|Table of Contents|

The value of CT-based radiomics model in the evaluation of perineural or lympho-vascular invasion in rectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 19
Page:
3738-3743
Research Field:
Publishing date:

Info

Title:
The value of CT-based radiomics model in the evaluation of perineural or lympho-vascular invasion in rectal cancer
Author(s):
YU Jingzhou1; 2; LYU Xiaojing1; SUN Yalin1; REN Shuai1; WANG Zhongqiu1
1.Department of Radiology,Affiliated Hospital of Nanjing University of Chinese Medicine(Jiangsu Province Hospital of Chinese Medicine),Jiangsu Nanjing 210029,China;2.Department of Radiology,the Second Affiliated Hospital of Nanjing University of Chinese Medicine(Jiangsu Provincial Second Traditional Chinese Medicine Hospital),Jiangsu Nanjing 210017,China.
Keywords:
tomography; X-ray computer; rectal cancer; diagnosis; radiomics
PACS:
R735.3+7
DOI:
10.3969/j.issn.1672-4992.2024.19.019
Abstract:
Objective:To investigate the value of evaluating nerve or lympho-vascular invasion around rectal cancer based on CT radiomics model.Methods:The clinical and imaging data of 196 patients with colorectal cancer confirmed by pathology in our hospital from December 2017 to June 2021 were retrospectively analyzed.There were 107 cases without nerve and lympho-vascular invasion,and 89 cases with nerve or lympho-vascular invasion.All patients underwent preoperative total abdominal CT scan and enhanced scan.The stratified random sampling method divided patients into training group and test group by 8∶2 ratio (157 vs 39).A total of 113 radiomics features were extracted by PyRadiomics software based on preoperative CT images.Spearman correlation analysis and least absolute shrinkage and selection operator (LASSO) were used for feature selection and model building.Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic potential of the CT-based radiomics model in the prediction of nerve or lympho-vascular invasion around rectal cancer.Results:After feature selection,13 radiomics features in plain scan and 15 in venous phase were used to construct a model for evaluating the presence or absence of nerve or lympho-vascular invasion around rectal cancer.In the training group,the area under curve (AUC) of the prediction model was 0.91 (95% CI:0.86~0.96) with 91.8% sensitivity,76.6% specificity,and 83.3% accuracy.In the test group,the AUC was 0.91 (95%CI:0.82~0.97),with 85.7% sensitivity,80.0% specificity,and 82.7% accuracy.Conclusion:The CT-based radiomics model could be used to evaluate the presence of nerve and lympho-vascular invasion around rectal cancer,which showed a high diagnostic performance.

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Last Update: 2024-08-30