|Table of Contents|

Application effect of three-dimensional reconstruction technique in radical resection of colorectal cancer and its influence on immune function,gastrointestinal function and postoperative outcome

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 18
Page:
3488-3494
Research Field:
Publishing date:

Info

Title:
Application effect of three-dimensional reconstruction technique in radical resection of colorectal cancer and its influence on immune function,gastrointestinal function and postoperative outcome
Author(s):
ZHAO Bin; LIU Jipan; LIU Yabin
The Second Department of General Surgery,Hengshui People's Hospital,Hebei Hengshui 053000,China.
Keywords:
colorectal cancer; radical resection of colorectal cancer; 3D reconstruction technology; multi-row spiral CT enhanced images; postoperative outcome; gastrointestinal function; immune T lymphocytes; complication
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2024.18.014
Abstract:
Objective:To investigate the application effect of three-dimensional reconstruction technology in radical resection of colorectal cancer (CRC) and its influence on immune function,gastrointestinal function and postoperative outcome.Methods:A total of 83 CRC patients admitted to our hospital from January 2020 to April 2023 were selected,all of whom underwent laparoscopic radical CRC surgery.The patients were randomly divided into two groups.The preoperative planning of 41 patients in the control group was performed according to enhanced multi-slice spiral CT images,and the preoperative planning of 42 patients in the observation group was performed according to three-dimensional vascular model of multi-slice spiral CT.Perioperative indexes,postoperative outcomes,gastrointestinal function,immune T lymphocytes (CD3+,CD4+,CD4+/CD8+) and complications of the two groups were observed.Results:The operation time,first postoperative exhaust,semi-liquid feeding,first defecation and postoperative hospitalization time in the observation group were shorter than those in the control group,the amount of intraoperative blood loss and 24 h postoperative drainage volume were lower than those in the control group (P＜0.05).The levels of motilin,gastrin and cholecystokinin in observation group were higher than those in control group at 3 and 7 days after operation (P＜0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group at 3 and 7 days after operation (P＜0.05).The incidence of complications in the observation group was significantly lower than that in the control group (P＜0.05).Conclusion:Three-dimensional reconstruction technology assisted radical operation for CRC can optimize the operation,reduce the damage of gastrointestinal function and immune function,promote the recovery of the disease,and improve the safety.

References:

［1］ CAO W,CHEN HD,YU YW,et al.Changing profiles of cancer burden worldwide and in China:a secondary analysis of the global cancer statistics 2020［J］.Chin Med J (Engl),2021,134(7):783-791.
［2］ DAVIES J,CHEW C,BROMHAM N,et al.NICE 2020 guideline for the management of colorectal cancer［J］.Lancet Oncol,2022,23(6):e247.
［3］ HASSAN C,WYSOCKI PT,FUCCIO L,et al.Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer:European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline［J］.Endoscopy,2019,51(3):266-277.
［4］ 中华医学会外科学分会结直肠外科学组.吲哚菁绿近红外光成像在腹腔镜结直肠癌手术中应用中国专家共识(2021版)［J］.中国实用外科杂志,2021,41(10):1098-1103,1110. Colorectal Surgery Group,Surgical Society of Chinese Medical Association.Indocyanine green near-infrared imaging in laparoscopic colorectal cancer surgery:Chinese expert Consensus (2021 edition)［J］.Chinese Journal of Practical Surgery,2021,41(10):1098-1103,1110.
［5］ CECCARELI G,COSTA G,FERRARO V,et al.Robotic or three-dimensional (3D) laparoscopy for right colectomy with complete mesocolic excision (CME) and intracorporeal anastomosis.A propensity score-matching study comparison［J］.Surg Endosc,2021,35(5):2039-2048.
［6］ 毛伟鉴,杨华.多层螺旋CT血管造影三维重建在腹腔镜结直肠癌根治术中的临床指导价值［J］.成都医学院学报,2021,16(2):180-183. MAO Weijian,YANG Hua.The clinical guidance value of three-dimensional reconstruction using multi-slice spiral CT angiography in laparoscopic radical resection of colorectal cancer ［J］.Journal of Chengdu Medical College,2021,16(2):180-183.
［7］ TO G,HAWKE JA,LARKINS K,et al.A systematic review of the application of 3D-printed models to colorectal surgical training［J］.Tech Coloproctol,2023,27(4):257-270.
［8］ SHRESTHA B,DUNN L.The declaration of helsinki on medical research involving human subjects:A review of seventh revision［J］.J Nepal Health Res Counc,2020,17(4):548-552.
［9］ 国家卫生计生委医政医管局,中华医学会肿瘤学分会.中国结直肠癌诊疗规范(2017年版)［J］.中华胃肠外科杂志,2018,21(1):92-106. The Medical Administration Bureau of the National Health and Family Planning Commission,and the Oncology Branch of the Chinese Medical Association.Chinese diagnosis and treatment guidelines for colorectal cancer (2017 edition) ［J］.Chinese Journal of Gastrointestinal Surgery,2018,21(1):92-106.
［10］ MAHMOUD NN.Colorectal cancer:Preoperative evaluation and staging［J］.Surg Oncol Clin N Am,2022,31(2):127-141.
［11］ SAWAIED M,BERGER Y,MAHAMID A,et al.Laparoscopic versus open simultaneous resection of primary colorectal cancer and associated liver metastases:A comparative retrospective study［J］.Surg Laparosc Endosc Percutan Tech,2021,32(1):73-78.
［12］ CHEN Y,BIAN L,ZHOU H,et al.Usefulness of three-dimensional printing of superior mesenteric vessels in right hemicolon cancer surgery［J］.Sci Rep,2020,10(1):11660.
［13］ 沈海玉.基于CTA和血管三维重建技术的结直肠系膜血管的解剖学观察及临床应用研究/生物信息学分析APOC1在结直肠癌肝转移的差异表达和预后价值的研究［D］.北京:北京协和医学院,2021. SHEN Haiyu.Anatomical observation and clinical application of mesocolon vessels based on CTA and three-dimensional vascular reconstruction technology/Bioinformatics analysis of differential expression and prognostic value of APOC1 in liver metastases of colorectal cancer ［D］.Beijing:Peking Union Medical College,2021.
［14］ WILLARD CD,KJAESTAD E,STIMEC BV,et al.Preoperative anatomical road mapping reduces variability of operating time,estimated blood loss,and lymph node yield in right colectomy with extended D3 mesenterectomy for cancer［J］.Int J Colorectal Dis,2019,34(1):151-160.
［15］ 陈建新,沈海平,袁燕文,等.三维可视化技术在腹腔镜结直肠癌D3根治术中应用价值［J］.实用医学杂志,2022,38(12):1533-1540. CHEN Jianxin,SHEN Haiping,YUAN Yanwen,et al.Application value of three-dimensional visualization technique in laparoscopic D3 radical resection of colorectal cancer ［J］.Journal of Practical Medicine,2022,38(12):1533-1540.
［16］ FABULAS F,PAISANT P,DINOMAIS M,et al.Pre-habilitation before colorectal cancer surgery could improve postoperative gastrointestinal function recovery:a case-matched study［J］.Langenbecks Arch Surg,2022,407(4):1595-1603.
［17］ 唐小兵,张超,周涛,等.不同CO2压力对腹腔镜直肠癌根治术患者术中应激反应及胃肠功能的影响［J］.局解手术学杂志,2020,29(04):308-312. TANG Xiaobing,ZHANG Chao,ZHOU Tao,et al.Effects of different CO2 pressure on stress response and gastrointestinal function in patients undergoing laparoscopic radical resection for rectal cancer ［J］.Journal of Local Surgery,2020,29(04):308-312.
［18］ 张金强,李文斌.腹腔镜直肠癌根治术中保留左结肠动脉对直肠癌患者胃肠功能、免疫系统及远期预后的影响［J］.贵州医药,2023,47(5):705-707. ZHANG Jinqiang,LI Wenbin.Effects of left colonic artery preservation on gastrointestinal function,immune system and long-term prognosis of patients with rectal cancer during laparoscopic radical resection of rectal cancer ［J］.Guizhou Medicine,2023,47(5):705-707.
［19］ NIE J,SU X,WEI L,et al.Early enteral nutrition support for colon carcinoma patients can improve immune function and promote physical recovery［J］.Am J Transl Res,2021,13(12):14102-14108.
［20］ VERDON DJ,MULAZZANI M,JENKINS MR.Cellular and molecular mechanisms of CD8+T cell differentiation,dysfunction and exhaustion［J］.Int J Mol Sci,2020,21(19):7357.
［21］ OSMAN A,YAN B,LI Y,et al.TCF-1 controls Treg cell functions that regulate inflammation,CD8+ T cell cytotoxicity and severity of colon cancer［J］.Nat Immunol,2021,22(9):1152-1162.

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河北省2022年度医学科学研究课题计划项目(编号：20221233)
Last Update: 1900-01-01