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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2024 03

Page:

548-552

Research Field:

Publishing date:

Info

Title:

Research progress of the relationship between senescence and tumor

Author(s):

WANG Xinmiao; LI Jie; CAO Luchang; MA Xinyi; NI Baoyi; ZHU Guanghui

Department of Oncology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China.

Keywords:

tumor progression; cell senescence; research progress

PACS:

R730

DOI:

10.3969/j.issn.1672-4992.2024.03.029

Abstract:

Senescence is a persistent and irreversible state of growth arrest,often accompanied by morphological and structural changes,functional decline,and secretion of senescence associated secretory phenotype.In recent years,more and more studies have confirmed that cell senescence is closely related to tumor progression.This review discussed the relationship between cellular senescence and tumor progression,as well as the related research progress on the treatment of tumor by regulating senescence.

References:

£Û1£ÝZHENG RS.Cancer incidence and mortality in China,2016£ÛJ£Ý.Journal of the National Cancer Center,2022,2(1):1-9.
£Û2£ÝSMYTH EC,VERHEIJ M,ALLUM W,et al.Gastric cancer:ESMO clinical practice guidelines for diagnosis,treatment and follow-up£ÛJ£Ý.Ann Oncol,2016,27(suppl 5):v38-v49.
£Û3£ÝWAN M,GRAY-GAILARD EF,ELISSEEFF JH.Cellular senescence in musculoskeletal homeostasis,diseases,and regeneration£ÛJ£Ý.Bone Research,2021,9(1):41.
£Û4£ÝSUN Y,CAMPISI J,HIGANO C,et al.Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through 16B£ÛJ£Ý.Nature Medicine,2012,18(9):1359-1368.
£Û5£ÝSUN Y,ZHU D,CHEN F,et al.SFRP2 augments Wnt16B signaling to promote therapeutic resistance in the damaged tumor microenvironment£ÛJ£Ý.Oncogene,2016,35(33):4321-4334.
£Û6£ÝZHANG B,FU D,XU Q,et al.The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1£ÛJ£Ý.Nature Communications,2018,9(1):1723.
£Û7£ÝMARTINEZ P,BLASCO MA.Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins£ÛJ£Ý.Nature Reviews Cancer,2011,11(3):161-176.
£Û8£ÝAGUADO J,D'ADDA D FF,WOLVETANG E.Telomere transcription in ageing£ÛJ£Ý.Ageing Research Reviews,2020,62:101115.
£Û9£ÝDESPRES J,RAMDANI Y,DI GIOVANNI M,et al.Replicative senescence of human dermal fibroblasts affects structural and functional aspects of the golgi apparatus£ÛJ£Ý.Experimental Dermatology,2019,28(8):922-932.
£Û10£ÝBLUETHMANN SM,MARIOTTO AB,ROWLAND JH.Anticipating the "silver tsunami":prevalence trajectories and comorbidity burden among older cancer survivors in the united states£ÛJ£Ý.Cancer Epidemiology Biomarkers and Prevention,2016,25(7):1029-1036.
£Û11£ÝYOUSEFZADEH M,HENPITA C,VYAS R,et al.DNA damage-how and why we age£ÛJ£Ý.Elife,2021,10:e62852.
£Û12£ÝMUNOZ-ESPIN D,SERRANO M.Cellular senescence:from physiology to pathology£ÛJ£Ý.Nature Reviews Molecular Cell Biology,2014,15(7):482-496.
£Û13£ÝWANG J,CLAUSON CL,ROBBINS PD,et al.The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner£ÛJ£Ý.Aging Cell,2012,11(4):714-716.
£Û14£ÝROBINSON AR,YOUSEFZADEH MJ,ROZGAJA TA,et al.Spontaneous DNA damage to the nuclear genome promotes senescence,redox imbalance and aging£ÛJ£Ý.Redox Biology,2018,17:259-273.
£Û15£ÝACOSTA JC,GIL J.Senescence:a new weapon for cancer therapy£ÛJ£Ý.Trends in Cell Biology,2012,22(4):211-219.
£Û16£ÝEWALD JA,DESOTELLE JA,WILDING G,et al.Therapy-induced senescence in cancer£ÛJ£Ý.Journal of the National Cancer Institute,2010,102(20):1536-1546.
£Û17£ÝLIU Y,SANOFF HK,CHO H,et al.Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging£ÛJ£Ý.Aging Cell,2009,8(4):439-448.
£Û18£ÝSANOFF HK,DEAL AM,KRISHNAMURTHY J,et al.Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer£ÛJ£Ý.Journal of the National Cancer Institute,2014,106(4):u57.
£Û19£ÝWANG L,LANKHORST L,BERNARDS R.Exploiting senescence for the treatment of cancer£ÛJ£Ý.Nat Rev Cancer,2022,22(6):340-355.
£Û20£ÝZHU H,BLAKE S,KUSUMA FK,et al.Oncogene-induced senescence:from biology to therapy£ÛJ£Ý.Mech Ageing Dev,2020,187:111229.
£Û21£ÝWANG Z,LIU Y,TAKAHASHI M,et al.N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence£ÛJ£Ý.Proceedings of the National Academy of Sciences of the United States of America,2013,110(1):312-317. £Û22£ÝRAABE EH,LIM KS,KIM JM,et al.BRAF activation induces transformation and then senescence in human neural stem cells:a pilocytic astrocytoma model£ÛJ£Ý.Clinical Cancer Research,2011,17(11):3590-3599.
£Û23£ÝTIAN Y,LI H,QIU T,et al.Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-kappaB activation£ÛJ£Ý.Aging Cell,2019,18(1):e12858.
£Û24£ÝLICHTENBERG D,PINCHUK I.Oxidative stress,the term and the concept£ÛJ£Ý.Biochemical and Biophysical Research Communications,2015,461(3):441-444.
£Û25£ÝHERNANDEZ-SEGURA A,DE JONG TV,MELOV S,et al.Unmasking transcriptional heterogeneity in senescent cells£ÛJ£Ý.Current Biology,2017,27(17):2652-2660.
£Û26£ÝBRANDL A,HARTMANN A,BECHMANN V,et al.Oxidative stress induces senescence in chondrocytes£ÛJ£Ý.Journal of Orthopaedic Research,2011,29(7):1114-1120.
£Û27£ÝWILEY CD,VELARDE MC,LECOT P,et al.Mitochondrial dysfunction induces senescence with a distinct secretory phenotype£ÛJ£Ý.Cell Metabolism,2016,23(2):303-314.
£Û28£ÝSINGH B,SCHOEB TR,BAJPAI P,et al.Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function£ÛJ£Ý.Cell Death & Disease,2018,9(7):735.
£Û29£ÝACOSTA JC,BANITO A,WUESTEFELD T,et al.A complex secretory program orchestrated by the inflammasome controls paracrine senescence£ÛJ£Ý.Nature Cell Biology,2013,15(8):978-990.
£Û30£ÝCOPPE JP,DESPREZ PY,KRTOLICA A,et al.The senescence-associated secretory phenotype:the dark side of tumor suppression£ÛJ£Ý.Annual Review of Pathology,2010,5:99-118.
£Û31£ÝHE S,SHARPLESS NE.Senescence in health and disease£ÛJ£Ý.Cell,2017,169(6):1000-1011.
£Û32£ÝKIRKLAND JL,TCHKONIA T.Cellular senescence: a translational perspective£ÛJ£Ý.EBioMedicine,2017,21:21-28.
£Û33£ÝTAKASUGI M,OKADA R,TAKAHASHI A,et al.Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2£ÛJ£Ý.Nature Communications,2017,8:15729.
£Û34£ÝELSAYED R,ELASHIRYM,LIU Y,et al.Porphyromonas gingivalis provokes exosome secretion and paracrine immune senescence in bystander dendritic cells£ÛJ£Ý.Front Cell Infect Microbiol,2021,11:669989.
£Û35£ÝHERNANDEZ-SEGURA A,DE JONG TV,MELOV S,et al.Unmasking transcriptional heterogeneity in senescent cells£ÛJ£Ý.Current Biology,2017,27(17):2652-2660.
£Û36£ÝBAI J,WANG Y,WANG J,et al.Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling£ÛJ£Ý.American Journal of Physiology - Cell Physiology,2020,318(5):C1005-C1017.
£Û37£ÝCAMPISI J.Aging,cellular senescence and cancer£ÛJ£Ý.Annu Rev Physiol,2013,75:685-705.
£Û38£ÝNACARELLI T,LAU L,FUKUMOTO T,et al.NAD(+) metabolism governs the proinflammatory senescence-associated secretome£ÛJ£Ý.Nature Cell Biology,2019,21(3):397-407.
£Û39£ÝYASUDA T,KOIWA M,YONEMURA A,et al. Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination£ÛJ£Ý.Cell Reports,2021,34(8):108779.
£Û40£ÝMALAQUIN N,VERCAMER C,BOUALI F,et al.Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis£ÛJ£Ý.PLoS One,2013,8(5):e63607.
£Û41£ÝKRIZHANOVSKY V,YON M,DICKINS RA,et al.Senescence of activated stellate cells limits liver fibrosis£ÛJ£Ý.Cell,2008,134(4):657-667.
£Û42£ÝMENG Y,EFIMOVA EV,HAMZEH KW,et al.Radiation-inducible immunotherapy for cancer:senescent tumor cells as a cancer vaccine£ÛJ£Ý.Mol Ther,2012,20(5):1046-1055.
£Û43£ÝVAN TUYN J,JABER-HIJAZI F,MACKENZIE D,et al.Oncogene-expressing senescent melanocytes up-regulate mhc class II, a candidate melanoma suppressor function£ÛJ£Ý.J Invest Dermatol,2017,137(10):2197-2207.
£Û44£ÝMARIN I,BOIX O,GARCIA-GARIJO A,et al.Cellular senescence is immunogenic and promotes anti-tumor immunity£ÛJ£Ý.Cancer Discovery,2022,13(2):410-431.
£Û45£ÝEGGERT T,WOLTER K,JI J,et al.Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression£ÛJ£Ý.Cancer Cell,2016,30(4):533-547.
£Û46£ÝPALMER S,ALBERGANTE L,BLACKBURN CC,et al.Thymic involution and rising disease incidence with age£ÛJ£Ý.Proc Natl Acad Sci USA,2018,115(8):1883-1888.
£Û47£ÝZ¦ZPHEL D,ANGENENDT A,KASCHEK L,et al.Faster cytotoxicity with age:increased perforin and granzyme levels in cytotoxic CD8+ T cells boost cancer cell elimination£ÛJ£Ý.Aging Cell,2022,21(8):e13668.
£Û48£ÝPEREZ-MANCERA PA,YOUNG AR,NARITA M.Inside and out:the activities of senescence in cancer£ÛJ£Ý.Nat Rev Cancer,2014,14(8):547-558.
£Û49£ÝSCHMITT CA,FRIDMAN JS,YANG M,et al.A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy£ÛJ£Ý.Cell,2002,109(3):335-346.
£Û50£ÝDORR JR,YU Y,MILANOVIC M,et al.Synthetic lethal metabolic targeting of cellular senescence in cancer therapy£ÛJ£Ý.Nature,2013,501(7467):421-425.
£Û51£ÝZON LI.Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal£ÛJ£Ý.Nature,2008,453(7193):306-313.
£Û52£ÝMILANOVIC M,FAN D,BELENKI D,et al.Senescence-associated reprogramming promotes cancer stemness£ÛJ£Ý.Nature,2018,553(7686):96-100.
£Û53£ÝZHU Y,TCHKONIA T,PIRTSKHALAVA T,et al.The Achilles' heel of senescent cells:from transcriptome to senolytic drugs£ÛJ£Ý.Aging Cell,2015,14(4):644-658.
£Û54£ÝWANG L,JIN H,JOCHEMS F,et al.cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis£ÛJ£Ý.Nature Cancer,2022,3(11):1284-1299.
£Û55£ÝJUNE CH,O'CONNOR RS,KAWALEKAR OU,et al.CAR T cell immunotherapy for human cancer£ÛJ£Ý.Science,2018,359(6382):1361-1365.
£Û56£ÝAMOR C,FEUCHT J,LEIBOLD J,et al.Senolytic CAR T cells reverse senescence-associated pathologies£ÛJ£Ý.Nature,2020,583(7814):127-132.
£Û57£ÝZHOU H,HUANG B,DU J,et al.Role of the JAK2/STAT pathway and losartan in human glomerular mesangial cell senescence£ÛJ£Ý.Molecular Medicine Reports,2010,3(3):393-398.
£Û58£ÝWU W,FU J,GU Y,et al.JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells£ÛJ£Ý.Journal of Endocrinology,2020,245(1):141-153.
£Û59£ÝHUBACKOVA S,NOVAKOVA Z,KREJCIKOVA K,et al.Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling£ÛJ£Ý.Cell Cycle,2010,9(15):3085-3099.
£Û60£ÝHERNANDEZ-SEGURA A,NEHME J,DEMARIA M.Hallmarks of cellular senescence£ÛJ£Ý.Trends in Cell Biology,2018,28(6):436-453.
£Û61£ÝFLEMMING A.Target identification:unravelling thalidomide teratogenicity£ÛJ£Ý.Nat Rev Drug Discov,2010,9(5):361.
£Û62£ÝMALIK S,COHEN PR.Thalidomide-then and now: case report of a woman with thalidomide embryopathy and review of current thalidomide uses£ÛJ£Ý.Cureus,2021,13(8):e17070.

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Memo:

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Last Update: 2023-12-29