|Table of Contents|

Mitochondrial dicarboxylate carrier SLC25A10:New targets for the prevention and treatment of tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 16
Page:
3138-3144
Research Field:
Publishing date:

Info

Title:
Mitochondrial dicarboxylate carrier SLC25A10:New targets for the prevention and treatment of tumors
Author(s):
FANG YuZHOU YihanZHANG QingchunDING WeifengZHANG Jianfeng
School of Public Health,Nantong University,Jiangsu Nantong 226001,China.
Keywords:
SLC25A10glutathioneliver cancerhuman osteosarcomalung cancer
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2024.16.031
Abstract:
The dysregulation of cellular metabolism is crucial for sustaining the malignant proliferation of cancer cells.The solute carrier 25 (SLC25) nuclear-encoded transporter family within the mitochondrial inner membrane plays a profound role in cellular metabolism.SLC25A10 is highly expressed in various solid tumors,potentially serving as a novel target for cancer prevention and treatment.This article will summarize the relevant functions of mitochondrial SLC25A10 carriers and provide an overview of their progress in tumors,as well as their impact on cancer cell metabolism.

References:

[1] HE L,VASILIOU K,NEBERT DW.Analysis and update of the human solute carrier (SLC) gene superfamily[J].Hum Genomics,2009,3(2):195-206.
[2] HEDIGER MA,CLEMENCON B,BURRIER RE,et al.The ABCs of membrane transporters in health and disease(SLC series):introduction[J].Mol Aspects Med,2013,34(2-3):95-107.
[3] COLAS C,UNG PM,SCHLESSINGER A.SLC transporters:Structure,function,and drug discovery[J].MedChemComm,2016,7(6):1069-1081.
[4] POCHINI L,GALLUCCIO M.Heterologous (over) expression of human solute carrier (SLC) in yeast:A well-recognized tool for human transporter function/structure studies[J].Life (Basel),2022,12(8):1206.
[5] RIVES ML,JAVITCH JA,WICKENDEN AD.Potentiating SLC transporter activity:Emerging drug discovery opportunities[J].Biochem Pharmacol,2017,135:1-11.
[6] GYIMESI G,HEDIGER MA.Sequence features of mitochondrial transporter protein families[J].Biomolecules,2020,10(12):1611.
[7] ZORATTI M,BIASUTTO L,PARRASIA S,et al.Mitochondrial permeability transition pore:a snapshot of a therapeutic target[J].Expert Opin Ther Targets,2024,28(1-2):1-3.
[8] KUNJI ERS,KING MS,RUPRECHT JJ,et al.The slc25 carrier family:Important transport proteins in mitochondrial physiology and pathology[J].Physiology(Bethesda),2020,35(5):302-327.
[9] PALMIERI F.The mitochondrial transporter family SLC25:identification,properties and physiopathology[J].Mol Aspects Med,2013,34(2-3):465-484.
[10] ZIEGLER M,MONNE M,NIKIFOROV A,et al.Welcome to the family:Identification of the nad+transporter of animal mitochondria as member of the solute carrier family slc25[J].Biomolecules,2021,11(6):880.
[11] FIERMONTE G,PALMIERI L,DOLCE V,et al.The sequence,bacterial expression,and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and caenorhabditis elegans[J].J Biol Chem,1998,273(38):24754-24759.
[12] RUPRECHT JJ,KUNJI ERS.The slc25 mitochondrial carrier family:Structure and mechanism[J].Trends Biochem Sci,2020,45(3):244-258.
[13] LASH LH.Mitochondrial GSH transport and intestinal cell injury:a commentary on "Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis"[J].Free Radic Biol Med,2008,44(5):765-767.
[14] JANG S,CHAPA-DUBOCQ XR,TYURINA YY,et al.Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes[J].Redox Biol,2021,45:102021.
[15] GRIFFITH OW,MEISTER A.Origin and turnover of mitochondrial glutathione[J].Proc Natl Acad Sci U S A,1985,82(14):4668-4672.
[16] LASH LH.Mitochondrial glutathione transport:physiological,pathological and toxicological implications[J].Chem Biol Interact,2006,163(1-2):54-67.
[17] KWON DH,LEE H,PARK C,et al.Glutathione induced immune-stimulatory activity by promoting m1-like macrophages polarization via potential ros scavenging capacity[J].Antioxidants,2019;8(9):413.
[18] LIU RM,GASTON PRAVIA KA.Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis[J].Free Radic Biol Med,2010,48(1):1-15.
[19] TRAGNI V,PRIMIANO G,TUMMOLO A,et al.Personalized medicine in mitochondrial health and disease:Molecular basis of therapeutic approaches based on nutritional supplements and their analogs[J].Molecules,2022,27(11):3494.
[20] ZHOU X,PAREDES JA,KRISHNAN S,et al.The mitochondrial carrier SLC25A10 regulates cancer cell growth[J].Oncotarget,2015,6:(11)9271-9283.
[21] ZHAO Q,ZHOU X,CURBO S et al.Metformin downregulates the mitochondrial carrier SLC25A10 in a glucose dependent manner[J].Biochem Pharmacol,2018,156:444-450.
[22] NOORIAN S,MOHAMMADPOOR NAMI S,NOURI GHONBALANI Z,et al.Compound heterozygous mutations presented with quadriparesis and menopause.A case report[J].Twin Res Hum Genet,2022,25(2):74-76.
[23] NGUYEN TT,QUAN X,HWANG KH,et al.Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells[J].Am J Physiol Endocrinol Metab,2015,308(11):e933-941.
[24] HLOUSCHEK J,RITTER V,WIRSDORFER F,et al.Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia[J].Cancer Lett,2018,439:24-38.
[25] MONTERO J,MORALES A,LLACUNA L,et al.Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma[J].Cancer Res,2008,68(13):5246-5256.
[26] BAULIES A,MONTERO J,MATIAS N,et al.The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading[J].Redox Biol,2018,14:164-177.
[27] AN YA,CHEN S,DENG Y,et al.The mitochondrial dicarboxylate carrier prevents hepatic lipotoxicity by inhibiting white adipocyte lipolysis[J].J Hepatol,2021,75(2):387-399.
[28] ZHOU Y,YANG C,WANG K,et al.MicroRNA-33b inhibits the proliferation and migration of osteosarcoma cells via targeting hypoxia-inducible factor-1α[J].Oncol Res,2017,25(3):397-405.
[29] WARNATZ HJ,SCHMIDT D,MANKE T,et al.The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle[J].J Biol Chem,2011,286(26):23521-23532.
[30] WIEL C,LE GAL K,IBRAHIM MX,et al.BACH1 stabilization by antioxidants stimulates lung cancer metastasis[J].Cell,2019,178(2):330-345.e22.
[31] SELIM MS,KASSEM AB,EL-BASSIOUNY NA,et al.Polymorphic renal transporters and cisplatin' s toxicity in urinary bladder cancer patients:current perspectives and future directions[J].Med Oncol,2023,40(2):80.
[32] WANG B,CAO C,LIU X,et al.BRCA1-associated protein inhibits glioma cell proliferation and migration and glioma stem cell self-renewal via the TGF-β/PI3K/AKT/mTOR signalling pathway[J].Cell Oncol (Dordr),2020,43(2):223-235.
[33] MORTAZAVI M,MOOSAVI F,MARTINI M,et al.Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer[J].Crit Rev Oncol Hematol,2022,39(6):1-16.
[34] LIU X,ZHAO P,WANG X,et al.Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells[J].J Exp Clin Cancer Res,2019,38(1):184.
[35] LI W,HU S,TIAN C,et al.TRIP4 transcriptionally activates DDIT4 and subsequent mTOR signaling to promote glioma progression[J].Free Radic Biol Med,2021,177:31-47.
[36] GOUBERT E,MIRCHEVA Y,LASORSA FM,et al.Inhibition of the mitochondrial glutamate carrier SLC25A22 in astrocytes leads to intracellular glutamate accumulation[J].Front Cell Neurosci,2017,11:149.
[37] WIRSCHING HG,WELLER M.The role of molecular diagnostics in the management of patients with gliomas[J].Curr Treat Options Oncol,2016,17(10):51.
[38] MOTAMEDIAN E,GHAVAMI G,SARDARI S.Investigation on metabolism of cisplatin resistant ovarian cancer using a genome scale metabolic model and microarray data[J].Iran J Basic Med Sci,2015,18(3):267-276.
[39] EATON BR,SCHWARZ R,VATNER R,et al.Osteosarcoma[J].Pediatr Blood Cancer,2021,68(suppl_2):e28352.
[40] GILL J,GORLICK R.Advancing therapy for osteosarcoma[J].Nat Rev Clin Oncol,2021,18(10):609-624.
[41] CHEN C,XIE L,REN T,et al.Immunotherapy for osteosarcoma:Fundamental mechanism,rationale,and recent breakthroughs[J].Cancer Lett,2021,500:1-10.
[42] WANG G,XIA J,CHEN C,et al.SLC25A10 performs an oncogenic role in human osteosarcoma[J].Oncol Lett,2020,20(4):2.
[43] TANG Z,FANG Y,DU R.MicroRNA-107 induces cell cycle arrests by directly targeting cyclin E1 in ovarian cancer[J].Biochem Biophys Res Commun,2019,512:331-337.
[44] NEHA R,UMESH G,PROBHONJON B,et al.A pan-cancer metabolic atlas of the tumor microenvironment[J].Cell Reports,2022,39(6):1-16.

Memo

Memo:
National Natural Science Foundation of China(No.81974313);国家自然科学基金资助项目(编号:81974313); 江苏省南通市科技局基金资助项目(编号:JC22022040)
Last Update: 1900-01-01