|Table of Contents|

Expression of SIAH2 in gastric adenocarcinoma tissues and its clinical significances

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 17
Page:
3260-3264
Research Field:
Publishing date:

Info

Title:
Expression of SIAH2 in gastric adenocarcinoma tissues and its clinical significances
Author(s):
MENG YuanXU BinXIE Fang
Department of Pathology,Fushun Central Hospital,Liaoning Fushun 113006,China.
Keywords:
gastric adenocarcinomaSIAH2clinicopathological factorsHER-2Hp
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2024.17.015
Abstract:
Objective:To investigate the expression levels of SIAH2 in gastric adenocarcinoma tissues and their relationships with clinicopathological factors of patients HER-2 expression,Hp infection in gastric adenocarcinoma tissues.Methods:The expression of SIAH2 and HER-2 protein was detected in 100 cases of gastric adenocarcinoma tissues by immunohistochemical Envision Hp infection was detected and by methylene blue.Results:Immunohistochemistry results showed different positive rate in gastric adenocarcinoma and adjacent normal tissues,with statistical significance.The positive rate of SIAH2 in gastric adenocarcinoma and normal gastric tissue was 68.0% and 10.0% respectively.The positive expression of SIAH2 in gastric adenocarcinoma was associated with tumor stage and lymph node metastasis(P<0.001).The positive SIAH2 expression was positively associated with positive HER-2 expression and Hp infection in gastric adenocarcinoma tissues.Conclusion:SIAH2 was abnormally expressed in gastric adenocarcinoma tissues,and associated with clinical stage,lymph node,Hp infection affecting in gastric cancer and HER-2 expression.The results indicated that SIAH2 may be associated with development of gastric adenocarcinoma and HER-2 expression,which is expected to be a new marker for early diagnosis and targetd therapy of gastric adenocarcinoma.

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Memo

Memo:
辽宁省科技厅项目(编号:2020JH2/10300078)
Last Update: 2024-07-31