|Table of Contents|

The expression of UBE2S in esophageal squamous cell carcinoma and its clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 14
Page:
2561-2565
Research Field:
Publishing date:

Info

Title:
The expression of UBE2S in esophageal squamous cell carcinoma and its clinical significance
Author(s):
LI Wan; LI Mengyan; LIU Xianwen; LYU Yuanyuan; MA Yuqing
Department of Pathology,the First Affiliated Hospital,Xinjiang Medical University,State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Xinjiang Urumqi 830011,China.
Keywords:
esophageal squamous cell carcinoma; precancerous tissues; ubiquitin-conjugating enzyme 2S; prognosis
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2024.14.011
Abstract:
Objective:To investigate the expression and clinical significance of UBE2S in esophageal squamous cell carcinoma (ESCC).Methods:The expression of UBE2S in ESCC and precancerous tissues were detected by Immunohistochemical SP,the correlations between its expression and clinicopathological features were analyzed.The effect of UBE2S expression on ESCC prognosis was investigated.Results:The expression of UBE2S in ESCC was significantly higher than that in adjacent tissues (P=0.035).The positive rates of high-grade intraepithelial neoplasia (HIN) (P＜0.001) and ESCC (P＜0.001) were higher than that in adjacent tissues.The positive rates of HIN (P=0.016) and ESCC (P=0.008) were higher than that in low-grade intraepithelial neoplasia (LIN).The expression of UBE2S in ESCC patients was related to race (P＜0.001),and it was positively correlated with the expressions of TP53 (r=0.288,P＜0.001) and Ki67 (r=0.210,P=0.002).The expression of UBE2S is an independent risk factor affecting progression-free survival (P=0.005) and overall survival (P=0.005) in patients with ESCC.Conclusion:The high expression of UBE2S may be an independent risk factor of poor prognosis in patients with ESCC.However,the prognosis of UBE2S and ESCC on GEPIA has no statistical significance,which needs further study.

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Memo

Memo:
省部共建中亚高发病成因与防治国家重点实验室开放课题基金(编号：SKL-HIDCA-2020-4);National Natural Science Foundation of China(No.81860422);国家自然科学基金（编号：81860422）;新疆维吾尔自治区自然科学基金（编号：2022D01D71）
Last Update: 1900-01-01