|Table of Contents|

The mechanism discussion for ANO1 mediating malignant biological behavior of tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 03
Page:
561-565
Research Field:
Publishing date:

Info

Title:
The mechanism discussion for ANO1 mediating malignant biological behavior of tumors
Author(s):
ZHENG Xiaotian1GAO Fengtong1SHI Quan1YE Honglian1BAI Lichuan2PAN Xiaoli1
1.Department of Neurological Function,Shengjing Hospital,China Medical University,Liaoning Shenyang 110000,China;2.Department of Ion Channel Pharmacology,School of Pharmacy,China Medical University,Liaoning Shenyang 110000,China.
Keywords:
ANO1proliferationmigrationinfiltrationsignaling pathways
PACS:
R730.1
DOI:
10.3969/j.issn.1672-4992.2024.03.032
Abstract:
ANO1,also known as TMEM16A,as one of the molecular identities of calcium-activated voltage-dependent chloride channels,is widely distributed in a variety of tissues and organs in the body,mediating bronchial gland secretion,nociception,intestinal slow wave formation and other physiological functions.At the same time,ANO1 is involved in the occurrence and development of various pathological processes,such as malignant tumors,inflammation.Several reports have confirmed that the high expression of ANO1 is induced by multifold signaling pathways in the pathogenesis of malignant tumor,and then the high expression of ANO1 enhances the malignant biological behavior of tumor cells by activating different downstream signaling pathways.In this review,we focused on the possible mechanism by which the high expression of ANO1 in malignant tumor enhancing the malignant biological behavior of tumor cells.

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Last Update: 2023-12-29