|Table of Contents|

Advances in research on the pathogenesis of cancer-related thrombosis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 03
Page:
545-548
Research Field:
Publishing date:

Info

Title:
Advances in research on the pathogenesis of cancer-related thrombosis
Author(s):
DONG BihanZHANG Zhiren
Department of Cardiovascular Medicine,Affiliated Cancer Hospital of Harbin Medical University, Heilongjiang Cancer and Heart Disease Diagnosis and Treatment Center,Heilongjiang Harbin 150081,China.
Keywords:
cancerthrombosispathogenesis
PACS:
R730.2
DOI:
10.3969/j.issn.1672-4992.2024.03.028
Abstract:
Venous thromboembolism (VTE) becomes an important complication affecting the quality of life of cancer patients with the enlargement of the population and prolonging of survival time.Among the many complications,venous thromboembolism has become the second leading cause of cancer death.To explore the mechanism of cancer-associated thrombosis is of great significance for prevention and treatment.Due to the complex mechanism of the occurrence and development of cancer and its extensive connection with thrombosis,several aspects of thrombosis induced mechanisms,such as the activation of coagulation cascade system,inflammatory factors and tumor-related products, which are involved in cancer,have been widely recognized in recent years.This article reviews the recent studies on the mechanism of thrombosis and cancer.

References:

[1]MILLER KD,NOGUEIRA L,MARIOTTO AB,et al.Cancer treatment and survivorship statistics,2019[J].CA Cancer J Clin,2019,69(5):363-385.
[2]FARGE D,FRERE C,CONNORS JM,et al.2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer[J].Lancet Oncol,2019,20(10):e566-e581.
[3]马军,秦叔逵,吴一龙,等.肿瘤相关静脉血栓栓塞症预防与治疗指南(2019版)[J].中国肿瘤临床,2019,46(13):653-660. MA J,QIN SK,WU YL,et al.Guidelines for the prevention and treatment of tumor-associated venous thromboembolism(2019)[J].Chin J Clin Oncol,2019,46(13):653-660.
[4]LITT HK,PARKS AL,VELAZQUEZ AI.Blood clots,or thrombosis,in patients with cancer[J].JAMA Oncol,2023,9(6):876.
[5]CAMPELLO E,ILICH A,SIMIONI P,et al.The relationship between pancreatic cancer and hypercoagulability:a comprehensive review on epidemiological and biological issues[J].Br J Cancer,2019,121(5):359-371.
[6]PRADES J,ARNOLD D,BRUNNER T,et al.Bratislava Statement:consensus recommendations for improving pancreatic cancer care[J].ESMO Open,2020,5(6):e001051.
[7]VAN DEN BERG YW,OSANTO S,REITSMA PH,et al.The relationship between tissue factor and cancer progression:insights from bench and bedside[J].Blood,2012,119(4):924-932.
[8]KHORANA AA,AHRENDT SA,RYAN CK,et al.Tissue factor expression,angiogenesis,and thrombosis in pancreatic cancer[J].Clin Cancer Res,2007,13(10):2870-2875.
[9]SAWAI H,LIU J,REBER HA,et al.Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system[J].Mol Cancer Res,2006,4(3):159-167.
[10]FALANGA A,MARCHETTI M,RUSSO L.The mechanisms of cancer-associated thrombosis[J].Thromb Res,2015,135,S8-S11.
[11]FALANGA A,SCHIEPPATI F,RUSSO L.Pathophysiology mechanisms of thrombosis in cancer patients[J].Cancer Treat Res,2019,179:11-36.
[12]BUIJS JT,VERSTEEG HH.Genes and proteins associated with the risk for cancer-associated thrombosis[J].Thromb Res,2020,191:S43-S49.
[13]MUSE O,PATELL R,PETERS CG,et al.The unfolded protein response links ER stress to cancer-associated thrombosis[J].JCI Insight,2023,31,8(19):e170148.
[14]ADES S,KUMAR S,ALAM M,et al.Tumor oncogene (KRAS) status and risk of venous thrombosis in patients with metastatic colorectal cancer[J].J Thromb Haemost,2015,13(6):998-1003.
[15]ANSARI D,ANSARI D,ANDERSSON R,et al.Pancreatic cancer and thromboembolic disease,150 years after trousseau[J].Hepatobiliary Surg Nutr,2015,4(5):325-335.
[16]李廷廷,战翠萍,崔久嵬.癌症相关性血栓形成的病理机制进展[J].中国实验诊断学,2019,23(05):932-935. LI TT,ZHAN CP,CUI JW.Progress of pathologic mechanism of cancer - associated thrombosis[J].Chinese Journal of Laboratory Diagnosis,2019,23(05):932-935.
[17]ILICH A,BOKAREV I,KEY NS.Global assays of fibrinolysis[J].Int J Lab Hematol,2017,39(5):441-447.
[18]SNODERLY HT,BOONE BA,BENNEWITZ MF.Neutrophil extracellular traps in breast cancer and beyond: current perspectives on NET stimuli,thrombosis and metastasis,and clinical utility for diagnosis and treatment[J].Breast Cancer Res,2019,21(1):145.
[19]LIU Z, WANG J, LIAO F,et al.Tumor-educated platelets facilitate thrombus formation through migration[J].Front Oncol,2022,24,12:857865.
[20]CARESTIA A,KAUFMAN T,RIVADENEYRA L,et al.Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets[J].J Leukoc Biol,2016,99(1):153-162.
[21]NADIR Y,BRENNER B.Heparanase procoagulant activity in cancer progression[J].Thromb Res,2016,140:S44-S48. [22]AXELMAN E,HENIG I,CRISPEL Y,et al.Novel peptides that inhibit heparanase activation of the coagulation system[J].Thromb Haemost,2014,112(3):466-477.
[23]ZHOU Y,TAO W,SHEN F,et al.The emerging role of neutrophil extracellular traps in arterial, venous and cancer-associated thrombosis[J].Front Cardiovasc Med,2021,8:786387.
[24]ABDOL RN,ELASKALANI O,METHAROM P.Pancreatic cancer-induced neutrophil extracellular traps: a potential contributor to cancer-associated thrombosis[J].Int J Mol Sci,2017,18(3):487.
[25]CEDERVALL J,OLSSON AK.Immunity gone astray - nets in cancer[J].Trends Cancer,2016,2(11):633-634.
[26]FOLCO EJ,MAWSON TL,VROMMAN A,et al.Neutrophil extracellular traps induce endothelial cell activation and tissue factor production through interleukin-1alpha and cathepsin g[J].Arterioscler Thromb Vasc Biol,2018,38(8):1901-1912.
[27]THALIN C,HISADA Y,LUNDSTROM S,et al.Neutrophil extracellular traps:villains and targets in arterial,venous,and cancer-associated thrombosis[J].Arterioscler Thromb Vasc Biol,2019,39(9):1724-1738.
[28]THALIN C,DEMERS M,BLOMGREN B,et al.NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation[J].Thromb Res,2016,139:56-64.
[29]TREJO-BECERRIL C,PEREZ-CARDENAS E,GUTIERREZ-DIAZ B,et al.Antitumor effects of systemic dnase i and proteases in an in vivo model[J].Integr Cancer Ther,2016,15(4):35-43.
[30]LEAL AC,MIZURINI DM,GOMES T,et al.Tumor-derived exosomes induce the formation of neutrophil extracellular traps: implications for the establishment of cancer-associated thrombosis[J].Sci Rep,2017,7(1):6438.
[31]BURNOUF T,CHOU ML,GOUBRAN H,et al.An overview of the role of microparticles/microvesicles in blood components: are they clinically beneficial or harmful[J].Transfus Apher Sci,2015,53(2):137-145.
[32]VAN NIEL G,D'ANGELO G,RAPOSO G.Shedding light on the cell biology of extracellular vesicles[J].Nat Rev Mol Cell Biol,2018,19(4):213-228.
[33]DATE K,ETTELAIE C,MARAVEYAS A.Tissue factor-bearing microparticles and inflammation:a potential mechanism for the development of venous thromboembolism in cancer[J].J Thromb Haemost,2017,15(12):2289-2299.
[34]LACROIX R,VALLIER L,BONIFAY A,et al.Microvesicles and cancer associated thrombosis[J].Semin Thromb Hemost,2019,45(6):593-603.
[35]YAMANAKA Y,SAWAI Y,NOMURA S.Platelet-derived microparticles are an important biomarker in patients with cancer-associated thrombosis[J].Int J Gen Med,2019,12:491-497.

Memo

Memo:
-
Last Update: 2023-12-29