|Table of Contents|

The structure and function of TRIM28 protein and its research progress in tumor

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 18
Page:
3589-3596
Research Field:
Publishing date:

Info

Title:
The structure and function of TRIM28 protein and its research progress in tumor
Author(s):
HOU Xueyang12SONG Dandan12XU Xiaozhen12XIAO Shuai12ZHOU Cefan12TANG Jingfeng12
1.Department of Biomedicine/Institute of Biomedicine,College of Bioengineering and Food Science,Hubei University of Technology,Hubei Wuhan 430068,China;2.National "111" Research Center for Cell Regulation and Molecular Drugs,Hubei University of Technology,Hubei Wuhan 430068,China.
Keywords:
TRIM28E3 ubiquitin ligasefunctiontumour
PACS:
R730.231
DOI:
10.3969/j.issn.1672-4992.2024.18.030
Abstract:
Tripartite motif 28 (TRIM28) is an E3 ubiquitin ligase belonging to the tripartite motif-containing (TRIM) family.It has a typical RBCC (RING,B-box,Coiled-coil) domain and a variable C-terminal domain.TRIM28 is distributed in the nucleus and cytoplasm.In addition to E3 ubiquitin ligase activity,it also has SUMO E3 ubiquitin ligase activity and can be used as a transcription factor to regulate the transcription of target genes.TRIM28 plays an important role in cell proliferation and differentiation,and is also involved in cancer-related signaling pathways,thereby promoting the proliferation,invasion,and migration of many common cancer cells such as non-small cell lung cancer,breast cancer,and gastric cancer,and inhibiting the occurrence of apoptosis.In this paper,the protein structure,biological function,signaling pathway of TRIM28,and its role in tumorigenesis and development are reviewed.

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Memo

Memo:
National Natural Science Foundation of China(No.82273970);国家自然科学基金资助项目(编号:82273970);湖北工业大学人才引进项目(编号:XJ2022003901)
Last Update: 1900-01-01