|Table of Contents|

Effects of esketamine on recovery quality,analgesia and emotional state in thyroid cancer surgery patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 20
Page:
3921-3925
Research Field:
Publishing date:

Info

Title:
Effects of esketamine on recovery quality,analgesia and emotional state in thyroid cancer surgery patients
Author(s):
TIAN Jieli1; HE Wensheng1; WANG Qing1; TAO Wenhui2
1.Anesthesiology Department，Anhui Medical University Affiliated Hefei Hospital，Anhui Hefei 230011,China;2.Anesthesiology Department,the Second Affiliated Hospital of Anhui Medical University,Anhui Hefei 230011,China.
Keywords:
thyroid cancer; esketamine; recovery quality; emotional state
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2024.20.019
Abstract:
Objective:To investigate the effects of esketamine on recovery quality,analgesia and emotional state in thyroid cancer surgery patients.Methods:106 patients who underwent thyroidectomy under general anesthesia in our hospital from June 2021 to June 2023 were selected and randomly divided into control group and observation group.The observation group was given esketamine 0.5 mg/kg within 10 minutes before anesthesia induction,while the control group was given the same dose of normal saline by the same method.Anesthesia related indexes were observed.The postoperative pain degree ［pain numerical scale (NRS)］,quality of anesthesia recovery ［alertness assessment/sedation scale (OAA/S)］ and anxiety and depression mood ［hospital anxiety and depression scale (HADS)］ were assessed,and the occurrence of adverse reactions at 24 h after surgery was recorded.Results:There was no significant difference in anesthesia time,extubation time,recovery time of spontaneous respiration and awakening time of eyes between the two groups (P＞0.05).Compared with control group,the mean arterial pressure (MAP) and heart rate (HR) after extubation in observation group were lower (P＜0.05).The difference of NRS score between the two groups was statistically significant (P＜0.05),the NRS score of the two groups did not change with time (P＞0.05),and there was an interaction effect between the groups and time (P＜0.05).There was no significant difference in NRS scores at 30 min after extubation between the two groups (P＞0.05).Compared with the control group,NRS scores in the observation group were lower at 6 h,12 h and 24 h after extubation (P＜0.05).There was no significant difference in OAA/S scores between the two groups immediately after surgery and at 30 min after surgery (P＞0.05).At 1 day before surgery,there was no significant difference in HADS-A and HADS-D scores between the two groups (P＞0.05).Compared with 1 day before surgery,there was no significant difference in the HADS-A and HADS-D scores at 3 days after surgery in the observation group (P＞0.05),while the two scores in the control group were increased (P＜0.05).At 3 days after operation,the HADS-A and HADS-D scores in the observation group were lower than those in the control group,and the difference was statistically significant (P＜0.05).Compared with the control group,the incidence of cough in the observation group was less (P＜0.05).Conclusion:Esketamine used in radical resection of thyroid cancer can reduce postoperative pain,improve the quality of recovery,and improve anxiety and depression.

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Memo

Memo:
安徽省高校科研项目(自然科学类)（编号：2023AH053181）
Last Update: 1900-01-01