|Table of Contents|

Research progress of single cell sequencing in cervical cancer and precancerous lesions

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 17
Page:
3372-3378
Research Field:
Publishing date:

Info

Title:
Research progress of single cell sequencing in cervical cancer and precancerous lesions
Author(s):
AI Wenxia1; SHAO Zhuoyan1; QI Ding1; MEN Hao1; LIANG Mingge1; LIU Li2
1.Heilongjiang University of Traditional Chinese Medicine,Heilongjiang Harbin 150040,China;2.The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Heilongjiang Harbin 150040,China.
Keywords:
cervical cancer; precancerous lesion; heterogeneity; single-cell sequencing; tumor microenvironment
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2024.17.034
Abstract:
Cervical cancer is the common gynecological malignancy in the world,and it progresses pathologically over time.The traditional high-throughput sequencing technology only provides genetic information of multicellular populations at an average level,which cannot explain the heterogeneity of tumor microenvironment in cervical premalignant lesions and cervical cancer.The use of single-cell sequencing technology has enabled the biological properties of individual cells to be revealed,while providing a new means for the study of the tumor microenvironment at the single-cell level.In recent years,single-cell sequencing technology has advanced the understanding of cervical cancer significantly.In this paper,we review the study of single-cell sequencing on the characteristic changes of various types of cells in the tumor microenvironment of cervical cancer and its precancerous stage,and briefly look forward to the future development of prevention,diagnosis,and treatment of cervical cancer.

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Memo

Memo:
教育部“春晖计划”合作科研项目（编号：HLJ2019032）
Last Update: 2024-07-31