|Table of Contents|

Clinical and pathological analysis of primary optic nerve tumor（17 cases）

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2024 02
Page:
261-266
Research Field:
Publishing date:

Info

Title:
Clinical and pathological analysis of primary optic nerve tumor（17 cases）
Author(s):
YANG Yali1; ZHANG Qi1; ZHAO Nishan1; YANG Yanli1; ZHOU Hong1; 2; YUE Lirong3
1.Department of Pathology;2.Department of Teaching Affairs;3.Department of Radiography,Affiliated Hospital of Yunnan University（The Second People's Hospital of Yunnan Province，Yunnan Eye Hospital）,Yunnan Kunming 650021,China.
Keywords:
primary optic nerve tumor; histopathological features; optic nerve glioma; Verhoeff cassification; optic nerve meningioma
PACS:
R739.4
DOI:
10.3969/j.issn.1672-4992.2024.02.010
Abstract:
Objective:To describe the clinical and histopathological features,pathological diagnosis anddiferential diagnosis of primary optic nerve tumor．Methods:The cases of primary optic nerve tumor in our hospital between the year 2005 to 2022 were collected to analyze the clinical,histopathological and immunohistochemical characteristics retrospectively,and a literature review were carried out in this report.Results:17 cases of primary optic nerve tumor were classified.It is found that 4 cases were optic nerve glioma(ONG) and 13 cases were optic nerve meningioma(OPM).Both ONG and OPM attacked female dominantly.All cases were unilateral and not a single bilateral case was appeared.The median patient age at diagnosis was 18 years in ONG while 42.4 years in OPM.Proptosis and vision loss were most common presentation for ONG and OPM.However,visual effects were particularly prominent in ONG.Histologically,ONG were classified into coarsely reticulated,coarsely fibrillated,and finely reticulated pattern according to their characteristics respectively by Verhoeff.The histological characteristics of OPM were similar to those of intracranial primary meningiomas,except that optic nerve were surrounded and compressed by tumors in the former.Conclusion:Among these primary optic nerve tumors,OPM is the most common histopathological type,ONG accounted for less common subtype,other tumors type of optic nerve were seldom seen.Histological features of OGN were summarized finely by Verhoeff,while meningiomas of optic nerve were similar as that of intracranial and intraspinal histologically except they surround and compress the optic nerve.Pathological diagnosis should be combined with clinical evidence,imaging examination and immunohistochemistry to identified with mimic lesions.

References:

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Memo

Memo:
云南省科技厅-昆明医科大学应用基础研究联合专项（编号：202001AY070001-086）；云南省心血管超声创新团队（编号：202305AS350021）
Last Update: 1900-01-01