|Table of Contents|

Research progress on the role of Fra-1 in cancer and related signal pathways

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 19
Page:
3813-3817
Research Field:
Publishing date:

Info

Title:
Research progress on the role of Fra-1 in cancer and related signal pathways
Author(s):
LU Yue; ZENG Jingya; LIU Kaiyue; CHENG Yangyang; SUN Yihua
Harbin Medical University Affiliated Tumor Hospital,Heilongjiang Harbin 150000，China.
Keywords:
Fra-1; cancer; transcription factor; signaling pathway; nanomaterial
PACS:
R73
DOI:
10.3969/j.issn.1672-4992.2024.19.033
Abstract:
The transcription factor Fra-1,which is expressed by the FOSL1 gene,is an essential component of the activator protein 1(AP-1) dimer complex transcription factor family and is involved in the metastasis and development of human malignancies.Most malignancies have increased Fra-1 expression,which is triggered by many signaling pathways.Fra-1,a crucial transcription factor,has the ability to control the production of numerous proteins,including those involved in the epithelial-mesenchymal transition(EMT),matrix metalloproteinases-1(MMP-1),MMP-9,etc.This article will concentrate on the various functions of Fra-1 in various malignancies and the various signaling pathways involved.

References:

［1］QI J,LI M,WANG L,et al.National and subnational trends in cancer burden in China,2005-20:An analysis of national mortality surveillance data［J］.Lancet Public Health,2023,8(12) e943-e955.
［2］BASBOUS J,JARIEL-ENCONTRE I,GOMARD T,et al.Ubiquitin-independent-versus ubiquitin-dependent proteasomal degradation of the c-Fos and Fra-1 transcription factors:Is there a unique answer［J］.Biochimie,2008,90(2):296-305.
［3］CASALINO L,TALOTTA F,CIMMINO A,et al.The Fra-1/AP-1 oncoprotein:From the "undruggable" transcription factor to therapeutic targeting［J］.Cancers(Basel),2022,14(6):1480.
［4］XU H,JIN X,YUAN Y,et al.Prognostic value from integrative analysis of transcription factors c-Jun and Fra-1 in oral squamous cell carcinoma:A multicenter cohort study［J］.Sci Rep,2017,7(1):7522.
［5］TOYOZUMI T,HOSHINO I,TAKAHASHI M,et al.Fra-1 regulates the expression of HMGA1,which is associated with a poor prognosis in human esophageal squamous cell carcinoma［J］.Ann Surg Oncol,2017,24(11):3446-3455.
［6］WANG C,LI Z,SHAO F,et al.High expression of collagen triple helix repeat containing 1(CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation［J］.J Exp Clin Cancer Res,2017,36(1):84.
［7］HE J,ZHU G,GAO L,et al.Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer［J］.Int J Oncol,2015,47(5):1725-1734.
［8］YANG Y,DONG K,SHAO S.The effect of Helicobacter pylori on the expression of FRA-1 in gastric epithelial cells and its mechanism［J］.Microb Pathog,2019,129:257-265.
［9］HE J,ZENG F,JIN XI,et al.YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells［J］.Oncol Res,2023,31(4):615-630.
［10］YUN SI,HONG HK,YEO SY,et al.Ubiquitin-specific protease 21 promotes colorectal cancer metastasis by acting as a Fra-1 deubiquitinase［J］.Cancers(Basel),2020,12(1):207.
［11］DUONG HQ,NEMAZANYY I,RAMBOW F,et al.The endosomal protein CEMIP links WNT signaling to MEK1-ERK1/2 activation in selumetinib-resistant intestinal organoids［J］.Cancer Res,2018,78(16):4533-4548.
［12］CUI HY,WEI W,QIAN MR,et al.PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression［J］.Cancer Commun(Lond),2022,42(8):750-767.
［13］ZHANG M,LIANG L,HE J,et al.Fra-1 inhibits cell growth and the Warburg effect in cervical cancer cells via STAT1 regulation of the p53 signaling pathway［J］.Front Cell Dev Biol,2020,8:579629.
［14］DOU Y,HUANG D,ZENG X,et al.All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer［J］.Biotechnol Lett,2020,42(6):1051-1060.
［15］XIAO S,ZHOU Y,YI W,et al.Fra-1 is downregulated in cervical cancer tissues and promotes cervical cancer cell apoptosis by p53 signaling pathway in vitro［J］.Int J Oncol,2015,46(4):1677-1684.
［16］WANG M,QIAO X,COOPER T,et al.HPV E7-mediated NCAPH ectopic expression regulates the carcinogenesis of cervical carcinoma via PI3K/AKT/SGK pathway［J］.Cell Death Dis,2020,11(12):1049.
［17］JAVELLANA M,ECKERT MA,HEIDE J,et al.Neoadjuvant chemotherapy induces genomic and transcriptomic changes in ovarian cancer［J］.Cancer Res,2022,82(1):169-176.
［18］WU J,SUN Y,ZHANG PY,et al.The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells［J］.Cell Death Dis,2016,7(9):e2384.
［19］KAVYA K,KUMAR MN,PATIL RH,et al.Differential expression of AP-1 transcription factors in human prostate LNCaP and PC-3 cells:Role of Fra-1 in transition to CRPC status［J］.Mol Cell Biochem,2017,433(1-2):13-26.
［20］WU J,JI A,WANG X,et al.MicroRNA-195-5p,a new regulator of Fra-1,suppresses the migration and invasion of prostate cancer cells［J］.J Transl Med,2015,13:289.
［21］CASALINO L,TALOTTA F,MATINO I,et al.FRA-1 as a regulator of EMT and metastasis in breast cancer［J］.Int J Mol Sci,2023,24(9):8307.
［22］LEE S,LEE A,LIM J,et al.Regulation of tumor-associated macrophage(TAM) differentiation by NDRG2 expression in breast cancer cells［J］.BMB Rep,2022,55(2):81-86.
［23］BELGUISE K,CHERRADI S,SARR A,et al.PKCθ-induced phosphorylations control the ability of Fra-1 to stimulate gene expression and cancer cell migration［J］.Cancer Lett,2017,385:97-107.
［24］SHU L,CHEN A,LI L,et al.NRG1 regulates Fra-1 transcription and metastasis of triple-negative breast cancer cells via the c-Myc ubiquitination as manipulated by ERK1/2-mediated Fbxw7 phosphorylation［J］.Oncogene,2022,41(6):907-919.
［25］CHEN X,ZHAO M,HUANG J,et al.MicroRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1［J］.J Cell Biochem,2018,119(6):4945-4956.
［26］KIM JE,KIM BG,JANG Y,et al.The stromal loss of miR-4516 promotes the FOSL1-dependent proliferation and malignancy of triple negative breast cancer［J］.Cancer Lett,2020,469:256-265.
［27］ZHONG G,CHEN X,FANG X,et al.Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the p53 signaling pathway［J］.Oncol Rep,2016,35(1):447-453.
［28］ZHAO W,YU D,ZHAI Y,et al.ALK inhibitors downregulate the expression of death receptor 4 in ALK-mutant lung cancer cells via facilitating Fra-1 and c-Jun degradation and subsequent AP-1 suppression［J］.Neoplasia,2023,42:100908.
［29］ZHAO Q,ZHANG K,LI Y,et al.OLFML2A is necessary for anti-triple negative breast cancer effect of selective activator protein-1 inhibitor T-5224［J］.Transl Oncol,2021,14(8):101100.
［30］XIA Y,DENG X,CAO M,et al.Nanodiamond-based layer-by-layer nanohybrids mediate targeted delivery of miR-34a for triple negative breast cancer therapy［J］.RSC Adv,2018,8(25):13789-13797.
［31］LIU R,MU LM,BAI J,et al.Development of double strand RNA mPEI nanoparticles and application in treating invasive breast cancer［J］.RSC Adv,2019,9(23):13186-13200.
［32］VALLEJO A,ERICE O,ENTRIALGO-CADIERNO R,et al.FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted［J］.J Hepatol,2021,75(2):363-376.
［33］LU D,CHEN S,TAN X,et al.Fra-1 promotes breast cancer chemosensitivity by driving cancer stem cells from dormancy［J］.Cancer Res,2012,72(14):3451-3456.

Memo

Memo:
黑龙江省自然科学基金项目（编号：LH2021H082）
Last Update: 2024-08-30