|Table of Contents|

The expression of PDCD4 and miR-107 in penile cancer tissue and their relationship with patient prognosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 14
Page:
2620-2624
Research Field:
Publishing date:

Info

Title:
The expression of PDCD4 and miR-107 in penile cancer tissue and their relationship with patient prognosis
Author(s):
WANG Zhi1; 2; 3; HE Changhai2; DONG Biao1; QIU Xuede3; LI Baoan2; ZHAO Qi2; WANG Hong2; ZHU Haidong2; LIU Junfeng2; LIU Zhengdao2; LYU Mingzhu4; JI
1.Department of Male,the Second Affiliated Hospital of Kunming Medical University,Yunnan Kunming 650000,China;2.Department of Urology,Nanyang First People's Hospital Affiliated to Henan University，Henan Nanyang 473000,China;3.Department of Urology,the Second Affiliated Hospital of Kunming Medical University,Yunnan Kunming 650000,China;4.Nanyang Medical College,Henan Nanyang 473000,China.
Keywords:
programmed cell death factor 4; penile cancer; microRNA-107; prognosis
PACS:
R737.27
DOI:
10.3969/j.issn.1672-4992.2024.14.022
Abstract:
Objective:To explore the expression level of programmed cell death factor 4 (PDCD4) and microRNA-107 (miR-107) in penile cancer tissue and their relationship with patient prognosis.Methods:A research was made of 32 patients with penile cancer diagnosed in our hospital from January 2018 to June 2020,and 32 pairs of penile cancer tissue (study group) and normal penile tissue adjacent to cancer (control group) were taken during surgery.The expression levels of PDCD4 and miR-107 in the two groups were detected by real-time quantitative reverse transcription-PCR,and their relationship with clinicopathologic parameters and prognosis was analyzed.Kaplan-Meier survival curve analysis and Logistic regression analysis were used to analyze the factors affecting the prognosis of patients with penile cancer.Results:The expression of PDCD4 in the study group was significantly lower than that in the control group,and the expression of miR-107 was significantly higher than that in the control group (P＜0.05).The expression level of PDCD4 and miR-107 was correlated with lymph node metastasis,histological grade of penis cancer (P＜0.05).Kaplan-Meier method was used to analyze the survival rate.The survival rate of the low expression group of miR-107 was significantly higher than that of the high expression group of miR-107,and the survival rate of the low expression group of PDCD4 was lower than that of the high expression group of PDCD4(P＜0.05).Multivariate analysis showed that high TNM stage,lymph node metastasis,low expression of PDCD4 and high expression of miR-107 were independent risk factors affecting the prognosis of patients with penile cancer (all P＜0.05).Conclusion:The expression of miR-107 and PDCD4 in patients with penile cancer is abnormally high and low,which are expected to be used as important indicators to predict the prognosis of penile cancer.

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