|Table of Contents|

Study on the relationship between three dimensional mammary gland tomography signs and molecular classification and histological grade

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 16
Page:
3093-3100
Research Field:
Publishing date:

Info

Title:
Study on the relationship between three dimensional mammary gland tomography signs and molecular classification and histological grade
Author(s):
LI Dongxue1; QIN Jinxia1; ZHUANG Shan1; XUN Mengya1; DING Chao2
1.Department of Radiology,Jiangsu Cancer Hospital,Jiangsu Nanjing 210000,China；2.Nanjing University of Chinese Medicine,Jiangsu Nanjing 210000,China.
Keywords:
breast cancer; digital breast 3D tomography; molecular typing; histological grade
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2024.16.024
Abstract:
Objective:To investigate the relationship between the signs of digital breast three dimensional tomography (DBT) and molecular classification and histological grade.Methods:118 female patients with breast cancer diagnosed and treated in our hospital from February 2020 to February 2023 were selected for DBT examination.The proportion of patients with DBT signs in different molecular types and histological grades of breast cancer was compared,and the diagnostic value of DBT signs in different molecular classification and histological grades of breastcancer was analyzed by receiver operating characteristic curve (ROC).Results:Among the 118 patients with breast cancer,12 were Luminal A,72 were Luminal B,15 were HER2 overexpression,and 19 were triple-negative.There was no statistical significance in the comparison between different pathological types of breast cancer molecular types as to whether the lesions were simple masses,whether the masses were accompanied by calcification,whether the edges were clear,lesion size,whether the structure was distorted,and whether there was unsymmetrical high-density shadow (P＞0.05).The difference was statistically significant in the comparison between different pathological types as to whether there were malignant calcification and burrs in breast cancer (P＜0.05).The proportion of simple mass in three negative types was higher than that in Luminal A,B and HER2 overexpression types (P＜0.05),while the other three types had no statistical significance (P＞0.05),and the proportion of structural distortion in three negative types was higher than that in Luminal A type (P＜0.05).The proportion of malignant calcification in HER2 overexpression type was higher than that in Luminal A,B and three negative types (P＜0.05),while the difference was not statistically significant between Luminal A,B and three negative types (P＞0.05),and the proportion of structural distortion in HER2 overexpression type was higher than that in Luminal A type (P＜0.05).Luminal A and B had a higher percentage of burrs than HER2 overexpression type and triple-negative type (P＜0.05),and there was no statistical significance between HER2 overexpression type and triple-negative type (P＞0.05).Among the 118 patients with breast cancer,13 cases were grade Ⅰ,70 cases were grade Ⅱ,and 35 cases were grade Ⅲ.The percentages of burr sign,lymph node positive and gland density ≥50% in grade Ⅲ were higher than those in grade Ⅰ and grade Ⅱ (P＜0.05).The AUC (95%CI) of DBT signs such as burr,malignant calcification and simple mass in diagnosis of Luminal A,B and HER2 overexpression type and triple-negative type were 0.742 (0.653~0.818),0.799 (0.715~0.867) and 0.815 (0.733~0.881),respectively (P＜0.05).The AUC (95%CI) of burr sign,lymph node and gland density in the diagnosis of grade Ⅲ breast cancer were 0.667 (0.575~0.751),0.802 (0.719~0.870) and 0.780 (0.694~0.851),respectively (P＜0.05).Conclusion:The molecular classification and histological grade of breast cancer are related to simple mass,malignant calcification,burr and burr sign,lymph node and gland density in DBT sign,respectively.DBT sign has high diagnostic value in molecular classification and histological grade of breast cancer.

References:

［1］HOUGHTON SC,HANKINSON SE.Cancer progress and priorities:Breast cancer［J］.Cancer Epidemiol Biomarkers Prev,2021,30(5):822-844.
［2］KATSURA C,OGUNMWONYI I,KANKAM HK,et al.Breast cancer:presentation,investigation and management［J］.Br J Hosp Med (Lond),2022,83(2):1-7.
［3］SARHANGI N,HAJJARI S,HEYDARI SF,et al.Breast cancer in the era of precision medicine［J］.Mol Biol Rep,2022,49(10):10023-10037.
［4］王雯琼,杨蔚,刘开惠,等.乳腺X线摄影、MRI及病理联合诊断乳腺癌分子分型［J］.中国医学影像技术,2023,39(2):210-215. WANG WQ,YANG W,LIU KH,et al.Molecular typing of breast cancer diagnosed by combined mammography,MRI and pathology［J］.Chinese Journal of Medical Imaging Technology,2019,39(2):210-215.
［5］CHONG A,WEINSTEIN SP,MCDONALD ES,et al.Digital breast tomosynthesis:Concepts and clinical practice［J］.Radiology,2019,292(1):1-14.
［6］KULKARNI S,FREITAS V,MURADALI D.Digital breast tomosynthesis:Potential benefits in routine clinical practice［J］.Can Assoc Radiol J,2022,73(1):107-120.
［7］中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2019年版)［J］.中国癌症杂志,2019,29(8):609-679. Breast Cancer Professional Committee of Chinese Anti-Cancer Association.Guidelines and norms for diagnosis and treatment of breast cancer of Chinese Anticancer Association (2019 Edition)［J］.Chinese Journal of Cancer,2019,29(8):609-679.
［8］American College of Radiology.Breast imaging reporting and data system,breast imaging atlas.Fifth ed［J］.American College of Radiology,2013:84-87.
［9］BENITEZ FUENTES JD,MORGAN E,DE LUNA AGUILAR A,et al.Global stage distribution of breast cancer at diagnosis:A systematic review and meta-analysis［J］.JAMA Oncol,2024,10(1):71-78.
［10］李鸿恩,吕培锋,谢汉民,等.乳腺导管原位癌、导管原位癌伴微浸润及浸润性导管癌的分子分型差异性［J］.现代肿瘤医学,2024,32(1):69-75. LI HE,LYU PF,XIE HM,et al.Differential molecular typing of ductal carcinoma in situ,ductal carcinoma in situ with microinvasion and invasive ductal carcinoma of breast［J］.Modern Oncology,2024,32(1):69-75.
［11］JIANG M,YANG J,LI K,et al.Insights into the theranostic value of precision medicine on advanced radiotherapy to breast cancer［J］.Int J Med Sci,2021,18(3):626-638.
［12］周源，许庆勇，尹惠子.乳腺癌分子分型与放射治疗相关性的研究进展［J］.现代肿瘤医学，2020,28(5):844-847. ZHOU Y,XU QY,YIN HZ.Progress of the relationship between molecular typing of breast cancer and radiotherapy［J］.Modern Oncology,2020,28(5):844-847.
［13］刘娜，马天江，支卫国.乳腺癌分子分型在新辅助化疗疗效及预后预测中的作用［J］.现代肿瘤医学，2017,25(10):1564-1568. LIU N,MA TJ,ZHI WG.Predictive role of breast cancer molecular subtype in response and outcome of breast cancer patients treated with neoadjuvant chemotherapy［J］.Modern Oncology,2017,25(10):1564-1568.
［14］COMSTOCK CE,GATSONIS C,NEWSTEAD GM,et al.Comparison of abbreviated breast MRI vs digital breast tomosynthesis for breast cancer detection among women with dense breasts undergoing screening［J］.JAMA,2020,323(8):746-756.
［15］SECHOPOULOS I,TEUWEN J,MANN R.Artificial intelligence for breast cancer detection in mammography and digital breast tomosynthesis:State of the art［J］.Semin Cancer Biol,2021,72:214-225.
［16］ 张曦,余莹莹,汪湍,等.三阴性乳腺癌的数字乳腺断层摄影和全数字化乳腺摄影征象及其诊断效能的分析［J］.实用放射学杂志,2022,38(8):1264-1267. ZHANG X,YU YY,WANG T,et al.Analysis of signs and diagnostic efficacy of digital mammography and digital mammography in triple-negative breast cancer［J］.Journal of Practical Radiology,2022,38(8):1264-1267.
［17］ 杨彩仙,赵宏光,刘慧,等.乳腺癌数字化X线三维断层摄影肿块边缘征象及其与病理学指标的相关性［J］.肿瘤研究与临床,2019,31(1):16-21. YANG CX,ZHAO HG,LIU H,et al.Correlation between tumor margin signs and pathological indicators in digital three-dimensional tomography of breast cancer［J］.Cancer Research and Clinic,2019,31(1):16-21.
［18］HORVAT JV,KEATING DM,RODRIGUES-DUARTE H,et al.Calcifications at digital breast tomosynthesis:Imaging features and biopsy techniques［J］.Radiographics,2019,39(2):307-318.
［19］LI J,ZHANG H,JIANG H,et al.Diagnostic performance of digital breast tomosynthesis for breast suspicious calcifications from various populations:A comparison with full-field digital mammography［J］.Comput Struct Biotechnol J,2018,17:82-89.
［20］WANG K,ZOU Z,SHEN H,et al.Calcification,posterior acoustic,and blood flow:Ultrasonic characteristics of triple-negative breast cancer［J］.J Healthc Eng,2022,2022:9336185.
［21］TIAN L,WANG L,QIN Y,et al.Systematic review and meta-analysis of the malignant ultrasound features of triple-negative breast cancer［J］.J Ultrasound Med,2020,39(10):2013-2025.
［22］MEMA E,SCHNABEL F,CHUN J,et al.The relationship of breast density in mammography and magnetic resonance imaging in women with triple negative breast cancer［J］.Eur J Radiol,2020,124:108813.
［23］ 姜伟,朱海涛,曹雄锋.乳腺癌分子分型特征与数字乳腺断层摄影征象相关性的研究进展［J］.江苏大学学报:医学版,2023,33(1):79-83. JIANG W,ZHU HT,CAO XF.Research progress on the correlation between molecular typing characteristics of breast cancer and digital mammography［J］.Journal of Jiangsu University:Medical Edition,2023,33(1):79-83.
［24］ 金全官,齐欣,王可人,等.非特殊型浸润性乳腺癌组织学分级与数字乳腺三维断层摄影征象之间的关系［J］.中国实验诊断学,2019,23(1):67-70. JIN QG,QI X,WANG KR,et al.The relationship between histological grade of non-specific invasive breast cancer and digital three-dimensional mammography［J］.Chinese Journal of Experimental Diagnostics,2019,23(1):67-70.
［25］BABKINA TM,DYKAN IM,GURANDO AV,et al.Detection of breast cancer presenting as a mass in women with dense breasts-digital breast tomosynthesis versus full-field digital mammography［J］.Exp Oncol,2020,42(3):215-219.

Memo

Memo:
江苏省高等学校自然科学研究面上项目(编号：19FJB360012）
Last Update: 1900-01-01