|Table of Contents|

Expression of SPP1 and PD-L1 in endometrial carcinoma tissues and its prognostic value

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 21
Page:
4121-4126
Research Field:
Publishing date:

Info

Title:
Expression of SPP1 and PD-L1 in endometrial carcinoma tissues and its prognostic value
Author(s):
HU Shuai1; WU Xia1; JIN Yunan1; FAN Yuyu1; SUO Yuping2
1.The Fifth Clinical Medical College of Shanxi Medical University,Shanxi Taiyuan 030012,China;2.Department of Obstetrics and Gynecology,Shanxi Provincial People's Hospital,Shanxi Taiyuan 030012,China.
Keywords:
SPP1; PD-L1; endometrial carcinoma; prognosis
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2024.21.019
Abstract:
Objective:To analyze the expression levels of secreted phosphoprotein 1(SPP1) and programmed cell death-ligand 1(PD-L1) in endometrial carcinoma(EC) and their relationship with prognosis.Methods:The expression of SPP1 and PD-L1 in 84 EC tissues and 61 normal endometrial tissues was analyzed by immunohistochemical method,and the relationship between the expression of SPP1 and PD-L1 and clinicopathological features and prognosis was analyzed.The expression of SPP1 and PD-L1 mRNA in EC tissues in the database of The Cancer Genome Atlas(TCGA) and its relationship with prognosis were analyzed by UALCAN(https://ualcan.path.uab.edu/).Results:The positive expression rate of SPP1 in EC tissue was higher than that in normal endometrium(71.43% vs 36.07%,P=0.001),and the positive expression rate of PD-L1 was lower than that in normal endometrium(25.00% vs 42.62%,P=0.025).In EC tissues,the positive expression rate of SPP1 was correlated with histological grade(P<0.05),the positive expression rate of PD-L1 was correlated with lymph node metastasis(P<0.05),and SPP1 was positively correlated with PD-L1 expression(column connection number r=0.237,P=0.026).In EC tissue,there was no difference in the overall survival of patients with different SPP1 and PD-L1 expressions(all P>0.05).Bioinformatics analysis in TCGA database showed that the expression level of SPP1 mRNA in EC was significantly higher than that in normal endometrium(P<0.01),and there was no significant difference in the expression level of PD-L1 mRNA between EC and normal endometrium(P=0.057).The expression levels of SPP1 mRNA and PD-L1 mRNA in EC tissues were positively correlated(r=0.350,P<0.05).There was no difference in the overall survival of patients with different levels of SPP1 and PD-L1 expression(all P>0.05).Conclusion:The expression of SPP1 in EC tissue is positively correlated with PD-L1,which may be involved in the regulation of EC immune microenvironment.SPP1 and PD-L1 are not independent prognostic factors of EC.

References:

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Last Update: 2024-09-30