|Table of Contents|

Analysis of prognostic factors in children with non-Hodgkin' s lymphoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 14
Page:
2591-2595
Research Field:
Publishing date:

Info

Title:
Analysis of prognostic factors in children with non-Hodgkin' s lymphoma
Author(s):
WANG Ye; ZHANG Linlin; CHI Zuofei; SUN Ruowen; JIANG Zehui; XU Gang
Department of Pediatrics Hematology，Shengjing Hospital of China Medical University，Liaoning Shenyang 110000，China.
Keywords:
NHL; LDH; D-dimer; inflammatory index; PNI
PACS:
R733
DOI:
10.3969/j.issn.1672-4992.2024.14.017
Abstract:
Objective:To investigate the prognostic factors of children with non-Hodgkin's lymphoma (NHL).Methods:One hundred and eight patients with newly-diagnosed childhood NHL in our hospital from January 2012 to December 2022 were selected,and the medical records were collected.The life-table method was used to calculate the 5-year overall survival (OS) and progression-free survival (PFS),and the Cox proportional hazards model was used to analyze the prognostic factors.Results:Among the 108 children with NHL,the male to female ratio was 2.72∶1,and the mean age was 7.82 years.All children received standardized chemotherapy.The outcome included 21 deaths and 24 relapses/progressions,with a 5-year cumulative OS of 79.0% and a cumulative PFS of 71.0%.Univariate analysis showed that central nervous system invasion,LDH,D-dimer,neutrophil-to-lymphocyte ratio (NLR),and prognostic nutritional index (PNI) affected the prognosis of the children,while multivariate analysis showed that LDH,D-dimer,and PNI were independent prognostic factors.Risk scores were calculated by LDH,D-dimer,and PNI,and the survival rate was significantly lower in the high hazard score group than in the low hazard score group.Conclusion:Current chemotherapy strategies show favorable outcomes in children's NHL,LDH,D-dimer,and PNI are independent prognostic factors in such patients,and risk scores calculated by LDH,D-dimer,and PNI can be used for prognostic evaluation of pediatric NHL.

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