|Table of Contents|

Research progress on the role of KRAB-associated protein 1(KAP1) in the occurrence and development of malignant tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 09
Page:
1733-1740
Research Field:
Publishing date:

Info

Title:
Research progress on the role of KRAB-associated protein 1(KAP1) in the occurrence and development of malignant tumors
Author(s):
WANG Xinmeng1; 2; LIN Yaru1; 2; LI Jinsong1; 2; XIONG Wei1; 2; 3
1.School of Basic Medicine,Dali University,Yunnan Dali 671000,China;2.Key Laboratory of Clinical Biochemical Testingin Yunnan Universities,Yunnan Dali 671000,China;3.Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Yunnan Dali 671000,China.
Keywords:
KAP1; malignant tumor; invasion; metastasis
PACS:
R73
DOI:
10.3969/j.issn.1672-4992.2024.09.028
Abstract:
KRAB-associated protein 1(KAP1) is a transcription cofactor first isolated and cloned by affinity chromatography in 1996.It is named for its ability to bind to KRAB domain-containing zinc family proteins(ZFPs).KAP1 is a multifunctional protein,which is involved in histone modification and chromatin remodeling,regulating DNA methylation,gene regulation as a transcriptional co-regulator,and DNA damage response.In addition,it has a variety of post-translational modifications such as phosphorylation and acetylation.The expression level of KAP1 is closely related to the occurrence and development of a variety of human malignant tumors and affects the prognosis of tumors.Therefore,KAP1 is expected to become a new diagnostic marker or therapeutic target for malignant tumors.This review focuses on the structure and function of KAP1 and its relationship with the occurrence and development of human malignant tumors,and further discusses the application prospect of KAP1 in the research of malignant tumors,in order to provide reference for the clinical diagnosis and treatment of malignant tumors.

References:

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Memo

Memo:
National Natural Science Foundation of China（No.82160516,32160167）;国家自然科学基金(编号:82160516,32160167);云南省科技厅科技计划项目(编号:202201AT070004,202301AT070023，202001BB050008)
Last Update: 2024-03-29