|Table of Contents|

Expression of CDX2 in duodenal carcinoma tissues and its relationship with prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 16
Page:
3024-3029
Research Field:
Publishing date:

Info

Title:
Expression of CDX2 in duodenal carcinoma tissues and its relationship with prognosis
Author(s):
PAN Jun; CHEN Yitian; CHU Xiaoyuan
Department of Medical Oncology,Cancer Center of PLA,Eastern Theater General Hospital of PLA,Jiangsu Nanjing 210002,China.
Keywords:
duodenal carcinoma; radical surgery; CDX2; prognosis
PACS:
R735.3
DOI:
10.3969/j.issn.1672-4992.2024.16.015
Abstract:
Objective:To investigate the expression of caudal homologous transcription factor 2(CDX2) in duodenal carcinoma and its relationship with prognosis.Methods:Clinical data and pathological sections of 31 patients with duodenal carcinoma after radical surgery confirmed by histopathology from September 2008 to December 2019 were collected.The expression of CDX2 was detected by immunohistochemistry.Kaplan-Meier method and Log-rank test were used for survival analysis.Cox proportional regression model was used for multivariate analysis.Results:The positive rate of CDX2 in duodenal carcinoma was 51.6%(16/31).The expression of CDX2 was related to TNM stage.The later the stage,the lower the CDX2 positive expression rate(P=0.016).Gender,age,differentiation,vascular thrombus,nerve invasion and pancreatic invasion were not correlated with CDX2 expression(P＞0.05).Univariate analysis showed that TNM stage,differentiation and CDX2 expression were correlated with the prognosis of duodenal carcinoma.The later TNM stage was,the lower the survival rate was(P=0.01).The survival rate of those with high differentiation was better than that of those with low differentiation(P=0.005).The survival rate of CDX2 positive patients was better than that of negative patients(P=0.002).Gender,age,vascular thrombus,nerve invasion and pancreatic invasion were not associated with prognosis(P＞0.05).Multivariate analysis showed that differentiation(RR=0.258,95%CI:0.072~0.934,P=0.039) and CDX2 expression(RR=0.265,95%CI:0.079~0.890,P=0.032) were independent prognostic factors of duodenal carcinoma.Conclusion:Differentiationand CDX2 expression are independent prognostic factors affecting duodenal carcinoma patients.The survival of patients with high differentiation is better than that of patients with low differentiation,and the survival of patients with positive CDX2 expression is better than that of patients with negative CDX2 expression.

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Memo

Memo:
CSCO-豪森肿瘤研究基金（编号：Y-HS2017-066）；吴阶平医学基金（编号：320.6750.2022-18-51）
Last Update: 1900-01-01