[1]YOUNG DUK YANG,HAWON CHO,JAE YEON KOO,et al.TMEM16A confers receptor-activated calcium-dependent chloride conductance [J].Nature,2008,455(7217):1210-1215.
[2]ANTONELLA CAPUTO,EMANUELA CACI,LORETTA FERRERA,et al.TMEM16A,a membrane protein associated with calcium-dependent chloride channel activity [J].Science,2008,322(5901):590-594.
[3]BJORN CHRISTIAN SCHROEDER,TONG CHENG,YUH NUNG JAN,et al.Expression cloning of TMEM16A as a calcium-activated chloride channel subunit [J].Cell,2008,134(6):1019-1029.
[4]ZENG XQ,PAN DY,WU H,et al.Transcriptional activation of ANO1 promotes gastric cancer progression [J].Biochem Biophys Res Commun,2019,512(1):131-136.
[5]ADRIAN BRITSCHGI,ANKE BILL,HEIKE BRINKHAUS,et al.Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling [J].Proc Natl Acad Sci USA,2013,110(11):1026-1034.
[6]YAN YF,DING XY,HAN CH,et al.Involvement of TMEM16A/ANO1 upregulation in the oncogenesis of colorectal cancer [J].Biochim Biophys Acta Mol Basis Dis,2022,1868(6):166370.
[7]LI YD,ZHANG JS,HONG SL,et al.ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human SCC-25 cells [J].Med Oral Patol Oral Cir Bucal,2014,19(4):313-319.
[8]HU C,ZHANG RG,JIANG DP.TMEM16A as a potential biomarker in the diagnosis and prognosis of lung cancer [J].Arch Iran Med,2019,22(1):32-38.
[9]CHRISTIAN RUIZ,JOANA RAQUEL MARTINS,FLORIAN RUDIN,et al.Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis [J].PLoS One,2012,7(8):e43265.
[10]LU GH,SHI WL,ZHENG HY.Inhibition of STAT6/Anoctamin-1 activation suppresses proliferation and invasion of gastric cancer cells [J].Cancer Biother Radiopharm,2018,33(1):3-7.
[11]WANG H,YAO F,LUO SY,et al.A mutual activation loop between the Ca2+-activated chloride channel TMEM16A and EGFR/STAT3 signaling promotes breast cancer tumorigenesis [J].Cancer Lett,2019,455:48-59.
[12]ARTEMIS FILIPPOU,HENNA PEHKONEN,PIIA-RIITTA KARHEMO,et al.ANO1 expression orchestrates p27kip1/MCL1-mediated signaling in head and neck squamous cell carcinoma [J].Cancers,2021,13(5):1170.
[13]ANKE BILL,ABRAHAM GUTIERREZ,SUCHETA KULKARNI,et al.ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer [J].Oncotarget,2015,6(11):9173-9188.
[14]SHOHEI YOSHIMOTO,MIHO MATSUDA,KENICHI KATO,et al.Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinomacells [J].Eur J Pharmacol,2021,895:173881.
[15]UMAMAHESWAR DUVVURI,DANIEL J SHIWARSKI,XIAO D,et al.TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression [J].Cancer Res,2012,72(13):3270-3281.
[16]LIU ZT,ZHANG SS,HOU F,et al.Inhibition of Ca2+-activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling [J].Int J Cancer,2019,144(9):2215-2226.
[17]ZHANG CT,LIU JX,HAN ZY,et al.Inhibition of TMEM16A suppresses growth and induces apoptosis in hepatocellular carcinoma [J].Int J Clin Oncol,2020,25(6):1145-1154.
[18]SONG Y,GAO J,GUAN LZ,et al.Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling [J].Cell Death Dis,2018,9(6):703.
[19]LIU J,LIU Y,REN YG,et al.Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor-κB signaling pathway [J].Mol Med Rep,2014,9(3):1068-1074.
[20]HEE-JIN KIM,JEONG-YUB KIM,CHAN-WOONG JUNG,et al.ANO1 regulates the maintenance of stemness in glioblastoma stem cells by stabilizing EGFRvIII [J].Park Oncogene,2021,40(8):1490-1502.
[21]NEAL R GODSE,NAYEL KHAN,ZACHARY A YOCHUM,et al.TMEM16A/ANO1 inhibits apoptosis via downregulation of bim expression [J].Clin Cancer Res,2017,23(23):7324-7332.
[22]ANTONIO CELENTANO,TAMI YAP,RITA PAOLINI,et al.Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells[J].J Oral Pathol Med,2021,50(3):323-332.
[23]JESSE ROLT,ZENG WZ,ELIZABETH L EVANS,et al.Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing[J].Elife,2021,10:e65415.
[24]YU JL,LIAO HY.Piezo-type mechanosensitive ion channel component 1 (Piezo1) in human cancer[J].Biomed Pharmacother,2021,140:111692.
[25]HAN Y,LIU C,ZHANG DF,et al.Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle[J].Int J Oncol,2019,55(3):629-644.
[26]WANG XF,CHENG G,MIAO Y,et al.Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis[J].J Cell Mol Med,2021,25(4):2238-2253.
[27]YU Y,WU XA,LIU SS,et al.Piezo1 regulates migration and invasion of breast cancer cells via modulating cell mechanobiological properties[J].Acta Biochim Biophys Sin (Shanghai),2021,53(1):10-18.
[28]CHEN X,SUN X,WANG Z,et al.Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion[J].Acta Biochim Biophys Sin (Shanghai),2018,50(5):440-446.
[29]WANG YH,ZHANG J,JIANG P,et al.ASIC1a promotes acidic microenvironment-induced HCC cells migration and invasion by inducing autophagy[J].Eur J Pharmacol,2021,907:174252.
[30]ZHU L,YIN JM,ZHENG FH,et al.ASIC1 inhibition impairs the proliferation and migration of pancreatic stellate cells induced by pancreatic cancer cells[J].Neoplasma,2021,68(1):174-179.
[31]MASAKO NAKANISHI,AYAKA KORECHIKA,HARUKA YAMAKAWA,et al.Acidic microenvironment induction of interleukin-8 expression and matrix metalloproteinase-2/-9 activation via acid-sensing ion channel 1 promotes breast cancer cell progression[J].Oncol Rep,2021,45(3):1284-1294.
[32]LIU TB,TOBIAS STAUBER.The volume-regulated anion channel LRRC88/VRAC is dispensable for cell proliferation and migration[J].Int J Mol Sci,2019,20(11):2663.
[33]EUGENIO GALLO,ABDELLALI KELIL,MICHAEL HAUGHEY,et al.Inhibition of cancer cell adhesion, migration and proliferation by a bispecific antibody that targets two distinct epitopes on αv integrins[J].J Mol Biol,2021,433(15):167090.
[34]HU C,ZHANG RG,JIANG DP.TMEM16A as a potential biomarker in the diagnosis and prognosis of lung cancer [J].Arch Iran Med,2019,22(1):32-38.
[35]SUI YJ,SUN MY,WU F,et al.Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells [J].PLoS One,2014,9(12):e115443.
[36]LIU F,CAO QH,LU DJ,et al.TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-β signaling [J].Oncotarget,2015,6(13):11585-11599.
[37]DAVID CROTTES,YU-HSIU T LIN,CHRISTIAN J PETERS,et al.TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis [J].Proc Natl Acad Sci USA,2019,116(26):13026-13035.
[38]YOHAN SEO,KUNHI RYU,JINHONG PARK,et al.Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells [J].PLoS One,2017,12(3):0174935.
[39]YOHAN SEO,SUNG BAEK JEONG,JOO HAN WOO,et al.Diethylstilbestrol,a novel ANO1 inhibitor, exerts an anticancer effect on non-small cell lung cancer via inhibition of ANO1[J].Int J Mol Sci,2021,22(13):7100.
[40]JIA LH,LIU W,GUAN LZ,et al.Inhibition of calcium-activated chloride channel ANO1/TMEM16A suppresses tumor growth and invasion in human lung cancer [J].PLoS One,2015,10(8):e0136584.
[41]WANG TY,WANG H,YANG F,et al.Honokiol inhibits proliferation of colorectal cancer cells by targeting anoctamin 1/TMEM16A Ca 2+ -activated Cl - channels [J].Br J Pharmacol,2021,178(20):4137-4154.
[42]ZHANG X,ZHANG GH,ZHAO ZJ,et al.Cepharanthine,a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy [J].Biochim Biophys Acta Mol Cell Res,2021,1868(12):119132.
[43]ZHANG GH,ZHU L,XUE YC,et al.Benzophenanthridine alkaloids suppress lung adenocarcinoma by blocking TMEM16A Ca 2+-activated Cl - channels [J].Pflugers Arch,2020,472(10):1457-1467.
[44]GUO S,CHEN YF,SHI S,et al.Arctigenin,a novel TMEM16A inhibitor for lung adenocarcinoma therapy [J].Pharmacol Res,2020,155:104721.
[45]GUO S,CHEN YF,PANG CL,et al.Matrine is a novel inhibitor of the TMEM16A chloride channel with antilung adenocarcinoma effects [J].J Cell Physiol,2019,234(6):8698-8708.
[46]WANG HC,WANG TY,ZHANG ZY,et al.Simvastatin inhibits oral squamous cell carcinoma by targeting TMEM16A Ca 2+-activated chloride channel [J].J Cancer Res Clin Oncol,2021,147(6):1699-1711.
[47]ZENG JW,CHEN BY,LYU XF,et al.Transmembrane member 16A participates in hydrogen peroxide-induced apoptosis by facilitating mitochondria-dependent pathway in vascular smooth muscle cells [J].Br J Pharmacol,2018,175(18):3669-3684.
[48]LIAN H,CHENG Y,WU XY.TMEM16A exacerbates renal injury by activating P38/JNK signaling pathway to promote podocyte apoptosis in diabetic nephropathy mice [J].Biochem Biophys Res Commun,2017,487(2):201-208.
[49]PATRICIA PEREZ-CORNEJO,AVANTI GOKHALE,CHARITY DURAN,et al.Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network [J].Proc Natl Acad Sci USA,2012,109(26):10376-10381.
[50]JIN X,SHIHAB SHAH,LIU YN,et al.Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor [J].Sci Signal,2013,6(290):73.