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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 17

Page:

3248-3253

Research Field:

Publishing date:

Info

Title:

The correlation between the expression of TIMP-3 ＆ DNMT1 and prognosis of breast cancer patients

Author(s):

YU Jiao¹; LI Hanjie²; CHEN Xin²; WANG Qing¹; GE Peng²; LI Gang²

1.Department of Radiotherapy,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China;2.Department of Thoracic Surgery,the Second Affiliated Hospital of Xi'an Medical University,Shaanxi Xi'an 710038,China.

Keywords:

breast cancer; tissue inhibitor of matrix metalloproteinase 3; DNA methyltransferase 1; overall survival; disease free survival

PACS:

R737.9

DOI:

10.3969/j.issn.1672-4992.2024.17.013

Abstract:

Objective:To study the relationship between the expression of tissue inhibitor of matrix metalloproteinase 3(TIMP-3) and DNA methyltransferase 1(DNMT1) and clinical prognosis in breast cancer patients.Methods:58 surgical specimens of breast cancer with complete clinical data were collected,and the expressions of TIMP-3,DNMT1,ER,PR,HER-2,p53,Ki-67 in cancer tissues and corresponding adjacent tissues were detected by immunohistochemical SP method.The expression levels of TIMP-3 and DNMT1 were correlated with clinicopathological parameters and follow-up survival.All patients were followed up for more than 5 years.Results:We found that in breast cancer tissue,TIMP-3 was low expression,DNMT1 was high expression,and the expression of TIMP-3 and DNMT1 was negatively correlated.The expression level of TIMP-3 was negatively correlated with Ki-67,while the expression level of DNMT1 was positively correlated with Ki-67.There was no correlation with other clinical pathological parameters.Cox risk scale model analysis showed that only clinical stage and DNMT1 expression level were independent risk factors affecting overall survival(OS) and disease-free survival(DFS).The 5-year OS and DFS of TIMP-3 with low expression were significantly lower than those of the high expression group,while the 5-year OS and DFS of the DNMT1 high expression group were significantly lower than those of the low expression group.Conclusion:This study shows that the expression levels of TIMP-3 and DNMT1 in breast cancer are related to the malignant phenotype of tumor cells and the survival time of patients,which may become an important indicator to judge the prognosis of breast cancer and serve as a basis for the formulation of treatment plans.

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Memo

Memo:

陕西省重点研发计划（编号：2023-YBSF-329）；陕西省人民医院科技发展孵化基金（编号：2022YJY-01）；陕西省人民医院科技人才支持计划菁英人才项目（编号：2022JY-08）；西安医学院第二附属医院博士基金（编号：X2Y-R9）

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Last Update: 2024-07-31