|Table of Contents|

The predictive value of preoperative neutrophil to lymphocyte ratio for the prognosis of testicular germ cell tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 18
Page:
3519-3525
Research Field:
Publishing date:

Info

Title:
The predictive value of preoperative neutrophil to lymphocyte ratio for the prognosis of testicular germ cell tumors
Author(s):
LI Zongyang1; ZHANG Zhilei2; ZHU Tao2; WU Yushu1; GUO Zhifan1; ZANG Yunjiang2
1.School of Clinical Medicine，Shandong Second Medical University，Shandong Weifang 261041，China；2.Department of Urology，Weifang People's Hospital，Shandong Weifang 261041，China.
Keywords:
testicular germ cell tumors; neutrophil to lymphocyte ratio; cancer specific survival; progression-free survival
PACS:
R737.21
DOI:
10.3969/j.issn.1672-4992.2024.18.019
Abstract:
Objective:To investigate the predictive value of preoperative neutrophil to lymphocyte ratio (NLR) for the prognosis of patients with testicular germ cell tumors (TGCT).Method:Collect clinical and follow-up data of TGCT patients who underwent testicular radical surgery at Weifang People's Hospital from January 2016 to October 2023.Determine the optimal cut-off value of NLR through receiver operating characteristic curve (ROC),and plot the survival curve using Kaplan-Meier analysis to compare the differences in cancer specific survival (CSS) and progression-free survival (PFS) between high and low NLR groups.Cox proportional hazards model was used to screen independent risk factors affecting CSS and PFS.Results:33 patients were included,including 21 cases (63.6%) of seminomatous germ cell tumor(SGCT) and 12 cases (36.4%) of non-seminomatous germ cell tumor(NSGCT).The Kaplan-Meier analysis results indicated that high NLR indicated poorer CSS (P＜0.001) and PFS (P＜0.001).Cox regression results showed that high NLR (HR=18.225,95%CI:1.806~183.859,P=0.014) was an independent risk factor for CSS.High NLR (HR=11.371,95%CI:1.751~73.847,P=0.011) was also an independent risk factor for PFS.Conclusion:High preoperative NLR is an independent risk factor affecting the prognosis of TGCT patients,and the higher the NLR,the worse the CSS and PFS of patients.

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