|Table of Contents|

Analysis of the correlation between the infiltrating density of tumor-associated neutrophils and PD-L1 expression in triple-negative breast cancer and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 18
Page:
3468-3474
Research Field:
Publishing date:

Info

Title:
Analysis of the correlation between the infiltrating density of tumor-associated neutrophils and PD-L1 expression in triple-negative breast cancer and its clinical significance
Author(s):
YANG Liu; GUI Xingxing; CHEN Yuexia; XIA Yun; ZHOU Guofeng; QU Wei
Nanchang People's Hospital,Jiangxi Nanchang 330025,China.
Keywords:
tumor-associated neutrophilsd(TANs); PD-L1; triple-negative breast cancer(TNBC); tumor microenvironment(TME); progression free survival(PFS)
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2024.18.011
Abstract:
Objective:The aim of this study was to analyze the correlation between the infiltrating density of tumor-associated neutrophils (TANs) and the expression of programmed death ligand-1 (PD-L1) in triple-negative breast cancer(TNBC),and its clinical significance.Methods:Tumor tissue specimens of 141 patients with triple-negative breast cancer in our hospital were selected.The antibody CD66b was used as the marker of TANs.The infiltrating density of TANs and the expression of PD-L1 were detected by immunohistochemistry in TNBC cancer tissues.Pearson product moment correlation and Spearman rank correlation were used to analyze the correlation between TANs infiltration,PD-L1 expression and clinicopathological characteristics,as well as the correlation between TANs infiltration density and PD-L1 positive expression in TNBC cancer tissues.The survival analysis of TNBC patients was analyzed by Kaplan-Meier curve.Results:Higher infiltrating density of TANs was positively correlated with higher Ki67 proliferation index,higher histological grade and lymph node metastasis (P＜0.05).PD-L1 expression was positively correlated with higher Ki67 proliferation index and higher histological grade (P＜0.05).The density of TANs was positively correlated with the positive expression of PD-L1 in TNBC tissues (P＜0.05).The density of TANs and the expression of PD-L1 were negatively correlated with progression free survival (PFS) in TNBC patients（P＜0.05）.Conclusion:The infiltrative density of TANs and expression of PD-L1 in TNBC tissues are closely related to a number of clinicopathological features and poor prognosis.These results suggest that TANs and PD-L1 can be used as important indicators for the prognosis evaluation of TNBC,and provide research basis for exploring potential targets for TNBC immunotherapy.

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