|Table of Contents|

Progress in the antitumor mechanism of piperamide

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 03
Page:
583-588
Research Field:
Publishing date:

Info

Title:
Progress in the antitumor mechanism of piperamide
Author(s):
CHEN Jianhai12LI Huibin12
1.Weifang Medical University,Shandong Weifang 261000,China;2.Linyi People's Hospital,Shandong Linyi 276000,China.
Keywords:
piperlonguminePLROSanti-tumourmechanism
PACS:
R730.52
DOI:
10.3969/j.issn.1672-4992.2024.03.036
Abstract:
In recent years,as the toxic and side effects of some modern anti-tumor drugs have increasingly emerged,natural plant medicine is gradually well-known and valued,Such as yew,taxus cuspidata,camptotheca acuminata decne,catharanthus roseus and so on.Among them,piperlongumine extracted from longum,due to its unique pharmacological activity,can kill tumor cells in a broad spectrum,but has no obvious toxic effects on normal cells,which has gradually attracted the attention of many researchers.However,the specific anti-tumor mechanism of piperlongumine has not yet been clarified.By using "Piperlongumine (PL)","reactive oxygen species (ROS)","anti-tumour","JNK","miRNA" as the key word,query relevant literatures in Wanfang database,CNKI,PubMed and other databases in recent 10 years to review its anti-tumor mechanism,laying a foundation for clinical drug research and development and clinical application.

References:

[1]RANJAN A, RAMACHANDRAN S,GUPTA N,et al.Role of phytochemicals in cancer prevention [J].Int J Mol Sci,2019,20(20):4981.
[2]PEI S,MINHAJUDDIN M,CALLAHAN KP,et al.Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells [J].J Biol Chem,2013,288(47):33542-33558.
[3]TRIPATHI SK,BISWAL BK.PIPERLONGUMINE,a potent anticancer phytotherapeutic:Perspectives on contemporary status and future possibilities as an anticancer agent [J].Pharmacol Res,2020,156:104772.
[4]RAJ L,IDE T,GURKAR AU,et al.Retraction note:selective killing of cancer cells by a small molecule targeting the stress response to ROS [J].Nature,2011,475(7355):231-234.
[5]HAYESJD,DINKOVA-KOSTOVA AT,TEW KD.Oxidative stress in cancer [J].Cancer Cell,2020,38(2):167-197.
[6]SENA LA,CHANDEL NS.Physiological roles of mitochondrial reactive oxygen species [J].Mol Cell,2012,48(2):158-167.
[7]TRACHOOTHAM D,ALEXANDRE J,HUANG P.Targeting cancer cells by ROS-mediated mechanisms:a radical therapeutic approach[J].Nat Rev Drug Discov,2009,8(7):579-591.
[8]WONDRAKGT.Redox-directed cancer therapeutics: molecular mechanisms and opportunities [J].Antioxid Redox Signal,2009,11(12):3013-3069.
[9]ZOU P,XIA Y,JI J,et al.Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer [J].Cancer Lett,2016,375(1):114-126.
[10]ZHANG Q,CHEN W,LYU X,et al.Piperlongumine,a novel TrxR1 inhibitor, induces apoptosis in hepatocellular carcinoma cells by ROS-mediated ER stress[J].Front Pharmacol,2019,10:1180.
[11]JIN HO,LEE YH,PARK JA,et al.Piperlongumine induces cell death through ROS-mediated CHOP activation and potentiates TRAIL-induced cell death in breast cancer cells [J].J Cancer Res Clin Oncol,2014,140(12):2039-2046.
[12]ZHOU J, HUANG Z,NI X,et al.Piperlongumine induces apoptosis and G2/M phase arrest in human osteosarcoma cells by regulating ROS/PI3K/Akt pathway [J].Toxicol In Vitro,2020,65:104775.
[13]THONGSOM S,SUGINTA W,LEE KJ,et al.Piperlongumine induces G2/M phase arrest and apoptosis in cholangiocarcinoma cells through the ROS-JNK-ERK signaling pathway [J].Apoptosis,2017,22(11):1473-1484.
[14]ALLAMAN-PILLET N,SCHORDERET DF.Piperlongumine promotes death of retinoblastoma cancer cells [J].Oncotarget,2021,12(9):907-916.
[15]DUAN Z,SU ZH,FANG DW,et al.Research progress in the function of C/EBP homologous protein [J].Journal of Molecular Diagnostics and Therapy,2021,13(1):165-168.
[16]DAVIS RJ.Signal transduction by the JNK group of MAP kinases [J].Cell,2000,103(2):239-252.
[17]HIBI M, LIN A,SMEAL T,et al.Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain [J].Genes Dev,2007,(11):2135-2148.
[18]SHIM HY,PARK JH,PAIK HD,et al.Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade,mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation [J].Mol Cells,2007,24(1):95-104.
[19]LIU LJ,TANG SS.Research progress of ROS mediated JNK signaling pathway [J].Progress in Modern Biomedicine,2010,10(7):1378-1380.
[20]LIU QR,LIU JM,CHEN Y,et al.Piperlongumine inhibits migration of glioblastoma cells via activation of ROS-dependent p38 and JNK signaling pathways [J].Oxid Med Cell Longev,2014,2014:653732.
[21]XIONG XX,LIU JM,QIU XY,et al.Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways [J].Acta Pharmacol Sin,2015,36(3):362-374. [22]KUMAR S, AGNIHOTRI N. Piperlongumine targets NF-κB and its downstream signaling pathways to suppress tumor growth and metastatic potential in experimental colon cancer[J].Mol Cell Biochem,2021,476(4):1765-1781.
[23]BORKIEWICZL,KALAFUT J,DUDZIAK K,et al.Decoding LncRNAs [J].Cancers (Basel),2021,13(11):2643.
[24]WANG KC,CHANG HY.Molecular mechanisms of long noncoding RNAs [J].Mol Cell,2011,43(6):904-914.
[25]KARKI K,HEDRICK E,KASIAPPAN R,et al.Piperlongumine induces reactive oxygen species (ROS)-dependent downregulation of specificity protein transcription factors [J].Cancer Prev Res,2017,10(8):467-477.
[26]LU X, XU C,XU Z,et al.Piperlongumine inhibits the growth of non-small cell lung cancer cells via the miR-34b-3p/TGFBR1 pathway [J].BMC Complement Med Ther,2021,21(1):15.
[27]DELANEY LM,FARIAS N,GHASSEMI RAD J,et al.The natural alkaloid piperlongumine inhibits metastatic activity and epithelial-to-mesenchymal transition of triple-negative mammary carcinoma cells [J].Nutr Cancer,2021,73(11-12):2397-2410.
[28]HU Y, LUO X,ZHOU J,et al.Piperlongumine inhibits the progression of osteosarcoma by downregulating the SOCS3/JAK2/STAT3 pathway via miR-30d-5p [J].Life Sci,2021,277:119501.
[29]GUO S,XING D,LYU B.Research progress of apoptosis,programmed cell necrosis and cell scorch [J].Journal of Chinese Practical Diagnosis and Therapy,2021,35(3):321-324.
[30]SHI J,GAO W,SHAO F.Pyroptosis:gasdermin-mediated programmed necrotic cell death [J].Trends Biochem Sci,2017,42(4):245-254.
[31]LI Q,CHEN L,DONG Z,et al.Piperlongumine analogue L50377 induces pyroptosis via ROS mediated NF-κB suppression in non-small-cell lung cancer [J].Chem Biol Interact,2019,313:108820.
[32]HUA JS,WANG SJ,LIU HF.Piperlongumine induces pyroptosis of gastric cancer cells by activating p38/Caspase-3/GSMDME pathway [J].Jinagsu Medical Journal,2022,48(03):217-221.
[33]XU R,YANG J,QIAN Y,et al.Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF [J].Nanoscale Horiz,2021,6(4):348-356.
[34]CHEN X,KANG R,KROEMER G,et al.Broadening horizons:the role of ferroptosis in cancer [J].Nat Rev Clin Oncol,2021,18(5):280-296.
[35]SU Y,ZHAO B,ZHOU L,et al.Ferroptosis,a novel pharmacological mechanism of anti-cancer drugs [J].Cancer Lett,2020,483:127-136.
[36]YAMAGUCHI Y,KASUKABE T,KUMAKURA S.Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis [J].Int J Oncol,2018,52(3):1011-1022.
[37]YANG Y,SUN S,XU W,et al.Piperlongumine inhibits thioredoxin reductase 1 by targeting selenocysteine residues and sensitizes cancer cells to erastin [J].Antioxidants (Basel),2022,11(4):710.
[38]KOMATSU M,WAGURI S,CHIBA T,et al.Loss of autophagy in the central nervous system causes neurodegeneration in mice [J].Nature,2006,441(7095):880-884.
[39]XU Z,HAN X,OU D,et al.Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy [J].Appl Microbiol Biotechnol,2020,104(2):575-587.
[40]HERAS-SANDOVAL D,PREZ-ROJAS JM,HERN NDEZ-DAMIN J,et al.The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration [J].Cell Signal,2014,26(12):2694-2701.
[41]WANG H,WANG Y,GAO H,et al.Piperlongumine induces apoptosis and autophagy in leukemic cells through targeting the PI3K/Akt/mTOR and p38 signaling pathways [J].Oncol Lett,2018,15(2):1423-1428.
[42]KUMAR S,AGNIHOTRI N.Piperlongumine,a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer [J].Biomed Pharmacother,2019,109:1462-1477.
[43]WANG F,MAO Y,YOU Q,et al.Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway [J].Int J Immunopathol Pharmacol,2015,28(3):362-373.
[44]邹向阳,李连宏.细胞周期调控与肿瘤[J].国际遗传学杂志,2006,29(1):70-73. ZOU XY,LI LH.Cell cycle control and tumor [J].International Journal of Genetics Int J Genet Jun,2006,29(1):70-73.
[45]KONG EH,KIM YJ,CHO HJ,et al.Piplartine induces caspase mediated apoptosis in PC-3 human prostate cancer cells [J].Oncol Rep,2008,20:785-792.
[46]WANG H,JIANG H,CORBET C,et al.Piperlongumine increases sensitivity of colorectal cancer cells to radiation:involvement of ROS production via dual inhibition of glutathione and thioredoxin systems [J].Cancer Lett,2019,450:42-52.
[47]SONG X,GAO T,LEI Q,et al.Piperlongumine induces apoptosis in human melanoma cells via reactive oxygen species mediated mitochondria disruption[J].Nutr Cancer,2018,70(3):502-511.
[48]SHRIVASTAVA S,KULKARNI P,THUMMURI D,et al.Piperlongumine,an alkaloid causes inhibition of PI3K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells [J].Apoptosis,2014,19(7),1148-1164.
[49]DIEPENBRUCK M,CHRISTOFORI G.Epithelial-mesenchymal transition (EMT) and metastasis:yes,no,maybe [J].Curr Opin Cell Biol,2016,43:7-13.
[50]LAMOUILLE S,XU J,DERYNCK R.Molecular mechanisms of epithelial-mesenchymal transition[J].Nat Rev Mol Cell Biol,2014,15(3):178-196.
[51]CHILVERY S,BANSOD S,SAIFI MA,et al.Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways [J].Int Immunopharmacol,2020,88:106909.
[52]GARINET S,DIDELOT A,DENIZE T,et al.Clinical assessment of the miR-34,miR-200,ZEB1 and SNAIL EMT regulation hub underlines the differential prognostic value of EMT miRs to drive mesenchymal transition and prognosis in resected NSCLC [J].Br J Cancer,2021,125(11):1544-1551.
[53]TIAN Y,PAN Q,SHANG Y,et al.MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2):impact on the epithelial-mesenchymal transition in colon cancer cells [J].J Biol Chem,2014,289(52):36101-36115.
[54]LIU D,QIU XY,WU X,et al.Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization [J].Biochem Biophys Res Commun,2017,494(1-2):165-172.
[55]ZHANG J,LI X,HAN X,et al.Targeting the thioredoxin system for cancer therapy [J].Trends Pharmacol Sci,2017,38(9):794-808.
[56]YAO JX,YAO ZF,LI ZF,et al.Radio-sensitization by piper longumine of human breast adenoma MDA-MB-231 cells in vitro [J].Asian Pac J Cancer Prev,2014,15(7):3211-3217.
[57]KANG Q,YAN S.Piperlongumine reverses doxorubicin resistance through the PI3K/Akt signaling pathway in K562/A02 human leukemia cells [J].Exp Ther Med,2015,9(4):1345-1350.
[58]PISKA K,KOCZURKIEWICZ P,WNUK D,et al.Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition [J].Chem Biol Interact,2019,300:40-48.
[59]ROH JL,KIM EH,PARK JY,et al.Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer [J].Oncotarget,2014,5(19):9227-9238.
[60]TAN LJ,LIU YQ,YAN J,et al.Advances in synthesis,antitumor mechanism and structural modification of piperlongumine [J].China Pharmacy,2021,32(4):508-512.
[61]ZHU CP.The key problem of tumor treatment based on ros - discussion on ros and its dose effect[D].Hangzhou:Zhejiang University,2015.

Memo

Memo:
山东省自然科学基金面上项目(编号:ZR2021MH290)
Last Update: 2023-12-29