|Table of Contents|

Research progress on the relationship between cancer associated fibroblasts and chemotherapy resistance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 19
Page:
3779-3785
Research Field:
Publishing date:

Info

Title:
Research progress on the relationship between cancer associated fibroblasts and chemotherapy resistance
Author(s):
WANG XinmiaoCAO LuchangLI Jie
Department of Oncology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China.
Keywords:
cancer associated fibroblastschemotherapy resistanceresearch progress
PACS:
R73
DOI:
10.3969/j.issn.1672-4992.2024.19.027
Abstract:
Cancer associated fibroblasts(CAFs) are the most abundant stromal cells in the tumor microenvironment,with high heterogeneity and extensive sources.They are the communication hub between various cells in the tumor stroma and are closely related to chemotherapy resistance.Unlike previous studies that only focused on tumor cells themselves,this article focuses on stromal cell CAFs in the tumor microenvironment,and reviews their sources,heterogeneity,and mechanisms related to CAFs promoting chemotherapy resistance(releasing exosomes,regulating signaling pathways,regulating autophagy,promoting cancer cell stemnesis,and regulating cell aging).At the same time,it explores strategies for regulating CAFs to improve chemotherapy resistance,aiming to explore new strategies for targeting CAFs to respond to chemotherapy resistance and provide insights for clinical practice.

References:

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Memo

Memo:
National Natural Science Foundation of China(No.82074402,82305347);国家自然科学基金资助项目(编号:82074402,82305347);国家资助博士后研究人员计划(编号:GZC20233128);中央级公益性科研院所基本科研业务费专项资金资助项目(编号:ZZ16-XRZ-037)
Last Update: 2024-08-30