|Table of Contents|

Progress of dermatopontin in tumor research

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 14
Page:
2637-2640
Research Field:
Publishing date:

Info

Title:
Progress of dermatopontin in tumor research
Author(s):
FANG Yi1GUO Xueyao1SHAO Hongjing1ZHENG Xiaoyun1LIU Ye1LI Yang2
1.Second Clinical Department,China Medical University,Liaoning Shenyang 110122,China;2.Department of Molecular Cell Biology,School of Life Sciences,China Medical University,Liaoning Shenyang 110122,China.
Keywords:
dermatopontintumortumor microenvironment
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2024.14.026
Abstract:
Tumor initiation and progression are strongly linked to the microenvironment of tumor cells.The extracellular matrix is the major component of the tumor microenvironment,and dermatopontin (DPT),a secretory protein consisting of 183 amino acid residues,account for a high proportion of noncollagenous proteins of the extracellular matrix.DPT can inhibit tumorigenesis by increasing the activity of transforming growth factor-beta,inhibit tumor metastasis by binding to integrins,and block the potential signaling pathway of vitamin receptor D.This article mainly reviews the studies related to DPT and tumor.It is helpful to understand the mechanism of DPT and explore the possible role of DPT in human tumorigenesis and development.

References:

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Memo

Memo:
辽宁省自然科学基金面上项目(编号:2022-MS-197);“中国医科大学大学生创新创业训练计划”资助项目(编号:X202310159066)
Last Update: 1900-01-01