［1］ ZHAO BS,ROUNDTREE IA,HE C.Post-transcriptional gene regulation by mRNA modifications［J］.Nat Rev Mol Cell Biol,2017,18(1):31-42.
［2］ BOKAR JA,RATH-SHAMBAUGH ME,LUDWICZAK R,et al.Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei.Internal mRNA methylation requires a multisubunit complex［J］.J Biol Chem,1994,269(26):17697-17704.
［3］ BOKAR JA,SHAMBAUGH ME,POLAYES D,et al.Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase［J］.RNA,1997,3(11):1233-1247.
［4］ HUANG J,DONG X,GONG Z,et al.Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase［J］.Protein Cell,2019,10(4):272-284.
［5］ DOXTADER KA,WANG P,SCARBOROUGH AM,et al.Structural basis for regulation of METTL16,an S-adenosylmethionine homeostasis factor［J］.Mol Cell,2018,71(6):1001-1011.e1004.
［6］ LIU J,YUE Y,HAN D,et al.A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation［J］.Nat Chem Biol,2014,10(2):93-95.
［7］ BARTEL DP.Metazoan microRNAs［J］.Cell,2018,173(1):20-51.
［8］ HAN J,WANG JZ,YANG X,et al.METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner［J］.Mol Cancer,2019,18(1):110.
［9］ PENG W,LI J,CHEN R,et al.Upregulated METTL3 promotes metastasis of colorectal cancer via miR-1246/SPRED2/MAPK signaling pathway［J］.J Exp Clin Cancer Res,2019,38(1):393.
［10］ WANG H,DENG Q,LYU Z,et al.N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1［J］.Mol Cancer,2019,18(1):181.
［11］ CHOE J,LIN S,ZHANG W,et al.mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis［J］.Nature,2018,561(7724):556-560.
［12］ WANG Q,CHEN C,XU X,et al.APAF1-binding long noncoding RNA promotes tumor growth and multidrug resistance in gastric cancer by blocking apoptosome assembly［J］.Adv Sci,2022,9(28):e2201889.
［13］ LI H,ZHONG Y,CAO G,et al.METTL3 promotes cell cycle progression via m(6)A/YTHDF1-dependent regulation of CDC25B translation［J］.Int J Biol Sci,2022,18(8):3223-3236.
［14］ LIN S,CHOE J,DU P,et al.The m(6)A methyltransferase METTL3 promotes translation in human cancer cells［J］.Mol Cell,2016,62(3):335-345.
［15］ JAGGA B,EDWARDS M,PAGIN M,et al.Structural basis for nuclear import selectivity of pioneer transcription factor SOX2［J］.Nat Commun,2021,12(1):28.
［16］ VISVANATHAN A,PATIL V,ARORA A,et al.Essential role of METTL3-mediated m(6)A modification in glioma stem-like cells maintenance and radioresistance［J］.Oncogene,2018,37(4):522-533.
［17］ LI T,HU PS,ZUO Z,et al.METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma［J］.Mol Cancer,2019,18(1):112.
［18］ WANG J,YU H,DONG W,et al.N6-methyladenosine-mediated up-regulation of FZD10 regulates liver cancer stem cells' properties and lenvatinib resistance through WNT/β-catenin and hippo signaling pathways［J］.Gastroenterology,2023,164(6):990-1005.
［19］ WANG H,HU X,HUANG M,et al.METTL3-mediated mRNA m(6)A methylation promotes dendritic cell activation［J］.Nat Commun,2019,10(1):1898.
［20］ XIE JW,HUANG XB,CHEN QY,et al.m(6)A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling［J］.Mol Cancer,2020,19(1):114.
［21］ LIN S,LIU J,JIANG W,et al.METTL3 promotes the proliferation and mobility of gastric cancer cells［J］.Open Med (Wars),2019,14:25-31.
［22］ YUE B,SONG C,YANG L,et al.METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer［J］.Mol Cancer,2019,18(1):142.
［23］ LIU T,YANG S,SUI J,et al.Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer［J］.J Cell Physiol,2020,235(1):548-562.
［24］ WANG Q,CHEN C,DING Q,et al.METTL3-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance［J］.Gut,2020,69(7):1193-1205.
［25］ WANG N,HUO X,ZHANG B,et al.METTL3-mediated ADAMTS9 suppression facilitates angiogenesis and carcinogenesis in gastric cancer［J］.Front Oncol,2022,12:861807.
［26］ XU W,LAI Y,PAN Y,et al.m6A RNA methylation-mediated NDUFA4 promotes cell proliferation and metabolism in gastric cancer［J］.Cell Death Dis,2022,13(8):715.
［27］ HU H,KONG Q,HUANG XX,et al.Long non-coding RNA BLACAT2 promotes gastric cancer progression via the miR-193b-5p/METTL3 pathway［J］.J Cancer,2021,12(11):3209-3221.
［28］ ZHANG JY,DU Y,GONG LP,et al.EBV-circRPMS1 promotes the progression of EBV-associated gastric carcinoma via Sam68-dependent activation of METTL3［J］.Cancer Lett,2022,535:215646.
［29］ LI H,WANG C,LAN L,et al.METTL3 promotes oxaliplatin resistance of gastric cancer CD133+stem cells by promoting PARP1 mRNA stability［J］.Cell Mol Life Sci,2022,79(3):135.
［30］ SUN Y,LI S,YU W,et al.N(6)-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer［J］.Cell Death Dis,2020,11(10):836.
［31］ LI TZ,HAO DD.Research progress of insights into the molecular mechanisms of m6A modification of ferroptosis in cancer［J］.Modern Oncology,2023,31(24):4640-4645.
［32］ CHEN MM,XU K.The research progress on m6A RNA methylation in cancer［J］.Modern Oncology,2023,31(07):1352-1358.
［33］ YANKOVA E,BLACKABY W,ALBERTELLA M,et al.Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia［J］.Nature,2021,593(7860):597-601.
［34］ WANG JN,WANG F,KE J,et al.Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms［J］.Sci Transl Med,2022,14(640):eabk2709.