(9):1634.
[26] DIEFFENBACH BV,LIU Q,MURPHY AJ,et al.Late-onset kidney failure in survivors of childhood cancer:a report from the Childhood Cancer Survivor Study［J］.Eur J Cancer,2021,155:216-226.
[27] MANSOURI I,SCHWARTZ B,VU-BEZIN G,et al.Risk of renal or urinary related hospitalization in survivors of childhood cancer:Results from the French childhood cancer survivor study［J］.Cancer Epidemiol Biomarkers Prev,2023,32(4):572-581.
[28] GAO F,DONG W,LIU P,et al.Molecular changes in miRNA in irradiated rat kidneys:Role of miR-34a and its vascular targets in the Notch pathway［J］.Radiat Res,2021,196(6):611-622.
[29] CHEN G,YU Z,ZHANG Y,et al.Radiation-induced gastric injury during radiotherapy:molecular mechanisms and clinical treatment［J］.J Radiat Res,2023,64(6):870-879.
[30] ABDELAZIZ RF,HUSSEIN AM,KOTOB MH,et al.Enhancement of radiation sensitivity by cathepsin L suppression in colon carcinoma cells［J］.Int J Mol Sci,2023,24(23):17106.
[31] PRIANTE G,GIANESELLO L,CEOL M,et al.Cell death in the kidney［J］.Int J Mol Sci,2019,20(14):3598.
[32] WANG Y,GAO T,WANG B.Application of mesenchymal stem cells for anti-senescence and clinical challenges［J］.Stem Cell Res Ther,2023,14(1):260.
[33] DE RUYSSCHER D,NIEDERMANN G,BURNET NG,et al.Radiotherapy toxicity［J］.Nat Rev Dis Primers,2019,5(1):13.
[34] KIM JE,CHO MH.Effects of multiwall carbon nanotubes on premature kidney aging:Biochemical and histological analysis［J］.Toxics,2023,11(4):373.
[35] BAER PC,KOCH B,GEIGER H.Kidney inflammation,injury and regeneration 2020［J］.Int J Mol Sci,2021,22(11):5589.
[36] KIM SR,JIANG K,OGRODNIK M,et al.Increased renal cellular senescence in murine high-fat diet:effect of the senolytic drug quercetin［J］.Transl Res,2019,213:112-123.
[37] YU Z,XU C,SONG B,et al.Tissue fibrosis induced by radiotherapy:current understanding of the molecular mechanisms,diagnosis and therapeutic advances［J］.J Transl Med,2023,21:708.
[38] HUMPHREYS BD.Mechanisms of renal fibrosis［J］.Annu Rev Physiol,2018,80:309-326.
[39] YADA K,ROBERTS LA,OGINOME N,et al.Effect of acacia polyphenol supplementation on exercise-induced oxidative stress in mice liver and skeletal muscle［J］.Antioxidants(Basel),2019,9(1):29.
[40] ZHANG Q,LI Q,ZHAO H,et al.Neurodegenerative disease and antioxidant biomarkers:A bidirectional Mendelian randomization study［J］.Front Neurol,2023,14:1158366.
[41] KAUSHAL GP,CHANDRASHEKAR K,JUNCOS LA.Molecular interactions between reactive oxygen species and autophagy in kidney disease［J］.Int J Mol Sci,2019,20(15):3791.
[42] MAHMOUD MOUSTAFA E,RASHED ER,RASHED RR,et al.Piceatannol promotes hepatic and renal AMPK/SIRT1/PGC-1α mitochondrial pathway in rats exposed to reserpine or gamma-radiation［J］.Int J Immunopathol Pharmacol,2021,35:20587384211016194.
[43] EL BAKARY NM,ABDEL-RAFEI MK,MAAROUF RE,et al.Trans-resveratrol alleviates hepatic and renal injury in γ-irradiated rats［J］.Hum Exp Toxicol,2022,41:9603271221142817.
[44] NIU S,ZHANG Y.Applications and therapeutic mechanisms of action of mesenchymal stem cells in radiation-induced lung injury［J］.Stem Cell Res Ther,2021,12(1):212.
[45] ZHOU Y,LIU J,LI X,et al.JAC4 protects from X-ray radiation-induced intestinal injury by JWA-mediated anti-oxidation/inflammation signaling［J］.Antioxidants(Basel),2022,11(6):1067.
[46] SHENG X,ZHOU Y,WANG H,et al.Establishment and characterization of a radiation-induced dermatitis rat model［J］.J Cell Mol Med,2019,23(5):3178-3189.
[47] KADATANE SP,SATARIANO M,MASSEY M,et al.The role of inflammation in CKD［J］.Cells,2023,12(12):1581.
[48] UNTHANK JL,ORTIZ M,TRIVEDI H,et al.Cardiac and renal delayed effects of acute radiation exposure:Organ differences in vasculopathy,inflammation,senescence and oxidative balance［J］.Radiat Res,2019,191(5):383-397.
[49] COHEN EP,FARESE AM,PARKER GA,et al.Lack of cellular inflammation in a non-human primate model of radiation nephropathy［J］.Health Phys,2020,119(5):588-593.
[50] JIAO Y,CAO F,LIU H.Radiation-induced cell death and its mechanisms［J］.Health Phys,2022,123(5):376-386.
[51] HYE KHAN MA,FISH B,WAHL G,et al.Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy［J］.Clin Sci(Lond),2016,130(8):587-599.
[52] BERTHELOOT D,LATZ E,FRANKLIN BS.Necroptosis,pyroptosis and apoptosis:an intricate game of cell death［J］.Cell Mol Immunol,2021,18(5):1106-1121.
[53] DING Y,LIU S,ZHANG M,et al.Suppression of NLRP3 inflammasome activation by astragaloside IV via promotion of mitophagy to ameliorate radiation-induced renal injury in mice［J］.Transl Androl Urol,2024,13(1):25-41.
[54] KIRSCHNER K,RATTANAVIROTKUL N,QUINCE MF,et al.Functional heterogeneity in senescence［J］.Biochem Soc Trans,2020,48(3):765-773.
[55] SCHWAB N,JU Y,HAZRATI LN.Early onset senescence and cognitive impairment in a murine model of repeated mTBI［J］.Acta Neuropathol Commun,2021,9(1):82.
[56] SALMINEN A,KAUPPINEN A,KAARNIRANTA K.Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype(SASP)［J］.Cellular Signalling,2012,24(4):835-845.
[57] MYLONAS KJ,O' SULLIVAN ED,HUMPHRIES D,et al.Cellular senescence inhibits renal regeneration after injury in mice,with senolytic treatment promoting repair［J］.Sci Transl Med,2021,13(594):eabb0203.
[58] SATYAMITRA MM,DICARLO AL,TALIAFERRO L.Understanding the pathophysiology and challenges of development of medical countermeasures for radiation-induced vascular/endothelial cell injuries:Report of a NIAID workshop,august 20,2015［J］.Radiat Res,2016,186(2):99-111.
[59] MOSTAGHIMI S,MEHRVAR S,FOOMANI FH,et al.Vascular regression in the kidney:changes in 3D vessel structure with time post-irradiation［J］.Biomed Opt Express,2022,13(8):4338-4352.
[60] STRAUB JM,NEW J,HAMILTON CD,et al.Radiation-induced fibrosis:mechanisms and implications for therapy［J］.J Cancer Res Clin Oncol,2015,141(11):1985-1994.
[61] WANG B,WEI J,MENG L,et al.Advances in pathogenic mechanisms and management of radiation-induced fibrosis［J］.Biomed Pharmacother,2020,121:109560.
[62] ZHUANG Q,MA R,YIN Y,et al.Mesenchymal stem cells in renal fibrosis:The flame of cytotherapy［J］.Stem Cells Int,2019,2019:8387350.
[63] SON B,KIM TR,PARK JH,et al.SAMiRNA targeting amphiregulin alleviate total-body-irradiation-induced renal fibrosis［J］.Radiat Res,2022,197(5):471-479.
[64] AHMAD A,SHI J,ANSARI S,et al.Radiation nephropathy:Mechanisms of injury and recovery in a murine model［J］.Radiother Oncol,2023,187:109813.
[65] MIRABITO COLAFELLA KM,BOVE DM,DANSER AHJ.The renin-angiotensin-aldosterone system and its therapeutic targets［J］.Exp Eye Res,2019,186:107680.
[66] AMES MK,ATKINS CE,PITT B.The renin-angiotensin-aldosterone system and its suppression［J］.J Vet Intern Med,2019,33(2):363-382.
[67] HSU CN,TAIN YL.Targeting the renin-angiotensin-aldosterone system to prevent hypertension and kidney disease of developmental origins［J］.Int J Mol Sci,2021,22(5):2298.
[68] NISHIYAMA A,KOBORI H.Independent regulation of renin-angiotensin-aldosterone system in the kidney［J］.Clin Exp Nephrol,2018,22(6):1231-1239.
[69] SAHEBNASAGH A,SAGHAFI F,AZIMI S,et al.Pharmacological interventions for the prevention and treatment of kidney injury induced by radiotherapy:Molecular mechanisms and clinical perspectives［J］.Curr Mol Pharmacol,2022,15(4):607-619.
[70] MEDHORA M,PHADNIS P,NARAYANAN J,et al.Radiation increases bioavailability of lisinopril,a mitigator of radiation-induced toxicities［J］.Front Pharmacol,2021,12:646076.
[71] MEHRVAR S,LA COUR MF,MEDHORA M,et al.Optical metabolic imaging for assessment of radiation-induced injury to rat kidney and mitigation by lisinopril［J］.Ann Biomed Eng,2019,47(7):1564-1574.
[72] JOKAR S,MARQUES IA,KHAZAEI S,et al.The footprint of exosomes in the radiation-induced bystander effects［J］.Bioengineering(Basel),2022,9(6):243.
[73] MONTEIRO LJ,PEＮAILILLO R,SNCHEZ M,et al.The role of long non-coding RNAs in trophoblast regulation in preeclampsia and intrauterine growth restriction［J］.Genes(Basel),2021,12(7):970.
[74] YANG Z,ZHONG W,YANG L,et al.The emerging role of exosomes in radiotherapy［J］.Cell Commun Signal,2022,20(1):171.
[75] LI H,JIANG M,ZHAO SY,et al.Exosomes are involved in total body irradiation-induced intestinal injury in mice［J］.Acta Pharmacol Sin,2021,42(7):1111-1123.
[76] LI H,ZHAO S,JIANG M,et al.Biomodified extracellular vesicles remodel the intestinal microenvironment to overcome radiation enteritis［J］.ACS Nano,2023,17(14):14079-14098.

Memo

Memo:
-
Last Update: 2024-09-30