|Table of Contents|

A value analysis of preoperative neutrophil-to-lymphocyte ratio in predicting the prognosis of patients with high-grade glioma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 03
Page:
451-455
Research Field:
Publishing date:

Info

Title:
A value analysis of preoperative neutrophil-to-lymphocyte ratio in predicting the prognosis of patients with high-grade glioma
Author(s):
HONG Hui1; 2; LI Huixian2; 3; ZHANG Yuening2; 4; LIU Qian2; 4; LIU Xiaozhen2; ZHANG Jinling2
1.Jinzhou Medical Univercity，Liaoning Jinzhou 121000，China；2.Department of Oncology，Linyi People's Hospital，Shandong Linyi 276000，China；3.Binzhou Medical Univercity，Shandong Yantai 264000，China；4.Weifang Medical University，Shandong Weifang 261000,China.
Keywords:
neutrophil-to-lymphocyte ratio; glioma; stratified prognosis
PACS:
R739.41
DOI:
10.3969/j.issn.1672-4992.2024.03.010
Abstract:
Objective:To investigate the predictive value of pre-operative neutrophil-lymphocyte ratio（NLR） on the clinical prognosis of glioma patients.Methods：The clinical data of 247 patients with postoperatively pathologically confirmed glioma in Linyi People's Hospital from February 2011 to November 2016 were retrospectively analyzed.Cox regression modelwas used to analyze the clinicopathological factors affecting patients' prognosis,and to clarify the independent risk factors affecting the prognosis.For independent risk factors,X-tile software based on the minimum P-value method was used to determine the optimal cutoff value for their prognostic risk stratification.Results：Multifactorial analysis showed that NLR（P=0.048，HR=1.12）,age（P=0.001，HR=1.04）,pathological diagnosis（P=0.001，HR=2.23） and IDH1（P=0.040，HR=0.37） were independent influencing factors affecting overall survival of patients with glioma.The group of glioma patients with preoperative NLR less than 2.21 had the best prognosis,the group of glioma patients with NLR greater than 3.15 had the worst prognosis,and the group of glioma patients with NLR greater than or equal to 2.21 and less than or equal to 3.15 had an intermediate prognosis.The Kaplan-Meier survival analysis showed that the OS time in the high NLR group was significantly shorter than that in the low NLR group.In the high,medium,and low NLR groups,the 5-year survival rates were 36%,50%,and 60%,respectively(P＜0.05).In a subgroup analysis of different tumor grades,the results of Cox multifactorial analysis showed that preoperative NLR(P=0.005,HR=1.29),age(P=0.026,HR=1.03),IDH1(P=0.03,HR=0.26),and Ki-67(P＜0.01,HR=5.53) were independent prognostic factors affecting high-grade glioma.In the low-grade glioma subgroup,preoperative NLR(P=0.028,HR=1.23) was significantly associated with prognosis.Kaplan-Meier survival curves showed that in high-grade glioma,the 5-year survival rate of patients in the low-to-high NLR group gradually decreased(P=0.000 4),and in low-grade glioma,the 5-year OS rate of NLR was not statistically significant(P=0.518).Conclusion：NLR is an independent prognostic factor for survival of patients with glioma,and the clinical prognosis of patients with high-grade glioma can be classified into high,intermediate,and low risk groups based on NLR values.

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山东省自然科学基金面上项目（编号：ZR2020MH292）
Last Update: 2023-12-29