[1] SUNG H,FERLAY J,SIEGEL RL,et al.Global cancer statistics 2020:GLOBOCAN Eestimates of incidence and mortality worldwide for 36 cancers in 185 countries［J］.CA:A Cancer Journal for Clinicians,2021,71(3):209-249.
[2] XIA C,DONG X,LI H,et al.Cancer statistics in China and United States,2022:profiles,trends,and determinants［J］.Chinese Medical Journal,2022,135(5):584-590.
[3] LUCIEN N,SIDOUX-WALTER F,OLIVESB,et al.Characterization of the gene encoding the human Kidd blood group/urea transporter protein.Evidence for splice site mutations in Jknull individuals［J］.J Biol Chem,1998,273(21):1297-12980.
[4] SHAYAKUL C,HEDIGER MA.The SLC14 gene family of urea transporters［J］.Pflugers Arch,2004,447(5):603-609.
[5] HOU R,KONG X,YANG B,et al.SLC14A1:a novel target for human urothelial cancer［J］.Clin Transl Oncol,2017,19(12):1438-1446.
[6] WALPOLE C,FARRELL A,MCGRANE A,et al.Expression and localization of a UT-B urea transporter in the human bladder［J］.American Journal of Physiology-Renal Physiology,2014,307(9):F1088-F1094.
[7] SHAYAKUL C,CLEMENCON B,HEDIGER MA.The urea transporter family(SLC14):physiological,pathological and structural aspects［J］.Mol Aspects Med,2013,34(2-3):313-322.
[8] LEVIN E J,CAO Y,ENKAVI G,et al.Structure and permeation mechanism of a mammalian urea transporter［J］.Proc Natl Acad Sci USA,2012,109(28):11194-11199.
[9] SPECTOR DA,YANG Q,WADE JB.High urea and creatinine concentrations and urea transporter B in mammalian urinary tract tissues［J］.Am J Physiol Renal Physiol,2007,292(1):F467-474.
10] RAFNAR T,VERMEULEN SH,SULEM P,et al.European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene［J］.Human Molecular Genetics,2011,20(21):4268-42681.
11] STEWART G.The emerging physiological roles of the SLC14A family of urea transporters［J］.Br J Pharmacol,2011,164(7):1780-1792.
12] LI J,SUN Y,YAN R,et al.Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation［J］.Biochim Biophys Acta Mol Cell Res,2022,1869(5):119236.
13] GEYER RR,MUSA-AZIZ R,ENKAVI G,et al.Movement of NH3 through the human urea transporter B:a new gas channel［J］.American Journal of Physiology-Renal Physiology,2013,304(12):F1447-F1457.
14] ZHANG X,ZHANG Y.Bladder cancer and genetic mutations［J］.Cell Biochem Biophys,2015,73(1):65-69.
[15] GARCIA-CLOSAS M,YE Y,ROTHMAN N,et al.A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1,a urea transporter gene on chromosome 18q12.3［J］.Hum Mol Genet,2011,20(21):4282-4289.
[16] HOU R,ALEMOZAFFAR M,YANG B,et al.Identification of a novel UT-B urea transporter in human urothelial cancer［J］.Front Physiol,2017,8(8):245.
[17] GUO Z,NIU X,FU G,et al.SLC14A1(UT-B) gene rearrangement in urothelial carcinoma of the bladder:a case report［J］.Diagn Pathol,2020,15(1):94.
[18] CHAN TC,WU WJ,LI WM,et al.SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma［J］.Theranostics,2020,10(25):11775-11793.
[19] CARROLL B,MAETZEL D,MADDOCKS OD,et al.Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity［J］.Elife,2016,5(5):19.
[20] FAUBERT B,SOLMONSON A,DEBERARDINIS RJ.Metabolic reprogramming and cancer progression［J］.Science,2020,368(6487):5473.
[21] ARCUCCI A,RUOCCO MR,GRANATO G,et al.Cancer:An oxidative crosstalk between solid tumor cells and cancer associated fibroblasts［J］.BioMed Research International,2016,2016(2):1-7.
[22] FIORI ME,DI FRANCO S,VILLANOVA L,et al.Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance［J］.Molecular Cancer,2019,18(1):70-86.
[23] LI Z,SUN C,QIN Z.Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming［J］.Theranostics,2021,11(17):8322-8336.
[24] SAHAI E,ASTSATUROV I,CUKIERMAN E,et al.A framework for advancing our understanding of cancer-associated fibroblasts［J］.Nat Rev Cancer,2020,20(3):174-186.
[25] MA Z,LI X,MAO Y,et al.Interferon-dependent SLC14A1(+) cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer［J］.Cancer Cell,2022,40(12):1550-1565 e7.
[26] YE B,DING K,LI K,et al.Study on the role of SLC14A1 gene in biochemical recurrence of prostate cancer［J］.Sci Rep,2022,12(1):17064.
[27] VELLAICHAMY A,SREEKUMAR A,STRAHLER JR,et al.Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases［J］.PLoS One,2009,4(9):e7075.
[28] CHEN H,ZHANG S,WU Z.Fanconi anemia pathway defects in inherited and sporadic cancers［J］.Transl Pediatr,2014,3(4):300-304.
[29] GIORGI EE,LI Y,CABERTO CP,et al.No association between the mitochondrial genome and prostate cancer risk:The multiethnic cohort［J］.Cancer Epidemiol Biomarkers Prev,2016,25(6):1001-1003.
[30] LAWRENCE MG,OBINATA D,SANDHU S,et al.Patient-derived models of abiraterone and enzalutamide resistant prostate cancer reveal sensitivity to ribosome directed therapy［J］.Eur Urol,2018,74(5):562-272.
[31] VAARALA MH,HIRVIKOSKI P,KAUPPILA S,et al.Identification of androgen-regulated genes in human prostate［J］.Mol Med Rep,2012,6(3):466-472.
[32] HONG L,WANG Y,CHEN W,et al.MicroRNA-508 suppresses epithelial-mesenchymal transition,migration,and invasion of ovarian cancer cells through the MAPK1/ERK signaling pathway［J］.J Cell Biochem,2018,119(9):7431-7440.
[33] WANG W,HU W,WANG Y,et al.MicroRNA-508 is downregulated in clear cell renal cell carcinoma and targets ZEB1 to suppress cell proliferation and invasion［J］.Exp Ther Med,2019,17(5):3814-3822.
[34] GUPTA S,SILVEIRA DA,MOMBACH JCM.Modeling the role of microRNA-449a in the regulation of the G2/M cell cycle checkpoint in prostate LNCaP cells under ionizing radiation［J］.PLoS One,2018,13(7):e0200768.
[35] BINDAL P,JALIL SA,HOLLE LM,et al.Potential role of rituximab in metastatic castrate-resistant prostate cancer［J］.J Oncol Pharm Pract,2019,25(6):1509-1511.
[36] AMMIRANTE M,LUO JL,GRIVENNIKOV S,et al.B-cell-derived lymphotoxin promotes castration-resistant prostate cancer［J］.Nature,2010,464(7286):302-305.
[37] LIU L,SUN Y,ZHAO Y,et al.Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis［J］.Cancer Sci,2018,109(12):3762-3773.
[38] WAN Z,WANG Y,LI C,et al.SLC14A1 is a new biomarker in renal cancer［J］.Clinical and Translational Oncology,2023,25(8):2607-2623.
[39] HU X,LI J,FU M,et al.The JAK/STAT signaling pathway:from bench to clinic［J］.Signal Transduct Target Ther,2021,6(1):402.