|Table of Contents|

The mechanism of pyroptosis and its research progress in esophageal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 16
Page:
3117-3124
Research Field:
Publishing date:

Info

Title:
The mechanism of pyroptosis and its research progress in esophageal cancer
Author(s):
HAN Yuting1ZHANG Xiaoqing2WANG Fan1ZHAO Gelei1ZHANG Shan1LI Dongdong1LIU Peimin1
1.The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450002,China;2.The First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450042,China.
Keywords:
pyroptosismolecular mechanismesophageal cancerresearch advances
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2024.16.028
Abstract:
Pyroptosis is a programmed cell death mediated by caspases.Activation of caspases stimulates the cleavage of Gasdermin family proteins,releases inflammatory mediators and other cell contents,and induces a strong inflammatory response.Pyroptosis is present in a variety of diseases and participates in the regulation of cancer progression.Esophageal cancer is a common malignant tumor of digestive system.Due to its hidden symptoms,most of the clinically diagnosed cases are advanced,with poor prognosis,short survival time and poor quality of life.Existing studies have shown that triggering pyroptosis can relieve the phenomenon of drug resistance,and pyroptosis can be used as a target for new drug development and guide prognosis assessment.Therefore,this article reviews the molecular mechanism of pyroptosis and the research progress of pyroptosis in esophageal cancer,hoping to provide guidance for clinical medication.

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Memo

Memo:
National Natural Science Foundation of China(No.82204981);国家自然科学基金项目(编号:82204981);河南省中医药科学研究专项项目(编号:2021JDZX2002,2021ZY2115);河南省中医院博士科研基金项目(编号:2023BSJJ02)
Last Update: 1900-01-01