|Table of Contents|

Research progress on the application of opioid free anesthesia in tumor surgery

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 16
Page:
3150-3155
Research Field:
Publishing date:

Info

Title:
Research progress on the application of opioid free anesthesia in tumor surgery
Author(s):
WANG Kai; ZHOU Wei; CHENG Chuanxi; CHEN Xiaobo
Department of Anesthesiology,the First College of Clinical Medical Science,China Three Gorges University (Yichang Central People's Hospital)，Hubei Yichang 443000,China.
Keywords:
opioid free anesthesia; tumor surgery; recurrence; transfer; prognosis; immunosuppression
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2024.16.033
Abstract:
Surgical surgery is the main treatment method for solid tumors,and perioperative anesthesia and pain management are closely related to postoperative rehabilitation,and may even affect tumor recurrence,metastasis,and long-term prognosis of patients.Compared with opioid anesthesia,opioid free anesthesia (OFA) can reduce the incidence of postoperative adverse reactions such as nausea and vomiting,improve the immune suppression caused by postoperative traumatic stress response,enhance the body's anti-tumor immune ability,and promote rapid postoperative recovery of patients.This article reviews the clinical application progress of OFA in tumor surgery,providing reference for perioperative anesthesia management.

References:

［1］DU KN,FENG L,NEWHOUSE A,et al.Effects of intraoperative opioid use on recurrence-free and overall survival in patients with esophageal adenocarcinoma and squamous cell carcinoma［J］.Anesthesia and Analgesia,2018,127(1):210-216.
［2］ZHANG Y,CHEN Q,CHEN X,et al.The effect of intraoperative fentanyl consumption on prognosis of colorectal liver metastasis treated by simultaneous resection:A propensity score matching analysis［J］.Journal of Cancer,2022,13(11):3189-3198.
［3］OH TK,JEON JH,LEE JM,et al.Investigation of opioid use and long-term oncologic outcomes for non-small cell lung cancer patients treated with surgery［J］.PLoS One,2017,12(7):671-680.
［4］MAHER DP,WONG W,WHITE PF,et al.Association of increased postoperative opioid administration with non-small-cell lung cancer recurrence:a retrospective analysis［J］.Br J Anaesth,2014,113(suppl_1):88-94.
［5］CATA JP,KEERTY V,KEERTY D,et al.A retrospective analysis of the effect of intraoperative opioid dose on cancer recurrence after non-small cell lung cancer resection［J］.Cancer Medicine,2014,3(4):900-908.
［6］OH TK,KIM K,JHEON SH,et al.Long-term oncologic outcomes,opioid use,and complications after esophageal cancer surgery［J］.Journal of Clinical Medicine,2018,7(2):331-339.
［7］EGAN TD.Are opioids indispensable for general anaesthesia［J］.Br J Anaesth,2019,122(6):127-135.
［8］SHIM H,GAN TJ.Side effect profiles of different opioids in the perioperative setting:are they different and can we reduce them［J］.Br J Anaesth,2019,123(3):266-268.
［9］CHRISTION B,CARLOS A,HONG L.The benefits of opioid free anesthesia and the precautions necessary when employing it［J］.Translational Perioperative and Pain Medicine,2020,7(1):152-157.
［10］FORGET P.Opioid-free anaesthesia.Why and how?A contextual analysis［J］.Anaesthesia,Critical Care & Pain Medicine,2019,38(2):169-172.
［11］BELOEIL H,LAVIOLLE B,MENARD C,et al.POFA trial study protocol:a multicentre,double-blind,randomised,controlled clinical trial comparing opioid-free versus opioid anaesthesia on postoperative opioid-related adverse events after major or intermediate non-cardiac surgery［J］.BMJ Open,2018,8(6):873-880.
［12］BRINCK EC,TIIPPANA E,HEESEN M,et al.Perioperative intravenous ketamine for acute postoperative pain in adults［J］.The Cochrane Database of Systematic Reviews,2018,12(12):465-477.
［13］TRIMMEL H,HHLBOK R,STAUDINGER T,et al.S(+)-ketamine:Current trends in emergency and intensive care medicine［J］.Wiener Klinische Wochenschrift,2018,130(9-10):356-366.
［14］WANG K,WU M,XU J,et al.Effects of dexmedetomidine on perioperative stress,inflammation,and immune function:systematic review and meta-analysis［J］.Br J Anaesth,2019,123(6):777-794.
［15］KUJAWA E,BLAU A,RAMETTA L.Anesthesia related to breast cancer recurrence and chronic pain:A review of current research［J］.AANA Journal,2021,89(4):291-298.
［16］D' AGOSTINO G,SSPORITO A,CECCHINATO V,et al.Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration［J］.Br J Anaesth,2018,121(4):962-968.
［17］DE OLIVEIRA GS,CASTRO-ALVES LJ,KHAN JH,et al.Perioperative systemic magnesium to minimize postoperative pain:a meta-analysis of randomized controlled trials［J］.Anesthesiology,2013,119(1):178-190.
［18］GHEZEL-AHNADI V,GHEZEL-AHMADI D,SCHIRREN J,et al.Perioperative systemic magnesium sulphate to minimize acute and chronic post-thoracotomy pain:a prospective observational study［J］.Journal of Thoracic Disease,2019,11(2):418-426.
［19］GRANT MC,SOMMER PM,HE C,et al.Preserved analgesia with reduction in opioids through the use of an acute pain protocol in enhanced recovery after surgery for open hepatectomy［J］.Regional Anesthesia and Pain Medicine,2017,42(4):451-457.
［20］MONISHA B,SUJATHA MP,SREERAMULU PN,et al.A comparative study of placebo versus opioid-free analgesic mixture for mastectomies performed under general anesthesia along with erector spinae plane block［J］.Cureus,2023,15(1):447-457.
［21］HONTOIR S,SAXENA S,GATTO P,et al.Opioid-free anesthesia:what about patient comfort?A prospective,randomized,controlled trial［J］.Acta Anaesthesiologica Belgica,2016,67(4):183-190.
［22］TRIPATHY S,RATH S,AGRAWAL S,et al.Opioid-free anesthesia for breast cancer surgery:An observational study［J］.Journal of Anaesthesiology,Clinical Pharmacology,2018,34(1):35-40.
［23］AN G,ZHANG Y,CHEN N,et al.Opioid-free anesthesia compared to opioid anesthesia for lung cancer patients undergoing video-assisted thoracoscopic surgery:A randomized controlled study［J］.PLoS One,2021,16(9):271-279.
［24］D'AMICO F,BARUCCO G,LICHERI M,et al.Opioid free anesthesia in thoracic surgery:A systematic review and meta analysis［J］.Journal of Clinical Medicine,2022,11(23):946-955.
［25］DEVINE G,CHENG M,MARTINEZ G,et al.Opioid-free anesthesia for lung cancer resection:A case-control study［J］.Journal of Cardiothoracic and Vascular Anesthesia,2020,34(11):3036-3040.
［26］AN G,WANG G,ZHAO B,et al.Opioid-free anesthesia compared to opioid anesthesia for laparoscopic radical colectomy with pain threshold index monitoring:a randomized controlled study［J］.BMC Anesthesiology,2022,22(1):241-253.
［27］ALIEV VA,BASHANKAEV BN,LORIA IZ,et al.Non-opioid multimodal anesthesia in the surgical treatment of colorectal cancer［J］.Khirurgiia,2019,8(2):54-59.
［28］TOLESKA M,DIMITROVSKI A,DIMITROVSKA NT.Comparation among opioid-based,low opioid and opioid free anesthesia in colorectal oncologic surgery［J］.Prilozi,2023,44(1):117-126.
［29］RANGEL FP,AULER JOC,CARMONA MJC,et al.Opioids and premature biochemical recurrence of prostate cancer:a randomised prospective clinical trial［J］.Br J Anaesth,2021,126(5):931-939.
［30］FAN X,WANG D,CHEN X,et al.Effects of anesthesia on postoperative recurrence and metastasis of malignant tumors［J］.Cancer Management and Research,2020,12(1):7619-7633.
［31］PAGE GG.Immunologic effects of opioids in the presence or absence of pain［J］.Journal of Pain and Symptom Management,2005,29(suppl_5):25-31.
［32］LIANG X,LIU R,CHEN C,et al.Opioid system modulates the immune function:A review［J］.Transl Perioper Pain Med,2016,1(1):5-13.
［33］BOLAND JW,POCKLEY AG.Influence of opioids on immune function in patients with cancer pain:from bench to bedside［J］.British Journal of Pharmacology,2018,175(14):2726-2736.
［34］GASPANI L,BIANCI M,LIMIROLI E,et al.The analgesic drug tramadol prevents the effect of surgery on natural killer cell activity and metastatic colonization in rats［J］.Journal of Neuroimmunology,2002,129(1-2):18-24.
［35］LENNON FE,MIRZAPOIAZOVA T,MAMBETSARIEV B,et al.The Mu opioid receptor promotes opioid and growth factor-induced proliferation,migration and epithelial mesenchymal transition (EMT) in human lung cancer［J］.PLoS One,2014,9(3):571-577.
［36］CONG X,HUANG Z,ZHANG L,et al.Effect of different anaesthesia methods on perioperative cellular immune function and long-term outcome in patients undergoing radical resection of esophageal cancer:a prospective cohort study［J］.American Journal of Translational Research,2021,13(10):11427-11438.
［37］YU L,CUI X,SONG P,et al.Perioperative pectoral nerve block type Ⅱ and postoperative recurrence in breast cancer:a randomized controlled trial［J］.BMC Surgery,2022,22(1):447-455.

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湖北省宜昌市医疗卫生科研项目（编号：A23-1-030）
Last Update: 1900-01-01